How can we improve the diagnosis of heart failure?

Thomson, Clare; Cuthbert, Joe; O’Nwere-Tan, Teresa Adaora

doi:10.1177/17557380221128969

Cited by 2 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 Given this scenario, early diagnosis is deemed crucial because it can enhance both the quality of life and longevity of patients. 7 Studies have utilized noninvasive imaging to assess structural and functional alterations of the left ventricle (LV) and left atrium (LA) early to identify individuals at high risk of HF. Parameters such as the LV ejection fraction (LV EF), LV mass index (LVMI), global longitudinal strain of the LV (LV GLS), or LA volume index (LAVI) and LA strain have shown diagnostic value in HF, particularly in heart failure preserved ejection fraction (HFpEF).…”

Section: Introductionmentioning

confidence: 99%

Left Atrioventricular Coupling Index in Heart Failure Patients Using Echocardiography: A Simple Yet Effective Metric

Nguyen Ngoc Dang,

Viet Luong,

Khanh Tran

et al. 2024

Preprint

View full text Add to dashboard Cite

BackgroundHeart failure (HF) is a global health challenge, with significant rates of hospitalization and mortality. Timely diagnosis is crucial for patient outcomes. Noninvasive imaging techniques assess early changes in HF but typically focus on specific aspects of the left atrium (LA) or left ventricle (LV). However, the close physiological interplay between the LA and LV suggests that indices evaluating both chambers, like the left atrioventricular coupling index (LACI), may offer superior diagnosis value for HF.MethodThe cross-sectional study randomly selected 1145 people at a hospital in Vietnam. Following the exclusion criteria, 160 subjects were eligible for analysis and divided into patient and healthy control groups. The patient group consisted of 60 adults meeting the criteria for HF diagnosis according to the 2022 AHA/ACC/HFSA Guideline.ResultsLACI levels were significantly higher in the HF group compared to the control group. Notably, LACI levels were higher in the HF with preserved ejection fraction (HFpEF) group than in the HF with reduced ejection fraction (HFrEF) group. The LACI showed a diagnostic value for HFpEF, with the highest AUC of 0.95 (95% CI: 0.921 - 0.981, p<0.001) compared to LASr, LAScd, and LAVI, with an optimal threshold of 33.07 (sensitivity: 97.1%, specificity: 87.3%). In multivariate analysis, LACI was an independent factor of HFpEF when compared to standard indices for diagnosing HFpEF (OR = 1.144, 95% CI: 1.087–1.205, p<0.001).ConclusionHF patients display increased LACI variability compared to healthy individuals, with the most significant increase observed in the HFpEF group. The LACI is an easily assessable parameter with potential value in diagnosing HFpEF.What is already known on this topicPrevious studies assessing the Left Atrioventricular Coupling Index (LACI) using cardiac magnetic resonance imaging have demonstrated its predictive role in cardiovascular risk. However, clinical practice shows that echocardiography can also calculate the LACI. Echocardiography is widely available and can be performed repeatedly. Despite its promising utility, no studies to date have utilized echocardiography-measured LACI for diagnosing heart failure with preserved ejection fraction (HFpEF).What this study addsPatients with heart failure exhibit significantly higher LACI compared to the control group. Among heart failure patients, HFpEF have the highest LACI values. Additionally, LACI demonstrates superior diagnostic value for HFpEF compared to current echocardiographic parameters recommended in clinical practice.How this study might affect research, practice or policyThis study holds promising potential by contributing to the development of a straightforward echocardiographic index that can diagnose HFpEF compared to current measures. Further research on LACI across diverse global populations could provide more compelling evidence of its efficacy. This could potentially lead to recommendations for integrating this index into clinical practice guidelines for guiding the clinical diagnosis of HFpEF.Graphical AbstractGraphical Abstract: Left Atrioventricular Coupling Index in Heart Failure Patients Using Echocardiography: A Simple Yet Effective Metric. HFpEF, heart failure with preserved ejection fraction; LACI, left atrioventricular coupling index; LAVI, left atrial volume index, LASr, left atrial reservoir strain, LV GLS, left ventricular global longitudinal strain; LV EF, left ventricular ejection fraction; LAEDV, left atrial end-diastolic volume; LVEDV, left ventricular end-diastolic volume.

show abstract

Section: Introductionmentioning

confidence: 99%

Left Atrioventricular Coupling Index in Heart Failure Patients Using Echocardiography: A Simple Yet Effective Metric

Nguyen Ngoc Dang,

Viet Luong,

Khanh Tran

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Specificities of Treatment of Patients With Cardiovascular Risk in Comorbidity

Ovcharenko¹,

Tsyganenko²,

Rustamian³

et al. 2023

Act. Probl. of the Modern Med.

View full text Add to dashboard Cite

Recently, much attention has been paid to the concept introduced to the scientific community by the prominent American epidemiologist Alvan R. Feinstein - "comorbidity" (Latin co - together, morbus - disease). In his understanding, comorbidity demonstrates the combination of two and/or more chronic diseases in one patient, which are interconnected by pathophysiological mechanisms, and simultaneously manifest themselves in one patient, regardless of the degree of activity of each of them. At the same time, comorbidity leads to the formation of new mechanisms of disease development, the unfolding of an additional clinical picture and the addition of complications and courses that are not characteristic of the underlying disease, with a significant negative impact on the quality and duration of life of patiens. Among all patients with comorbidities, patients with cardiovascular risk have been and remain one of the most difficult among all categories of patients. One or other comorbidity can prognostic allylead to a deterioration in the patient's functional state and increase probability of life-threatening risks. Providing proper medical careto patients with comorbidities requires additional economic expenses in the health care system in order to ensure a comprehensive diagnostic procedure and treatment algorithm. To improve the prognosis of patients with comorbidities and reduce the economic burden on the health care system, it is necessary touse a multicomplex approach at the stages of prevention, diagnosis and treatment of major non-communicable diseases that mainly form comorbidity.

show abstract

How can we improve the diagnosis of heart failure?

Cited by 2 publications

References 15 publications

Left Atrioventricular Coupling Index in Heart Failure Patients Using Echocardiography: A Simple Yet Effective Metric

Left Atrioventricular Coupling Index in Heart Failure Patients Using Echocardiography: A Simple Yet Effective Metric

Specificities of Treatment of Patients With Cardiovascular Risk in Comorbidity

Contact Info

Product

Resources

About