How Aging Affects Sleep-Dependent Memory Consolidation?

Harand, Caroline; Bertran, Françoise; Doidy, Franck; Guénolé, Fabian; Desgranges, Béatrice; Eustache, Francis; Rauchs, Géraldine

doi:10.3389/fneur.2012.00008

Cited by 59 publications

(35 citation statements)

References 70 publications

(73 reference statements)

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“…In particular, REM sleep favors the consolidation of the encoding context associated to the items (Rauchs et al, 2004). In addition, several studies indicate that sleep-dependent consolidation of episodic memories may be altered in older adults (Harand et al, 2012 for review) and we also reported correlations between sleep parameters and episodic memory performance in mild AD patients (Rauchs et al, 2008; Hot et al, 2011). Retention of recent personal episodic memories (e.g., memories of a recent conversation with a relative) was probed after sleep or an equivalent period of wakefulness in older adults (Aly and Moscovitch, 2010), but this issue has never been addressed in AD patients.…”

Section: Introductionsupporting

confidence: 67%

Retrieval of Recent Autobiographical Memories is Associated with Slow-Wave Sleep in Early AD

Rauchs¹,

Piolino²,

Bertran³

et al. 2013

Front. Behav. Neurosci.

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Autobiographical memory is commonly impaired in Alzheimer’s disease (AD). However, little is known about the very recent past which is though highly important in daily life adaptation. In addition, the impact of sleep disturbances, also frequently reported in AD, on the consolidation, and retrieval of autobiographical memories remains to be assessed. Using an adaptation of the TEMPau task, we investigated the neural substrates of autobiographical memory for recent events and the potential relationship with sleep in 14 patients with mild AD. On day 1, autobiographical memory was explored across three periods: remote (18–30 years), the last 2 years and the last month. After testing, sleep was recorded using polysomnography. The next day, AD patients benefited a resting-state 18FDG-PET scan and a second exploration of autobiographical memory, focusing on the very recent past (today and yesterday). Total recall and episodic recall scores were obtained. In addition, for all events recalled, Remember responses justified by specific factual, spatial, and temporal details were measured using the Remember/Know paradigm. Retrieval of autobiographical memories was impaired in AD, but recall of young adulthood and very recent events was relatively better compared to the two intermediate periods. Recall of recent events (experienced the day and the day preceding the assessment) was correlated with brain glucose consumption in the precuneus and retrosplenial cortex, the calcarine region, the angular gyrus, and lateral temporal areas. AD patients also provided more Justified Remember responses for events experienced the previous-day than for those experienced the day of the assessment. Moreover, Justified Remember responses obtained for events experienced before sleep were positively correlated with the amount of slow-wave sleep. These data provide the first evidence of an association between the ability to retrieve recent autobiographical memories and sleep in mild AD patients.

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Section: Introductionsupporting

confidence: 67%

Retrieval of Recent Autobiographical Memories is Associated with Slow-Wave Sleep in Early AD

Rauchs¹,

Piolino²,

Bertran³

et al. 2013

Front. Behav. Neurosci.

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“…Considering that the major age-related changes in sleep architecture concern SWS and associated SWA, prominent impairments in the consolidation, especially of hippocampus-dependent declarative memory, may be expected (512). Consistent with this notion, aging rats at rest after spatial memory encoding showed weaker reactivations of temporal firing patterns in hippocampal neuron ensembles, and this was associated with diminished spatial memory performance in the Morris Water maze at the final testing day (e.g., Ref.…”

Section: Hippocampus-dependent Declarative Memorymentioning

confidence: 79%

About Sleep's Role in Memory

Rasch

Born

2013

Physiological Reviews

2,112

2,026

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Over more than a century of research has established the fact that sleep benefits the retention of memory. In this review we aim to comprehensively cover the field of "sleep and memory" research by providing a historical perspective on concepts and a discussion of more recent key findings. Whereas initial theories posed a passive role for sleep enhancing memories by protecting them from interfering stimuli, current theories highlight an active role for sleep in which memories undergo a process of system consolidation during sleep. Whereas older research concentrated on the role of rapid-eye-movement (REM) sleep, recent work has revealed the importance of slow-wave sleep (SWS) for memory consolidation and also enlightened some of the underlying electrophysiological, neurochemical, and genetic mechanisms, as well as developmental aspects in these processes. Specifically, newer findings characterize sleep as a brain state optimizing memory consolidation, in opposition to the waking brain being optimized for encoding of memories. Consolidation originates from reactivation of recently encoded neuronal memory representations, which occur during SWS and transform respective representations for integration into long-term memory. Ensuing REM sleep may stabilize transformed memories. While elaborated with respect to hippocampus-dependent memories, the concept of an active redistribution of memory representations from networks serving as temporary store into long-term stores might hold also for non-hippocampus-dependent memory, and even for nonneuronal, i.e., immunological memories, giving rise to the idea that the offline consolidation of memory during sleep represents a principle of long-term memory formation established in quite different physiological systems.

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“…Links observed in young adults between SWS and other cognitive functions such as attention are reduced in older adults (Crenshaw and Edinger, 1999; Duffy et al, 2009), and in one study, SWS-declarative memory relationships observed in young adults were not present in older adults (Scullin, 2013). These findings suggest that sleep’s contribution to maintaining memories may diminish with age (Harand et al, 2012; Pace-Schott and Spencer, 2011). Given the mixed findings in this literature, further research is necessary to determine the nature of sleep-memory relationships across the lifespan.…”

Section: Introductionmentioning

confidence: 92%

Memory improvement via slow-oscillatory stimulation during sleep in older adults

Westerberg

Florczak

Weıntraub

et al. 2015

Neurobiology of Aging

137

125

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We examined the intriguing but controversial idea that disrupted sleep-dependent consolidation contributes to age-related memory decline. Slow-wave activity during sleep may help strengthen neural connections and provide memories with long-term stability, in which case decreased slow-wave activity in older adults could contribute to their weaker memories. One prediction from this account is that age-related memory deficits should be reduced by artificially enhancing slow-wave activity. In young adults, applying transcranial current oscillating at a slow frequency (.75 Hz) during sleep improves memory. Here, we tested whether this procedure can improve memory in older adults. In two sessions separated by 1 week, we applied either slow-oscillatory stimulation or sham stimulation during an afternoon nap in a double-blind, crossover design. Memory tests were administered before and after sleep. A larger improvement in word-pair recall and higher slow-wave activity were observed with slow-oscillatory stimulation than with sham stimulation. This is the first demonstration that this procedure can improve memory in older adults, suggesting that declarative memory performance in older adults is partly dependent on slow-wave activity during sleep.

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How Aging Affects Sleep-Dependent Memory Consolidation?

Cited by 59 publications

References 70 publications

Retrieval of Recent Autobiographical Memories is Associated with Slow-Wave Sleep in Early AD

Retrieval of Recent Autobiographical Memories is Associated with Slow-Wave Sleep in Early AD

About Sleep's Role in Memory

Memory improvement via slow-oscillatory stimulation during sleep in older adults

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