How best to measure cough clinically

Birring, Surinder S.; Spinou, Arietta

doi:10.1016/j.coph.2015.03.003

Cited by 74 publications

(69 citation statements)

References 36 publications

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“…A simple binary questionnaire was the usual method in previous surveys of cough prevalence (i.e., the presence of cough for at least 3 months of the year [36] ), and the lack of clinical validation was the common limitation in previous surveys published so far. [13] As several tools have been recently validated to characterize cough, [37] we suggest more sophisticated tools to be introduced in future epidemiological surveys of cough. Second, the cross-sectional design of the work rendered it impossible to identify causal relationships between cough and potential risk factors.…”

Section: Discussionmentioning

confidence: 99%

Point prevalence and epidemiological characteristics of chronic cough in the general adult population

et al. 2017

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Cough is frequently self-limiting, but may persist longer in certain individuals. Most of previous studies on the epidemiology of chronic cough have only measured period prevalence, and thus have afforded limited information on the burden and natural course. We aimed to investigate the epidemiology of chronic cough by using a point prevalence measure in a large-scale general population.We analyzed cross-sectional data collected from 18,071 adults who participated in the Korean National Health and Nutrition Examination Survey 2010–2012. Presence and duration of current cough was ascertained by structured questionnaires, and cough was classified into acute (<3 weeks), subacute (3–8 weeks), or chronic cough (≥8 weeks). Demographic and clinical parameters were examined in relation to chronic cough.The point prevalences of acute, subacute, and chronic cough were 2.5 ± 0.2%, 0.8 ± 0.1% and 2.6 ± 0.2%, respectively. The proportion of current cough showed a steep decrease after 1 week of duration. However, 2 peaks in the prevalence of current cough were revealed; cough durations of less than 1 week and longer than 1 year were most common (31.1% and 27.7% of current cough, respectively). Subacute and chronic cough were more prevalent in the elderly (≥65 years); the positive associations with older age were independent of other confounders, including current smoking and comorbidities.This is the first report on the epidemiology of cough using a point prevalence measure in a nationally representative population sample. Our findings indicate a high burden of chronic cough among adults with current cough in the community. The dual-peak of cough duration suggested that the pathophysiology of acute and chronic cough may differ. The preponderance of elderly people in the prevalence of chronic cough warrants further investigation. In addition, more sophistication and validation of tools to define chronic cough will help our understanding of the epidemiology.

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Section: Discussionmentioning

confidence: 99%

Point prevalence and epidemiological characteristics of chronic cough in the general adult population

et al. 2017

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“…19 First, cough-related quality of life questionnaires, such as the Leicester Cough Questionnaire (LCQ) and the Cough-specific Quality-of-Life Questionnaire, have been validated for use and translated into various language versions 128182. These are valuable tools, because the major impact of cough is the deterioration in the quality of life, and the treatment goal is to resume a normal daily life but not to completely inhibit the cough reflex.…”

Section: How To Measure Cough Hypersensitivitymentioning

confidence: 99%

“…In a recent survey conducted in Europe, most subjects with chronic cough responded that their cough medication had limited or no effectiveness (57% and 36%, respectively) 18. Substantial medical expenditures may currently be wasted on ineffective drugs, but this also underscores the need to verify the efficacy of current therapeutic tools and strategies using validated measurement tools 19. More importantly, precise pathophysiological mechanisms should be sought to identify novel targets to manage cough hypersensitivity.…”

Section: Introductionmentioning

confidence: 99%

Cough Hypersensitivity Syndrome: A Few More Steps Forward

Song

Morice

2017

Allergy Asthma Immunol Res

112

110

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Cough reflex is a vital protective mechanism against aspiration, but when dysregulated, it can become hypersensitive. In fact, chronic cough is a significant medical problem with a high degree of morbidity. Recently, a unifying paradigm of cough hypersensitivity syndrome has been proposed. It represents a clinical entity in which chronic cough is a major presenting problem, regardless of the underlying condition. Although it remains a theoretical construct, emerging evidence suggests that aberrant neurophysiology is the common etiology of this syndrome. Recent success in randomized clinical trials using a P2X3 receptor antagonist is the first major advance in the therapeutics of cough in the past 30 years; it at last provides a strategy for treating intractable cough as well as an invaluable tool for dissecting the mechanism underpinning cough hypersensitivity. Additionally, several cough measurement tools have been validated for use and will help assess the clinical relevance of cough in various underlying conditions. Along with this paradigm shift, our understanding of cough mechanisms has improved during the past decades, allowing us to continue to take more steps forward in the future.

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“…Experience and validation of these tools in patients with IPF are limited (table 2 provides an overview). By analogy with chronic cough, we would recommend the visual analogue scale to measure the severity of IPF related cough in a clinical setting, as it is fast and easy to use [60]. When designing a clinical trial, validated subjective as well as objective cough outcome measures should be incorporated.…”

Section: Assessment Of Cough In Ipfmentioning

confidence: 99%

Cough in idiopathic pulmonary fibrosis

et al. 2016

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Many patients with idiopathic pulmonary fibrosis (IPF) complain of chronic refractory cough. Chronic cough is a distressing and disabling symptom with a major impact on quality of life. During recent years, progress has been made in gaining insight into the pathogenesis of cough in IPF, which is most probably "multifactorial" and influenced by mechanical, biochemical and neurosensory changes, with an important role for comorbidities as well. Clinical trials of cough treatment in IPF are emerging, and cough is increasingly included as a secondary end-point in trials assessing new compounds for IPF. It is important that such studies include adequate end-points to assess cough both objectively and subjectively. This article summarises the latest insights into chronic cough in IPF. It describes the different theories regarding the pathophysiology of cough, reviews the different methods to assess cough and deals with recent and future developments in the treatment of cough in IPF. @ERSpublications Latest insights into pathophysiology of cough, methods to assess cough and developments in treatment of cough in IPF http://ow.ly/YfVAH

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How best to measure cough clinically

Cited by 74 publications

References 36 publications

Point prevalence and epidemiological characteristics of chronic cough in the general adult population

Point prevalence and epidemiological characteristics of chronic cough in the general adult population

Cough Hypersensitivity Syndrome: A Few More Steps Forward

Cough in idiopathic pulmonary fibrosis

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