This study introduces an innovative paradigm for the development of interactive, userresponsive interior spaces. Historically, the design of interior spaces has been largely disconnected from the preferences and requirements of their occupants, necessitating user adaptation. However, advancements in technology, nanomaterials, and intelligent materials have paved the way for the customization of spaces to align with the individual needs and desires of users. Despite these technological advancements, a practical mechanism for the application of intelligent materials and technologies in the design of user-responsive spaces remains elusive. This study aims to address this gap by developing a novel software solution for the creation of color-responsive interactive spaces. The proposed software employs interactive smart materials, particularly thermochromic pigments, to enable spaces to engage with inhabitants in a dynamic manner. Preliminary findings from the Thermochromic Interior Design (TID) program indicate a consistent physiological response across different environments. Yet, the distinct color dynamics within each space foster a unique interactive experience. This study thus extends the current understanding in the field by proposing a proactive approach to interior design that capitalizes on smart materials and technologies. Furthermore, the research highlights the potential of these technologies in crafting adaptive and personalized spaces, posing a paradigm shift in our interaction with our environment. The adaptability and interactivity facilitated by such spaces could enhance user satisfaction and engagement across various contexts, from residential to commercial.