How alcohol drinking affects our genes: an epigenetic point of view

Ciafrè, Stefania; Carito, Valentina; Ferraguti, Giampiero; Greco, Antonio; Chaldakov, George N.; Fiore, M.; Ceccanti, Mauro

doi:10.1139/bcb-2018-0248

Cited by 48 publications

(28 citation statements)

References 164 publications

(168 reference statements)

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“…Chronic alcohol consumption represents, in many countries, a social and public health problem. Scientific research has constantly focused on finding solutions not only for the management of psychological dependence but also for the treatment of the numerous pathologies resulting from the abuse of alcohol [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress inhibition by resveratrol in alcohol-dependent mice

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Oxidative stress inhibition by resveratrol in alcohol-dependent mice

et al. 2020

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“…Several human evidences have shown that chronic or binge alcohol consumption as well as alcohol exposure during development are a main inducing-cause of brain changes (110) and mental retardation in both adults and children (88, [111][112][113][114][115][116][117][118][119]. As for the gestational alcohol consumption, the plethora of effects in children induced by ethanol are described as Fetal Alcohol Spectrum Disorders (120)(121)(122)(123).…”

Section: Ngf and Alcohol-induced Mental Retardationmentioning

confidence: 99%

Nerve growth factor in brain diseases

et al. 2018

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The nerve growth factor (NGF) belongs to a family of proteins termed neurotrophins, consisting of NGF, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5 and NT-6. Today, NGF is well recognized to mediate a large number of trophobiological actions resulting in neurotrophic, immunotrophic and/or metabotrophic effects. The pathobiology of neurodegenerative diseases, including Alzheimer disease, psychiatric disorders (e.g. depression and schizophrenia) and brain parasitic infections have in common the effect of altering the brain levels of neurotrophins and in particular NGF. The involvement of NGF and its TrkA receptor in these pathologies and the recent promising results of NGF therapies are presented and discussed.

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“…For this reason, medical authorities recommend no alcohol during pregnancy or while trying to become pregnant; this is important also for the fathers . Indeed, it has been shown that small amounts of alcohol do not cause gross morphological abnormalities, even though they may induce behavioral and memory impairments and reduced brain volume . Alcohol may easily cross the blood brain barrier and both directly and indirectly may disrupt a developing brain affecting brain cell growth, nervous circuitries, and brain areas physiology by potentiating also oxidative stress .…”

Section: Introductionmentioning

confidence: 99%

Fetus morphology changes by second‐trimester ultrasound in pregnant women drinking alcohol

et al. 2019

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Fetal alcohol spectrum disorders (FASDs) are a group of negative conditions occurring in children exposed to alcohol during gestation. The early discovery of FASD is crucial for mother and infant follow-ups. In this study, we investigated in pregnant women the association between urine ethylglucuronide (EtG-a biomarker of alcohol drinking) and indicators of the physical characteristics of FASD by prenatal ultrasound in the second trimester of gestation. We also correlated these data with the AUDIT-C, T-ACE/TACER-3, TWEAK, and food habit diary, screening questionnaires used to disclose alcohol drinking during pregnancy. Forty-four pregnant women were randomly enrolled and examined for ultrasound investigation during the second trimester of gestation. Urine samples were provided by pregnant women immediately after the routine interviews. EtG determinations were performed with a cutoff established at 100 ng/mL, a value indicating occasional alcohol drinking. Fifteen of the enrolled pregnant women overcame the EtG cutoff (34.09%). Analysis of variance (ANOVA) revealed that the fetuses of the positive EtG pregnant women had significantly longer interorbital distance and also significantly increased frontothalamic distance (P's < 0.02). Quite interestingly, no direct correlation was found between EtG data and both food diary and AUDIT-C. However, a significant correlation was observed between urinary EtG and T-ACE (r = 0.375; P = 0.012) and between urinary EtG and TWEAK (r = 0.512; P < 0.001) and a concordance with all questionnaire for EtG values higher than 500 ng/mL. This study provides clinical evidence that the diagnosis of maternal alcohol consumption during pregnancy by urine EtG may disclose FASD-related damage in the fetus.

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How alcohol drinking affects our genes: an epigenetic point of view

Cited by 48 publications

References 164 publications

Oxidative stress inhibition by resveratrol in alcohol-dependent mice

Oxidative stress inhibition by resveratrol in alcohol-dependent mice

Nerve growth factor in brain diseases

Fetus morphology changes by second‐trimester ultrasound in pregnant women drinking alcohol

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