2015
DOI: 10.4172/2155-6113.1000440
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How can Improve DNA Vaccine Modalities as a Therapeutic Approach against HIV Infections?

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Cited by 7 publications
(4 citation statements)
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“…They are effective particularly as a key component of HIV vaccination strategies, usually as part of a prime/boost vaccination strategy with viral vector evaluated for both preclinical studies and in Phase I and II clinical trials. Generation of vaccine-specific multifunctional CD8+ T cells would be a major component of an effective vaccine [50].…”
Section: Significance Of Molecular Changes During Infectionmentioning
confidence: 99%
“…They are effective particularly as a key component of HIV vaccination strategies, usually as part of a prime/boost vaccination strategy with viral vector evaluated for both preclinical studies and in Phase I and II clinical trials. Generation of vaccine-specific multifunctional CD8+ T cells would be a major component of an effective vaccine [50].…”
Section: Significance Of Molecular Changes During Infectionmentioning
confidence: 99%
“…Several therapeutic vaccine strategies have already been used such as live-attenuated microbes, viral vectors, and dendritic cell-based vaccines that led to suppress and/or clear infections. Among them, improved DNA vaccines have emerged as a promising candidate for the treatment of infectious diseases especially HIV infections [61][62][63]. Some strategies have been considered to improve immune responses stimulated by DNA vaccines such as in vivo efficient DNA delivery systems, co-delivery with molecular adjuvants as well as the development of potent heterologous prime-boost regimens [61,62,64].…”
Section: Therapeutic Hiv Vaccinesmentioning
confidence: 99%
“…Among them, improved DNA vaccines have emerged as a promising candidate for the treatment of infectious diseases especially HIV infections [61][62][63]. Some strategies have been considered to improve immune responses stimulated by DNA vaccines such as in vivo efficient DNA delivery systems, co-delivery with molecular adjuvants as well as the development of potent heterologous prime-boost regimens [61,62,64]. DNA vaccines have been utilized as candidate HIV vaccines because of their ability to generate cellular and humoral immune responses, the lack of anti-vector response allowing for repeat administration, and their ability to prime the response to viral-vectored vaccines.…”
Section: Therapeutic Hiv Vaccinesmentioning
confidence: 99%
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