How biomimetic nanofibers advance the realm of cutaneous wound management: The state-of-the-art and future prospects

Eslahi, Niloofar; Soleimani, Foad; Lotfi, Roya; Mohandes, Fatemeh; Simchi, Abdolreza; Razavi, Mehdi

doi:10.1016/j.pmatsci.2024.101293

Cited by 3 publications

(9 citation statements)

References 601 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the infiltration of cells into the fibrous structures of LVC and LSC is evident. Interestingly, the presence of the PLA network appears to prevent the detrimental effect of the excessive hydrophilicity of PVA that could have affected the successful attachment of fibroblast cells …”

Section: Resultsmentioning

confidence: 99%

“…In addition, the capability to quantify the variations of the pH and to collect the reliable, interpretable, and reproducible data enables the transmission and analysis of vital signs for telemedicine purpose. 30 As can be seen in Figure 10, curcumin complexes provide a wide color change at different pH values that is easily perceptible by the naked eye. This variation is more pronounced for the LVC samples.…”

Section: Cytocompatibility Of Compositesmentioning

confidence: 98%

“…Interestingly, the presence of the PLA network appears to prevent the detrimental effect of the excessive hydrophilicity of PVA that could have affected the successful attachment of fibroblast cells. 30 3.5. Mechanical Properties of Dry and Wet Samples.…”

Section: Cytocompatibility Of Compositesmentioning

confidence: 99%

“…Additionally, intrinsically brittle components can be infiltrated into the porous ES structure to a desirable extent while preserving the flexibility and conformability of the composite . This technique facilitates the design of a hydrophilic/hydrophobic wound dressing with adjustable hydrophilicity, bioactivity, improved wet mechanical properties, multiple drug delivery, and tunable drug release kinetics, especially for chronic wound healing. , …”

Section: Introductionmentioning

confidence: 99%

“…29 This technique facilitates the design of a hydrophilic/hydrophobic wound dressing with adjustable hydrophilicity, bioactivity, improved wet mechanical properties, multiple drug delivery, and tunable drug release kinetics, especially for chronic wound healing. 24,30 Curcumin, the bioactive polyphenol component of turmeric (Curcuma longa L.), is an auspicious drug historically known to expedite the wound healing process. 31 It has garnered increasing attention in TE thanks to its excellent antioxidant properties, 12 anti-inflammatory activity, 32 ability to block tumor necrosis factor-alpha (TNF-α), 33 promotion of granulation tissue formation and re-epithelialization, 34 and potential to hinder microorganisms' growth.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Engineered Robust Hydrophobic/Hydrophilic Nanofibrous Scaffolds with Drug-Eluting, Antioxidant, and Antimicrobial Capacity

Soleimani,

Pellerin,

Omidfar

et al. 2024

ACS Appl. Bio Mater.

Self Cite

View full text Add to dashboard Cite

Multifunctional nanofibrous architectures have attracted extensive attention for biomedical applications due to their adjustable and versatile properties. Electrospun fabrics stand out as key building blocks for these structures, yet improving their mechanobiological and physicochemical performance is a challenge. Here, we introduce biodegradable engineered hydrophobic/hydrophilic scaffolds consisting of electrospun polylactide nanofibers coated with drug-eluting synthetic (poly(vinyl alcohol)) and natural (starch) polymers. The microstructure of these composite scaffolds was tailored for an increased hydrophilicity, optimized permeability, water retention capacity of up to 5.1 g/g, and enhanced mechanical properties under both dry and wet conditions. Regarding the latter, normalized tensile strengths of up to 32.4 MPa were achieved thanks to the improved fiber interactions and fiber-coating stress transfer. Curcumin was employed as a model drug, and its sustained release in a pure aqueous medium was investigated for 35 days. An in-depth study of the release kinetics revealed the outstanding water solubility and bioavailability of curcumin, owing to its complexation with the hydrophilic polymers and further delineated the role of the hydrophobic nanofibrous network in regulating its release rate. The modified curcumin endowed the composites with antioxidant activities up to 5.7 times higher than that of free curcumin as well as promising anti-inflammatory and bacteriostatic activities. The cytocompatibility and cell proliferation capability on human dermal fibroblasts also evidenced the safe use of the constructs. Finally, the fabrics present pH-responsive color-changing behavior easily distinguishable within the pH range of 5–9. Thus, these designs offer a facile and cost-effective roadmap for the fabrication of smart multifunctional biomaterials, especially for chronic wound healing.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Cytocompatibility Of Compositesmentioning

confidence: 98%

Section: Cytocompatibility Of Compositesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Engineered Robust Hydrophobic/Hydrophilic Nanofibrous Scaffolds with Drug-Eluting, Antioxidant, and Antimicrobial Capacity

Soleimani,

Pellerin,

Omidfar

et al. 2024

ACS Appl. Bio Mater.

Self Cite

View full text Add to dashboard Cite

show abstract

Nature-inspired healing: Biomimetic nanomaterials for advanced wound management

Sarrami-Foroushani,

Yavari,

Zarepour

et al. 2024

Materials Today Sustainability

View full text Add to dashboard Cite

Biomimetic Materials for Skin Tissue Regeneration and Electronic Skin

Youn,

Ki,

Abdelhamid

et al. 2024

Biomimetics

View full text Add to dashboard Cite

Biomimetic materials have become a promising alternative in the field of tissue engineering and regenerative medicine to address critical challenges in wound healing and skin regeneration. Skin-mimetic materials have enormous potential to improve wound healing outcomes and enable innovative diagnostic and sensor applications. Human skin, with its complex structure and diverse functions, serves as an excellent model for designing biomaterials. Creating effective wound coverings requires mimicking the unique extracellular matrix composition, mechanical properties, and biochemical cues. Additionally, integrating electronic functionality into these materials presents exciting possibilities for real-time monitoring, diagnostics, and personalized healthcare. This review examines biomimetic skin materials and their role in regenerative wound healing, as well as their integration with electronic skin technologies. It discusses recent advances, challenges, and future directions in this rapidly evolving field.

show abstract

How biomimetic nanofibers advance the realm of cutaneous wound management: The state-of-the-art and future prospects

Cited by 3 publications

References 601 publications

Engineered Robust Hydrophobic/Hydrophilic Nanofibrous Scaffolds with Drug-Eluting, Antioxidant, and Antimicrobial Capacity

Engineered Robust Hydrophobic/Hydrophilic Nanofibrous Scaffolds with Drug-Eluting, Antioxidant, and Antimicrobial Capacity

Nature-inspired healing: Biomimetic nanomaterials for advanced wound management

Biomimetic Materials for Skin Tissue Regeneration and Electronic Skin

Contact Info

Product

Resources

About