How atypical is atypical language dominance?

Knecht, Stefan; Jansen, Andreas; Frank, Andreas; Randenborgh, Jutta van; Sommer, Jens; Kanowski, Martin; Heinze, Hans Jochen

doi:10.1016/s1053-8119(03)00039-9

Cited by 100 publications

(90 citation statements)

References 32 publications

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“…Then, a subset of the participants took part in an fMRI based validation study. This study comprised the assessment of hemispheric dominance for language production, in a set-up employing a mental word generation task known to produce marked lateralization, in both fMRI and fTCD settings, which is in agreement with the lateralization determined by a Wada test (Knecht et al, 2000(Knecht et al, , 2001(Knecht et al, , 2003.…”

Section: Methodsmentioning

confidence: 78%

“…Each laterality index (fMRI LI) was derived by the formula The above method for LI calculation has been applied successfully in several studies (e.g., Knecht et al, 2003;Rutten, Ramsey, van Rijen & van Veelen, 2002) and can be used to reliably identify hemispheric dominance for language. There is a debate, however, regarding the reproducibility of the degree of laterality indicated in the LI values.…”

Section: Calculationsmentioning

confidence: 99%

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Visual half-field experiments are a good measure of cerebral language dominance if used properly: Evidence from fMRI

2008

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Section: Methodsmentioning

confidence: 78%

Section: Calculationsmentioning

confidence: 99%

Visual half-field experiments are a good measure of cerebral language dominance if used properly: Evidence from fMRI

2008

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“…By using the WFU PickAtlas Tool Version, 2.4 (Maldjian et al, 2003), we defined maskvolumes which masked all brain activations except those in the left or right Cg25 7 containing both activated and non-activated voxels in proportions depending on the general activity level of each individual. To take this inter-subject variability into account, we adjusted the threshold for the activation pixels for each subject using a technique that was introduced earlier by a number of other authors in order to improve the robustness of lateralization measures (Fernández et al, 2001;Knecht et al, 2003;Jansen et al, 2006). In a first step, we calculated the means of the 5% highest T-values in the left and right Cg25 regions as defined by the mask.…”

Section: Image Acquisition and Data Analysismentioning

confidence: 99%

Reduced left subgenual anterior cingulate cortical activity during withdrawal-related emotions in melancholic depressed female patients

Baeken

Schuerbeek

Raedt

et al. 2010

Journal of Affective Disorders

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Background: Research regarding the neurocircuitry in mood disorders suggests an important role for affective information processing of the subgenual part of the anterior cingulate cortex (Cg25: Brodmann area 25).Objective: In this study, we focused on Cg25 neuronal responses in depressed females using a paradigm in which emotions are elicited without explicit cognitive control, relying on the salient nature of the mood inducing stimuli eliciting approach-related emotions (like happiness) or withdrawal-related emotions (like disgust).Methods: Twelve treatment-resistant melancholic depressed women and 12 healthy female control subjects were asked to passively view blocks of emotionally valenced baby faces while undergoing functional magnetic resonance imaging (fMRI).Results: Compared to the healthy females, the depressed patients displayed significantly higher bilateral Cg25 neuronal activities in both emotional conditions. In melancholically depressed women, we found significantly less left-sided than right-sided Cg25 neuronal activity during the withdrawal-related emotions, while right-sided Cg25 activity was comparable for both emotional responses.

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“…For language, a number of studies have addressed the funtional topography in subjects with atypical right-hemisphere language dominance (HubrichUngureanu et al, 2002;Staudt et al, 2002;Knecht et al, 2003;Jansen et al, 2004b). The underlying neuroanatomic correlates for attention are largely unknown, however.…”

Section: Theories On Cerebral Lateralizationmentioning

confidence: 99%

Atypical Hemispheric Dominance for Attention: Functional MRI Topography

Flöel

Jansen

Deppe

et al. 2005

J Cereb Blood Flow Metab

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The right hemisphere is predominantly involved in tasks associated with spatial attention. However, left hemispheric dominance for spatial attention can be found in healthy individuals, and both spatial attention and language can be lateralized to the same hemisphere. Little is known about the underlying regional distribution of neural activation in these 'atypical' individuals. Previously a large number of healthy subjects were screened for hemispheric dominance of visuospatial attention and language, using functional Doppler ultrasonography. From this group, subjects were chosen who were 'atypical' for hemispheric dominance of visuospatial attention and language, and their pattern of brain activation was studied with functional magnetic resonance imaging during a task probing spatial attention. Right-handed subjects with the 'typical' pattern of brain organization served as control subjects. It was found that subjects with an inverted lateralization of language and spatial attention (language right, attention left) recruited left-hemispheric areas in the attention task, homotopic to those recruited by control subjects in the right hemisphere. Subjects with lateralization of both language and attention to the right hemisphere activated an attentional network in the right hemisphere that was comparable to control subjects. The present findings suggest that not the hemispheric side, but the intrahemispheric pattern of activation is the distinct feature for the neural processes underlying language and attention.

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How atypical is atypical language dominance?

Cited by 100 publications

References 32 publications

Visual half-field experiments are a good measure of cerebral language dominance if used properly: Evidence from fMRI

Visual half-field experiments are a good measure of cerebral language dominance if used properly: Evidence from fMRI

Reduced left subgenual anterior cingulate cortical activity during withdrawal-related emotions in melancholic depressed female patients

Atypical Hemispheric Dominance for Attention: Functional MRI Topography

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