Household solvent exposures and childhood acute lymphoblastic leukemia

Freedman, D. Michal; Stewart, Patricia; Kleinerman, Ruth A.; Wacholder, Sholom; Hatch, Elizabeth E.; Tarone, Robert E.; Robison, Leslie L.; Linet, Martha S.

doi:10.2105/ajph.91.4.564

Cited by 62 publications

(33 citation statements)

References 22 publications

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“…Two SNPs (rs6214 and rs6218) were identified to be associated with childhood ALL risk. The epidemiologic data showed that more subjects in the case group than those in the control group had parental drinking history and house painting exposure during pregnancy or after birth, which is consistent with previous findings [46,47] indicating that parental alcohol consumption and decoration materials exposure are properly risk factors for childhood ALL. Further analysis between IGF1 3'UTR polymorphisms and parental drinking or house painting history confirmed the gene-environment interaction.…”

Section: Discussionsupporting

confidence: 90%

Interaction Between IGF1 Polymorphisms and the Risk of Acute Lymphoblastic Leukemia in Chinese Children

Lu¹,

Wang²,

He³

et al. 2015

Cell Physiol Biochem

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Background/Aims: IGF1 is a key regulator in cell proliferation and apoptosis, and the 3' un-translated region (3'UTR) of the gene plays an important role in gene expression. For the first time, we explored the relationship between polymorphisms in the IGF1 3'UTR region and the risk of childhood acute lymphoblastic leukemia (ALL). Methods: Questionnaires were applied to collect epidemiological data. The genotypes of IGF1 polymorphisms were tested in a population of 744 ALL patients and 1088 cancer-free controls utilizing Taqman. Cell functional studies included real-time PCR, cell culture and transfection and luciferase assays. Results: We found that rs6214 homozygous AA genotype and rs6218 homozygous CC genotype were significantly associated with increased risk of childhood ALL. In addition, rs6218 CC genotype was associated with increased level of IGF1 mRNA in bone marrow, and the mutation in rs6218 led to aberrant binding capacity of hsa-miR-603 and hsa-miR-3941 in the 3'UTR of IGF1. Conclusion: Polymorphisms of rs6214 and rs6218 in the 3'UTR of IGF1 are associated with childhood ALL susceptibility, and the polymorphism of rs6218 is related with IGF1 expression at mRNA level.

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Section: Discussionsupporting

confidence: 90%

Interaction Between IGF1 Polymorphisms and the Risk of Acute Lymphoblastic Leukemia in Chinese Children

Lu¹,

Wang²,

He³

et al. 2015

Cell Physiol Biochem

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“…Studies have examined the relationship between childhood leukemia and direct exposure to these chemicals (e.g., use of pesticides in the home) (Freedman et al 2001; Lowengart 1987) as well as secondary exposure, such as to parents’ clothing worn in an occupational setting where hydrocarbons are used and brought into the home to be laundered (Buckley et al 1989; Lowengart 1987; Shu et al 1999b). …”

Section: Environmental Factorsmentioning

confidence: 99%

“…Freedman et al (2001) conducted a case-control study of 640 subjects to examine the relationship between parental hobbies and home projects and incidence of childhood leukemia. ALL had a statistically significant association with prenatal exposure to painted homes (> 4 rooms) (OR = 1.7; 95% CI, 1.1–2.7) and to artwork with solvents (OR = 4.1; 95% CI, 1.1–15.1).…”

Section: Environmental Factorsmentioning

confidence: 99%

Risk Factors for Acute Leukemia in Children: A Review

Belson

Kingsley

Holmes

2007

Environ Health Perspect

416

279

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Although overall incidence is rare, leukemia is the most common type of childhood cancer. It accounts for 30% of all cancers diagnosed in children younger than 15 years. Within this population, acute lymphocytic leukemia (ALL) occurs approximately five times more frequently than acute myelogenous leukemia (AML) and accounts for approximately 78% of all childhood leukemia diagnoses. Epidemiologic studies of acute leukemias in children have examined possible risk factors, including genetic, infectious, and environmental, in an attempt to determine etiology. Only one environmental risk factor (ionizing radiation) has been significantly linked to ALL or AML. Most environmental risk factors have been found to be weakly and inconsistently associated with either form of acute childhood leukemia. Our review focuses on the demographics of childhood leukemia and the risk factors that have been associated with the development of childhood ALL or AML. The environmental risk factors discussed include ionizing radiation, non-ionizing radiation, hydrocarbons, pesticides, alcohol use, cigarette smoking, and illicit drug use. Knowledge of these particular risk factors can be used to support measures to reduce potentially harmful exposures and decrease the risk of disease. We also review genetic and infectious risk factors and other variables, including maternal reproductive history and birth characteristics.

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“…A study reported results on home exposure to solvents and childhood ALL (Freedman et al 2001). Only artwork at a frequency of more than four times a month was associated with an increased risk of ALL.…”

Section: Discussionmentioning

confidence: 99%

Maternal Exposure to Occupational Solvents and Childhood Leukemia

Infante‐Rivard

Siemiatycki

Lakhani

et al. 2005

Environ Health Perspect

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Many organic solvents are considered probable carcinogens. We carried out a population-based case–control study including 790 incident cases of childhood acute lymphoblastic leukemia and as many healthy controls, matched on age and sex. Maternal occupational exposure to solvents before and during pregnancy was estimated using the expert method, which involves chemists coding each individual’s job for specific contaminants. Home exposure to solvents was also evaluated. The frequency of exposure to specific agents or mixtures was generally low. Results were generally similar for the period ranging from 2 years before pregnancy up to birth and for the pregnancy period alone. For the former period, the odds ratio (OR), adjusted for maternal age and sex, for any exposure to all solvents together was 1.11 [95% confidence interval (CI), 0.88–1.40]. Increased risks were observed for specific exposures, such as to 1,1,1-trichloroethane (OR = 7.55; 95% CI, 0.92–61.97), toluene (OR = 1.88; 95% CI, 1.01–3.47), and mineral spirits (OR = 1.82; 95% CI, 1.05–3.14). There were stronger indications of moderately increased risks associated with exposure to alkanes (C5–C17; OR = 1.78; 95% CI, 1.11–2.86) and mononuclear aromatic hydrocarbons (OR = 1.64; 95% CI, 1.12–2.41). Risk did not increase with increasing exposure, except for alkanes, where a significant trend (p = 0.04) was observed. Home exposure was not associated with increased risk. Using an elaborate exposure coding method, this study shows that maternal exposure to solvents in the workplace does not seem to play a major role in childhood leukemia.

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Household solvent exposures and childhood acute lymphoblastic leukemia

Cited by 62 publications

References 22 publications

Interaction Between IGF1 Polymorphisms and the Risk of Acute Lymphoblastic Leukemia in Chinese Children

Interaction Between IGF1 Polymorphisms and the Risk of Acute Lymphoblastic Leukemia in Chinese Children

Risk Factors for Acute Leukemia in Children: A Review

Maternal Exposure to Occupational Solvents and Childhood Leukemia

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