Household Pesticides and Risk of Pediatric Brain Tumors

Pogoda, Janice M.; Preston‐Martin, Susan

doi:10.2307/3433900

Cited by 19 publications

(27 citation statements)

References 14 publications

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“…Also, in most studies, the authors provided precise information on the type of exposure (occupational or the use of pesticides in the home or garden, environmental exposure due to living close to an agricultural area, or the intervention of a pest controller outside or inside the home). Fourteen studies23 27 31 32 34–37 46 49 52–54 66 mentioned the class of pesticides used. Briefly, eight concerned the use of an insecticide, herbicide or fungicide by the parents at home or in the garden; three concerned the professional use of an insecticide, herbicide or fungicide, and two concerned herbicide spraying by a pest controller.…”

Section: Resultsmentioning

confidence: 99%

Exposure to pesticides and risk of childhood cancer: a meta-analysis of recent epidemiological studies

Vinson

Merhi

Baldi

et al. 2011

Occupational and Environmental Medicine

116

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Section: Resultsmentioning

confidence: 99%

Exposure to pesticides and risk of childhood cancer: a meta-analysis of recent epidemiological studies

Vinson

Merhi

Baldi

et al. 2011

Occupational and Environmental Medicine

116

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“…Seven of the 16 case-control studies (Bunin et al, 1994;Cordier et al, 1994;Davis et al, 1993;Leiss & Savitz, 1995;Pagoda & Preston-Martin, 1997;Sinks, 1985;Wilkins & Koutras, 1998) reported statistically significant increased risks between pesticide exposures and childhood brain cancer. In addition, 5 of 16 case-control studies (Gold et al, 1979;Hemminki et al, 1981;Kuijten et al, 1992;McCredie et al, 1994;Wilkins & Sinks, 1990) detected increased risks between pesticide exposures and childhood brain cancer.…”

Section: Brain Cancer Zahm and Ward Reviewmentioning

confidence: 95%

Pesticides and Childhood Cancer: An Update of Zahm and Ward's 1998 Review

Infante‐Rivard¹,

Weichenthal²

2007

Journal of Toxicology and Environmental Health, Part B

145

109

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Children are exposed to pesticides through a number of sources, including residential and agricultural applications. Parental occupational exposure to pesticides is also a concern because exposures occurring during pregnancy and carry-home residues also contribute to children's cumulative burden. A number of epidemiological studies consistently reported increased risks between pesticide exposures and childhood leukemia, brain cancer, neuroblastoma, non-Hodgkin's lymphoma, Wilms' tumor, and Ewing's sarcoma. An extensive review of these studies was published in 1998 (Zahm & Ward, 1998). Fifteen case-control studies, 4 cohort studies, and 2 ecological studies have been published since this review, and 15 of these 21 studies reported statistically significant increased risks between either childhood pesticide exposure or parental occupational exposure and childhood cancer. Therefore, one can confidently state that there is at least some association between pesticide exposure and childhood cancer. However, an unambiguous mechanistic cause-and-effect relationship between pesticide exposure and childhood cancer was not demonstrated in these studies, and modifying factors such as genetic predisposition, rarely considered in the reviewed studies, likely play an important role. While the time window of exposure may be a crucial determinant for biological effects associated with pesticide exposure on children, studies have not contributed definitive information on the most vulnerable period. Accurate exposure assessment remains a challenge; future epidemiological studies need to assess gene-environment interactions and use improved exposure measures, including separate parental interviews, specific pesticide exposure questions, and semiquantitative exposure measures that can be used to confirm information obtained through questionnaires.

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“…In regards to the literature, few studies investigated the role of residential maternal exposure to pesticides may play in the occurrence of CBT. Comparison of the findings is complicated as the definitions of the exposure and of the time window of interest used have varied.…”

Section: Introductionmentioning

confidence: 99%

Maternal residential pesticide use during pregnancy and risk of malignant childhood brain tumors: A pooled analysis of the ESCALE and ESTELLE studies (SFCE)

Bagazgoïtia

Bailey

Orsi

et al. 2017

Intl Journal of Cancer

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Some previous epidemiological studies have suggested that pesticide exposure during pregnancy may have a possible role in the development of childhood brain tumors (CBT). We pooled data from two French national population-based, case-control studies to investigate the association between maternal residential use of pesticides during pregnancy and the risk of CBT. The mothers of 437 CBT cases and 3,102 controls aged under 15 years who resided in France at diagnosis/interview, frequency-matched by age and gender, answered a structured telephone interview conducted by trained interviewers. Unconditional logistic regression was used to estimate pooled odds ratio (OR) and 95% confidence intervals (95% CI). CBT was significantly associated with the maternal home use of pesticides during pregnancy (OR 1.4, 95% CI 1.2-1.8) and, more specifically, with insecticide (OR 1.4, 1.2-1.8). We could not draw any conclusions about herbicides and/or fungicides because few women used them during pregnancy and most of these mothers also used insecticides. Although potential recall bias cannot be excluded, our findings of this pooled analysis support the hypothesis that residential maternal use of pesticides during pregnancy and particularly insecticides may increase the risk of CBT. Future investigations to verify these findings and to explore for CBT subtypes and dose-response are necessary to have a better understanding of the possible role of pesticides in etiology of CBT.

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Household Pesticides and Risk of Pediatric Brain Tumors

Cited by 19 publications

References 14 publications

Exposure to pesticides and risk of childhood cancer: a meta-analysis of recent epidemiological studies

Exposure to pesticides and risk of childhood cancer: a meta-analysis of recent epidemiological studies

Pesticides and Childhood Cancer: An Update of Zahm and Ward's 1998 Review

Maternal residential pesticide use during pregnancy and risk of malignant childhood brain tumors: A pooled analysis of the ESCALE and ESTELLE studies (SFCE)

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