Houttuynia Essential Oil and its Self-Microemulsion Preparation Protect Against LPS-Induced Murine Mastitis by Restoring the Blood–Milk Barrier and Inhibiting Inflammation

Liu, Yuanyuan; Jiang, Yangfu; Yang, Yanfang; Wang, Hongliang; Ye, Jun; Liu, Dongdong; Chen, Yanmin; Lian, Chunfang; Wang, Renyun; Gao, Yue; Meng, Yingying; Gao, Lili

doi:10.3389/fimmu.2022.842189

Cited by 3 publications

(2 citation statements)

References 35 publications

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“…HEO plays an anti-inflammatory role by blocking the activation of MAPK and other inflammatory signaling pathways, as well as the expression of iNOS. The authors concluded that HEO might provide a novel treatment for mastitis [133].…”

Section: In Vivo Studiesmentioning

confidence: 99%

Plant Essential Oils as a Tool in the Control of Bovine Mastitis: An Update

et al. 2023

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Bovine mastitis is a major concern for the dairy cattle community worldwide. Mastitis, subclinical or clinical, can be caused by contagious or environmental pathogens. Costs related to mastitis include direct and indirect losses, leading to global annual losses of USD 35 billion. The primary treatment of mastitis is represented by antibiotics, even if that results in the presence of residues in milk. The overuse and misuse of antibiotics in livestock is contributing to the development of antimicrobial resistance (AMR), resulting in a limited resolution of mastitis treatments, as well as a serious threat for public health. Novel alternatives, like the use of plant essential oils (EOs), are needed to replace antibiotic therapy when facing multidrug-resistant bacteria. This review aims to provide an updated overview of the in vitro and in vivo studies available on EOs and their main components as an antibacterial treatment against a variety of mastitis causing pathogens. There are many in vitro studies, but only several in vivo. Given the promising results of treatments with EOs, further clinical trials are needed.

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Section: In Vivo Studiesmentioning

confidence: 99%

Plant Essential Oils as a Tool in the Control of Bovine Mastitis: An Update

et al. 2023

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“…Studies have shown that allogeneic umbilical cord blood mesenchymal stem cell-derived exosomes alleviated subclinical mastitis in dairy cows [ 142 ]. Anti-inflammatory activity and protection of milk fat barrier integrity has been exhibited by small-molecule compounds in mastitis in recent years [ 143 , 144 , 145 ]. The determination of whether the use of bovine milk exosomes as the delivery vehicle of these small-molecule compounds for the treatment of mastitis can increase the efficacy of treatments and whether it presents a reasonable solution to problems of drug resistance and antibiotic residues in clinical practice remain.…”

Section: Application Prospects Of Exosomes As Drug Delivery Vehicles ...mentioning

confidence: 99%

Exosomes in Mastitis—Research Status, Opportunities, and Challenges

Ren

et al. 2022

Animals

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Mastitis, which affects milk quality and yield, is one of the most common diseases in dairy cows, causing large economic losses. Cow mastitis is classified into clinical and subclinical types. Subclinical mastitis presents without obvious lesions in the udder or noticeable change in milk samples, indicating persistent chronic infection that is difficult to detect and treat. Therefore, finding specific biomarkers is of great significance for the early diagnosis and treatment of subclinical mastitis. As mediators of intercellular communication, exosomes have been shown to be extensively involved in various physiological and pathological processes in the body. Exosomes in milk, blood, and cell supernatant can carry stable cell source-specific nucleic acids, proteins, and metabolites. Hence, exosomes show great application prospects for early diagnosis, targeted therapy, and disease mechanism analysis. In this review, we summarize the biogenesis, biological functions, and methods of isolating and identifying exosomes and review the current status of exosome research related to mastitis. Finally, in view of the application of exosomes to diagnose, treat, and perform disease mechanism analysis in mastitis, deficiencies in recent research on mastitis exosomes are described, and the direction of future exosome research efforts in mastitis is proposed.

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Preparation of Self-microemulsion Solids of Kaempferia galanga (L.) Volatile Oil and Its Effect on Rats with Gastric Ulcer

Liu,

Zhuang

et al. 2023

AAPS PharmSciTech

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Houttuynia Essential Oil and its Self-Microemulsion Preparation Protect Against LPS-Induced Murine Mastitis by Restoring the Blood–Milk Barrier and Inhibiting Inflammation

Cited by 3 publications

References 35 publications

Plant Essential Oils as a Tool in the Control of Bovine Mastitis: An Update

Plant Essential Oils as a Tool in the Control of Bovine Mastitis: An Update

Exosomes in Mastitis—Research Status, Opportunities, and Challenges

Preparation of Self-microemulsion Solids of Kaempferia galanga (L.) Volatile Oil and Its Effect on Rats with Gastric Ulcer

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