Household transmission of COVID-19 cases associated with SARS-CoV-2 delta variant (B.1.617.2): national case-control study

Allen, Hester; Vusirikala, Amoolya; Flannagan, Joe; Twohig, Katherine A.; Zaidi, Asad; Chudasama, Dimple; Lamagni, Theresa; Groves, Natalie; Turner, Charlie; Rawlinson, Christopher; Bernal, Jamie Lopez; Harris, Ross; Charlett, André; Dabrera, Gavin; Kall, Meaghan

doi:10.1016/j.lanepe.2021.100252

Cited by 178 publications

(181 citation statements)

References 8 publications

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“…T19R, G142D, 156del, 157del, R158G, L452R, T478K, D614G, P681R, D950R, P871R, T95I, A222V*, and K417N* (Fig. 6D) [77]. The T478K mutation is found to be more adapted and influences the virus affinity to the human cells, leading toward increased viral infectivity [78].…”

Section: Delta (G/478 Kv1; B16172)mentioning

confidence: 94%

Waves and variants of SARS-CoV-2: understanding the causes and effect of the COVID-19 catastrophe

et al. 2021

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Graphical abstract The coronavirus disease-19 has left a permanent mark on the history of the human race. Severe acute respiratory syndrome coronavirus-2 is a positive-sense single-stranded RNA virus, first reported in Wuhan, China, in December 2019 and from there took over the world. Being highly susceptible to mutations, the virus's numerous variants started to appear, and some were more lethal and infectious than the parent. The effectiveness of the vaccine is also affected severely against the new variant. In this study, the infectious mechanism of the coronavirus is explained with a focus on different variants and their respective mutations, which play a critical role in the increased transmissibility, infectivity, and immune escape of the virus. As India has already faced the second wave of the pandemic, the future outlook on the likeliness of a third wave with respect to the Indian variants such as kappa, delta, and Delta Plus is also discussed. This review article aims to reflect the catastrophe of the variants of SARS-CoV-2 and the possibility of developing even more severe variants in the near future.

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Section: Delta (G/478 Kv1; B16172)mentioning

confidence: 94%

Waves and variants of SARS-CoV-2: understanding the causes and effect of the COVID-19 catastrophe

et al. 2021

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“…Delta became the predominant variant of SARS-CoV-2 in the United States in July 2021. §§§§ The Delta variant is more infectious and is associated with increased risk for hospitalization compared with previous variants ( 7 , 8 ); however, nonpregnant patients are not more likely to have severe outcomes during hospitalization ( 9 ). In this analysis, the association between COVID-19 and stillbirth was stronger during the period of Delta predominance.…”

Section: Discussionmentioning

confidence: 99%

Risk for Stillbirth Among Women With and Without COVID-19 at Delivery Hospitalization — United States, March 2020–September 2021

DeSisto

Wallace

Simeone

et al. 2021

MMWR Morb. Mortal. Wkly. Rep.

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“…Gamma may reduce protection against reinfection by 21%-46%, although, as with Beta, estimates of transmissibility and immune escape are correlated (Faria et al, 2021). Finally, multiple analyses suggest that Delta is at least 60% more transmissible than Alpha (Allen et al, 2021;Dagpunar, 2021), and preliminary results suggest moderately reduced neutralization by convalescent serum (Hoffmann et al, 2021;Planas et al, 2021b).…”

Section: Introductionmentioning

confidence: 99%

Population impact of SARS-CoV-2 variants with enhanced transmissibility and/or partial immune escape

Bushman

Kahn

Taylor

et al. 2021

Cell

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SARS-CoV-2 variants of concern exhibit varying degrees of transmissibility and, in some cases, escape from acquired immunity. Much effort has been devoted to measuring these phenotypes, but understanding their impact on the course of the pandemic-especially that of immune escape-has remained a challenge. Here, we use a mathematical model to simulate the dynamics of wild-type and variant strains of SARS-CoV-2 in the context of vaccine rollout and nonpharmaceutical interventions. We show that variants with enhanced transmissibility frequently increase epidemic severity, whereas those with partial immune escape either fail to spread widely or primarily cause reinfections and breakthrough infections. However, when these phenotypes are combined, a variant can continue spreading even as immunity builds up in the population, limiting the impact of vaccination and exacerbating the epidemic. These findings help explain the trajectories of past and present SARS-CoV-2 variants and may inform variant assessment and response in the future. ll

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Household transmission of COVID-19 cases associated with SARS-CoV-2 delta variant (B.1.617.2): national case-control study

Cited by 178 publications

References 8 publications

Waves and variants of SARS-CoV-2: understanding the causes and effect of the COVID-19 catastrophe

Waves and variants of SARS-CoV-2: understanding the causes and effect of the COVID-19 catastrophe

Risk for Stillbirth Among Women With and Without COVID-19 at Delivery Hospitalization — United States, March 2020–September 2021

Population impact of SARS-CoV-2 variants with enhanced transmissibility and/or partial immune escape

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