How bacteria could cause cancer: one step at a time

Lax, Alistair J.; Thomas, Warren

doi:10.1016/s0966-842x(02)02360-0

Cited by 211 publications

(181 citation statements)

References 52 publications

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“…Inflammation is thought to be involved in carcinogenesis via multiple mechanisms, such as by inducing genomic damage and damage to cellular structures, acceleration of cell substitution, cell cloning, dispersed angiogenesis, and by the generation of a microenvironment that facilitates tissue regeneration [2]. Moreover, one study found that infection may be a main factor that predisposes individuals to liver cancer, and that many bacteria, such as Helicobacter pylori, can cause chronic inflammation that is related to carcinogenesis [3]. In fact, approximately 20% of all cancers in adults result from chronic inflammation due to infection or exposure to other environmental factors [1,4].…”

Section: Introductionmentioning

confidence: 99%

Prostate calculi in cancer and BPH in a cohort of Korean men: presence of calculi did not correlate with cancer risk

Hwang¹,

Choi²,

Im³

et al. 2009

Asian J Androl

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Prostatic calculi are common and are associated with inflammation of the prostate. Recently, it has been suggested that this inflammation may be associated with prostate carcinogenesis. The aim of this study was to investigate the relationship between prostatic calculi and prostate cancer (PCa) in prostate biopsy specimens. We retrospectively analyzed 417 consecutive patients who underwent transrectal ultrasonography (TRUS) and prostate biopsies between January 2005 and January 2008. Based on the biopsy findings, patients were divided into benign prostatic hyperplasia and PCa groups. TRUS was used to detect prostatic calculi and to measure prostate volume. The correlations between PCa risk and age, serum total PSA levels, prostate volume, and prostatic calculi were analyzed. Patient age and PSA, as well as the frequency of prostatic calculi in the biopsy specimens, differed significantly between both the groups (P < 0.05). In the PCa group, the Gleason scores (GSs) were higher in patients with prostatic calculi than in patients without prostatic calculi (P = 0.023). Using multivariate logistic regression analysis, we found that patient age, serum total PSA and prostate volume were risk factors for PCa (P = 0.001), but that the presence of prostatic calculi was not associated with an increased risk of PCa (P = 0.13). In conclusion, although the presence of prostatic calculi was not shown to be a risk factor for PCa, prostatic calculi were more common in patients with PCa and were associated with a higher GS among these men.

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Section: Introductionmentioning

confidence: 99%

Prostate calculi in cancer and BPH in a cohort of Korean men: presence of calculi did not correlate with cancer risk

Hwang¹,

Choi²,

Im³

et al. 2009

Asian J Androl

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“…17,18,19 Bactibilia is associated with higher postoperative infectious complications due which prolonged hospital stay, need for antibiotics based therapy and higher cost. 9,10,11 Widespread and indiscriminate use of antibiotics over the years has altered the sensitivity pattern of microorganisms which necessitates a change in empiric antibiotic policy. 12,13,14 In our study the most common organism was E. coli (38.80%) which is in concordance with that of below mentioned studies by Malik et The sensitivity of E. coli to Amikacin, Gentamicin, Trimethoprim/Sulfametoxazole, imipenem and Ertapenem is 84%, 53.84%, 57.69%, 53.84% and 50% respectively.…”

Section: Resultsmentioning

confidence: 99%

“…6,7,8 Bactibilia is associated with higher postoperative infectious complications due which there is prolonged hospital stay, need for antibiotics based therapy and higher cost. 9,10,11 Widespread and indiscriminate use of antibiotics over the years has altered the sensitivity pattern of microorganisms which necessitates a change in empiric antibiotic policy. 12,13,14 In our area scanty information is available on bactibilia, hence the present study was undertaken to detect the bacterial pathogen from bile and their AST pattern.…”

Section: Introductionmentioning

confidence: 99%

Bacterial Pathogens from Bile and their Antimicrobial Sensitivity Pattern in a Tertiary Care Hospital

Naik¹,

Wyawahare²,

Bhalchandra³

2017

Int.J.Curr.Microbiol.App.Sci

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“…Some bacterial toxins can also interfere with signal transduction of cells and promote occurrence of tumors. For example, toxin of Pasteurella multocida and cytotoxic necrosis factor of Escherichia coli can activate signal transduction of R ho family, causing activation of cyclooxygenase-2, which participates in multiple stage tumor development [28] .…”

Section: N F L U E Nc E O F O R a L M Ic R O O R G A N I S M S A Ndmentioning

confidence: 99%

Research Progress on the Relationship Between Oral Microbial Community and Tumor

Ma¹

2016

Infection International

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Significant progress was observed in studies of the relationship between oral Helicobacter pylori and gastric cancer and tumors. Based on three distinct and close relationships, namely, the relationship between oral H. pylori and gastric cancer, between oral microbial communities and oral squamous cell carcinoma, and between oral microbial communities of human immunodeficiency virus-infected patients and tumors, this work reviews the relationship between oral microbial communities and tumors. This research also provides reference for further analysis of the relationship between oral microorganisms and tumors to realize early diagnosis of tumor patients through detecting oral microorganisms under adjuvant therapy.

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How bacteria could cause cancer: one step at a time

Cited by 211 publications

References 52 publications

Prostate calculi in cancer and BPH in a cohort of Korean men: presence of calculi did not correlate with cancer risk

Prostate calculi in cancer and BPH in a cohort of Korean men: presence of calculi did not correlate with cancer risk

Bacterial Pathogens from Bile and their Antimicrobial Sensitivity Pattern in a Tertiary Care Hospital

Research Progress on the Relationship Between Oral Microbial Community and Tumor

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