Household airborne Penicillium associated with peak expiratory flow variability in asthmatic children

Bundy, Kemp W.; Gent, Janneane F.; Beckett, William S.; Bracken, Michael B.; Belanger, Kathleen; Triche, Elizabeth W.; Leaderer, Brian P.

doi:10.1016/s1081-1206(10)60139-1

Cited by 52 publications

(35 citation statements)

References 32 publications

(26 reference statements)

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“…A prospective study by Bundy et al found indoor Penicillium to be associated with increased peak expiratory flow variability greater than 18.5% (OR 2.4; CI 1.2-4.8). 35 The authors of the review concluded that there was limited evidence of an association between indoor culturable Penicillium exposure and exacerbations in asthmatic children.…”

Section: Indoor Fungal Exposure and Current Asthmamentioning

confidence: 99%

Exposure and Health Effects of Fungi on Humans

Larenas‐Linnemann

Barnes²,

Baxi

et al. 2016

The Journal of Allergy and Clinical Immunology: In Practice

197

123

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Fungi are ubiquitous microorganisms that are present in outdoor and indoor environments. Previous research has found relationships between environmental fungal exposures and human health effects. We reviewed recent articles focused on fungal exposure and dampness as risk factors for respiratory disease development, symptoms and hypersensitivity. In particular, we reviewed the evidence suggesting that early exposure to dampness or fungi is associated with development of asthma and increased asthma morbidity. While outdoor exposure to high concentrations of spores can cause health effects such as asthma attacks in association with thunderstorms, most people appear to be relatively unaffected unless they are sensitized to specific genera. Indoor exposure and dampness, on the other hand, appears to be associated with increased risk of developing asthma in young children and asthma morbidity in individuals who have asthma. These are important issues because they provide a rationale for interventions that might be considered for homes and buildings in which there is increased fungal exposure. In addition to rhinitis and asthma, fungus exposure is associated with a number of other illnesses including allergic bronchopulmonary mycoses, allergic fungal sinusitis and hypersensitivity pneumonitis. Additional research is necessary to establish causality and evaluate interventions for fungal and dampness-related health effects.

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Section: Indoor Fungal Exposure and Current Asthmamentioning

confidence: 99%

Exposure and Health Effects of Fungi on Humans

Larenas‐Linnemann

Barnes²,

Baxi

et al. 2016

The Journal of Allergy and Clinical Immunology: In Practice

197

123

View full text Add to dashboard Cite

show abstract

“…While Penicillium is frequently isolated both in indoor and outdoor environments, 13,15 many studies have focused on the significance of Penicillium as an indoor mold allergen. 11,73,74 Indoor environmental factors, including inadequate heating and ventilation, the presence of pets, water leaks, and low sun exposure, are known to increase the concentrations of airborne Penicillium. 14 Results for Alternaria and Cladosporium spp.…”

Section: Cladosporiummentioning

confidence: 99%

Sensitization to fungal allergens: Resolved and unresolved issues

Fukutomi

Taniguchi

2015

Allergology International

179

136

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Exposure and sensitization to fungal allergens can promote the development and worsening of allergic diseases. Although numerous species of fungi have been associated with allergic diseases in the literature, the significance of fungi from the genera Alternaria, Cladosporium, Penicillium, Aspergillus, and Malassezia has been well documented. However, it should be emphasized that the contribution of different fungal allergens to allergic diseases is not identical, but species-specific. Alternaria and Cladosporium species are considered to be important outdoor allergens, and sensitization and exposure to species of these genera is related to the development of asthma and rhinitis, as well as epidemics of asthma exacerbation, including life-threatening asthma exacerbation. In contrast, xerophilic species of Penicillium and Aspergillus, excluding Aspergillus fumigatus, are implicated in allergic diseases as indoor allergens. A. fumigatus has a high capacity to colonize the bronchial tract of asthmatic patients, causing severe persistent asthma and low lung function, and sometimes leading to allergic bronchopulmonary aspergillosis. Malassezia are common commensals of healthy skin, although they are also associated with atopic dermatitis, especially on the head and neck, but not with respiratory allergies. Despite its importance in the management of allergic diseases, precise recognition of species-specific IgE sensitization to fungal allergens is often challenging because the majority of fungal extracts exhibit broad cross-reactivity with taxonomically unrelated fungi. Recent progress in gene technology has contributed to the identification of specific and cross-reactive allergen components from different fungal sources. However, data demonstrating the clinical relevance of IgE reactivity to these allergen components are still insufficient.

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“…(Salo et al, 2006), Penicillium spp. (Bundy et al, 2009), Cladosporium spp. (Garrett et al, 1998) are also involved in respiratory disorders.…”

Section: Introductionmentioning

confidence: 99%

Microbiological characterization of 3193 French dwellings of Elfe cohort children

Rocchi

Reboux

Frossard

et al. 2015

Science of The Total Environment

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Household airborne Penicillium associated with peak expiratory flow variability in asthmatic children

Abstract: Background-Exposure to airborne fungi has been associated with increased airway hyperreactivity and asthma prevalence.

Cited by 52 publications

References 32 publications

Exposure and Health Effects of Fungi on Humans

Exposure and Health Effects of Fungi on Humans

Sensitization to fungal allergens: Resolved and unresolved issues

Microbiological characterization of 3193 French dwellings of Elfe cohort children

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