How blockchain technology can improve the outcomes of clinical trials

Borioli, Giovanni Scarso; Couturier, Jérôme

doi:10.12968/bjhc.2018.24.3.156

Cited by 17 publications

(5 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some applications are proposed to consolidate patient data for hospital and physician use (OmniPHR by Ekblaw et al 2016), and others are offered as a single source for secure, fast, and transparent access (Medicalchain 2017). Borioli and Couturier (2018) discussed the potential of blockchain to conduct clinical trials using smart contracts, and Mamoshina et al (2018) proposed a roadmap for decentralizing the personal health data ecosystem for drug discovery, biomarker development, and preventative healthcare. MeDShare provides data provenance, auditing, and control of shared medical data in cloud repositories and monitors any malicious use of the data (Xia et al 2017).…”

Section: Prior Research On Blockchain Technology As a Platform For Re...mentioning

confidence: 99%

A Conceptual Model to Share Resources and Align Goals: Building Blockchain Application to Support Care Continuity Outside a Hospital

Tanniru

Woo

Dutta

2023

JRFM

View full text Add to dashboard Cite

The increased use of advanced technologies by consumers and hospitals is moving care closer to patients, and the challenge is one of how patient data can be shared with external care providers and patients. To support care continuity, patient data include both clinical data used by external care providers and non-clinical data used by social care providers. Care coordination of a patient outside a hospital requires peer-to-peer connectivity among a number of these clinical and social care providers, using a digital platform that aligns their goals and assigns their resource sharing responsibilities. With no single entity supporting such care coordination, most hospitals currently distribute this responsibility to several of its provider partners and patients. Such a division of responsibility with no real time feedback leads to discontinuous resource sharing, localized data analysis, and challenges in tailoring care to improve health outcomes. The goal of this paper is to propose a blockchain architecture model that uses a number of constructs for creating and assigning ownership to patient data so it can support peer-to-peer resource sharing and uses smart contracts to support goal alignment. Using two blockchain applications implemented in Hyperledger and illustrating their potential representation using the constructs in multi-chain, we develop a conceptual model for developing blockchain applications in general to support continuity of care. The generalizability of this model is illustrated by applying these constructs to four additional healthcare applications. Finally, we conclude the paper with a discussion of the limitations and directions for future research.

show abstract

Section: Prior Research On Blockchain Technology As a Platform For Re...mentioning

confidence: 99%

A Conceptual Model to Share Resources and Align Goals: Building Blockchain Application to Support Care Continuity Outside a Hospital

Tanniru

Woo

Dutta

2023

JRFM

View full text Add to dashboard Cite

show abstract

“…It can be seen that the CRO plays a vital role in CTs as the clinical study closeout report is generated and verified by them and later send to the sponsor for reporting it to the FDA and IRB. Table 1 summarizes the roles and key responsibilities of these stakeholders [28,29]. The current CT system is centralized around the sponsor and the process is monitored and controlled by the CRO.…”

Section: Figure 2: Different Phases In Ctsmentioning

confidence: 99%

Applications of Blockchain Technology in Clinical Trials: Review and Open Challenges

et al. 2020

View full text Add to dashboard Cite

Blockchain technology has disclosed unprecedented opportunities in the healthcare sector by unlocking the true value of interoperability. Specifically, the striking features of blockchain technology, such as data provenance, transparency, decentralized transaction validation, and immutability can help to compensate for stringent data management issues (e.g., patient recruitment, persistent monitoring, data management, and data analytics and accurate reporting) in clinical trials (CTs). Although several research studies show that blockchain solutions help to improve patient retention, data integrity, privacy, and ensure CTs compliance with regulatory policies, a comprehensive survey on this topic is lacking. In this survey, we provide insights into the adoption of blockchain technology in CTs. We categorize and classify the literature by devising a meticulous taxonomy of the decentralized tasks of CT and practices based on indispensable parameters. Furthermore, we provide insights on works in progress towards deploying blockchain solutions in CTs. Finally, we identify and discuss several challenges that hinder the successful implementation of blockchain technologies in CTs.

show abstract

“…MediBchain is another patient centric healthcare data management system that enables patient data sharing using cryptographic techniques [51]. Borioli and Couturier [52] discuss the potential of blockchain to conduct clinical trials using smart contracts, and Mamoshina et al [53] propose a roadmap for decentralizing the personal health data ecosystem for drug discovery, biomarker development, and preventative healthcare. The use of microscopy sensors that take an image of fingernails for identity authentication was proposed by Lee at al.…”

Section: Blockchain In Healthcarementioning

confidence: 99%

Using Visualization to Build Transparency in a Healthcare Blockchain Application

et al. 2020

View full text Add to dashboard Cite

With patients demanding services to control their own health conditions, hospitals are looking to build agility in delivering care by extending their reach into patient and partner ecosystems and sharing relevant patient data to support care continuity. However, sharing patient data with several external stakeholders outside a hospital network calls for the development of a digital platform that is trusted by both hospitals and stakeholders, given that there is often no single entity supporting such coordination. In this paper, we propose a methodology that uses a blockchain architecture to address the technical challenge of linking disparate systems used by multiple stakeholders and the social challenge of engendering trust by using visualization to bring about transparency in the way in which data are shared. We illustrate this methodology using a pilot implementation. The paper concludes with a discussion and directions for future research and makes some concluding comments.

show abstract

How blockchain technology can improve the outcomes of clinical trials

Cited by 17 publications

References 7 publications

A Conceptual Model to Share Resources and Align Goals: Building Blockchain Application to Support Care Continuity Outside a Hospital

A Conceptual Model to Share Resources and Align Goals: Building Blockchain Application to Support Care Continuity Outside a Hospital

Applications of Blockchain Technology in Clinical Trials: Review and Open Challenges

Using Visualization to Build Transparency in a Healthcare Blockchain Application

Contact Info

Product

Resources

About