Housefly (<i>Musca domestica</i>) larvae powder, preventing oxidative stress injury<i>via</i>regulation of UCP4 and CyclinD1 and modulation of JNK and P38 signaling in APP/PS1 mice

He, Yinru; Yang, Xia; Jiao, Mengya; Anoopkumar‐Dukie, Shailendra; Zeng, Yu; Mei, Hanfang

doi:10.1039/c8fo02052c

Cited by 8 publications

(6 citation statements)

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“…The mechanisms of insect neuroprotective effects include antioxidation [ 87 ], anti-inflammation [ 87 ], cell cycle inhibition [ 87 ], and apoptosis prevention [ 88 ], which can prevent neurodegenerative diseases (e.g., Alzheimer's disease) [ 87 ], Parkinson's disease [ 170 ], Amyotrophic lateral sclerosis [ 228 ], and epilepsy [ 174 ]. Venom immunotherapy is an effective treatment for systemic allergic reactions to Hymenoptera venom.…”

Section: Effects and Consequences Of Using Medicinal Insectsmentioning

confidence: 99%

Unravelling the potential of insects for medicinal purposes – A comprehensive review

Siddiqui

Aidoo³

et al. 2023

Heliyon

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Section: Effects and Consequences Of Using Medicinal Insectsmentioning

confidence: 99%

Unravelling the potential of insects for medicinal purposes – A comprehensive review

Siddiqui

Aidoo³

et al. 2023

Heliyon

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“…Remarkably, the antioxidant capacity of these insects is similar to foods recognized for their high antioxidant levels, such as cucumbers (2.8 mg TE/g), apples—golden delicious (2.2 mg TE/g)—and kiwifruit (2.7 mg TE/g) [ 58 ]. The high antioxidant capacity is associated with the presence of chitin, cuticle proteins, catalase, antibacterial peptides and superoxide dismutase, among others [ 59 ]. Therefore, insect meals could be included in diets as functional ingredients for promoting pet health.…”

Section: Reasons For Using Insects In Pet Foodmentioning

confidence: 99%

Insects as Feed for Companion and Exotic Pets: A Current Trend

Valdés

Villanueva

Durán

et al. 2022

Animals

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The objective of this review was to carry out a comprehensive investigation of the benefits of incorporating insects as a pet food ingredient and the implications this can have in determining a market demand for insect-based pet foods. Black soldier fly larvae (Hermetia illucens), mealworm larvae (Tenebrio molitor) and adult house crickets (Acheta domesticus) are currently used in pet food. These insects are widely fed to exotic pets, mainly in whole, live or dehydrated formats. They are also incorporated as meal or fat and are offered to cats and dogs as dry or wet food and treats. Scientific studies about the use of insects for dog and cat feed are scarce. Most studies are in dogs. Research shows that insect nutrients, mainly amino acids, have high digestibility, are beneficial to health, do not have any detrimental effect on the gut microbiota and are accepted by dogs. In several countries, insects are approved for use in pet food and commercialization has spread throughout the world. Pet owners are willing to try foods made with insect meal for their pets. In conclusion, the use of insects in pet food is a reality that is taking on more and more prominence.

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“…All scheduled experiments were carried out in the morning (8.00-9.00 am) to maintain uniformity with the experiments. The larval extract was dissolved in saline solution and administered orally by gavage using a gastric tube at the dose of 200 mg/kg/day (He, et al, 2019) [33]. Female rats were divided into experimental groups (10 female/each) as shown in the following design (synopsis):…”

Section: Groups Planningmentioning

confidence: 99%

“…Moreover, the larval extract has been reported to be associated with a variety of health therapy including hepatoprotective in hepatic damage induced by carbon tetrachloride in rats (Wang, et al, 2007) [26], antihepatitic B virus in a cell line (Lu, et al, 2014) [27], hyperlipidemia (Ai et al, 2008) [28], antitumor (Cao, et al, 2010) [29], antifungal (Fu, et al, 2009) [30], and anti-inflammatory (Chu, et al, 2011) [31], in addition to their capacity to ameliorate immunomodulatory proficiency (Cao, et al, 2012) [32]. Recent research has revealed that housefly larvae powder treatment increase protein activities of CAT, SOD, have a protective effect in memory deterioration and may inhibit oxidative stress-induced damage (He, et al, 2019) [33].…”

Section: Introductionmentioning

confidence: 99%

Untitled

2021

Journal of Fertility Sterility and Reproductive Health

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Undoubtedly, numerous bioactive constituents, phytochemicals, and extracts were validated for their health beneficial effects to alleviate complications of Triton-related hypercholesterolemia focusing entirely on hypocholesterolemia, however, ovarian tumours and reproductive disorders, the major risk factors of hypercholesterolemia, was ignored. So, the aim is elaborated to investigate the larva extract of housefly combined with Triton as a preliminary study. The female rats were induced intraperitoneally by 200 mg/kgbw Triton for hypercholesterolemia. The hypercholesterolemic females gave 200mg/kg larval extract orally for improvement activity. In addition to non-lipidemic control and extract-treated group (n = 10/30days). All lipid profile markers, total cholesterol 33.77%, triglycerides 24.95%, and low-density lipoprotein 46.34%, very low-density lipoprotein 59.73%, were significantly decreased in Triton with extract group except the levels of high-density lipoprotein were increased 25%. Besides, the larval extract significantly enhances the depleted ovarian catalase, superoxide dismutase, glutathione peroxidase, glutathione activities and lowers the malondialdehyde levels. The anti-inflammatory effect was enhanced by lowering xanthine oxidase and nitric oxide levels. A corresponding alleviation in ovarian cytotoxicity was noticed in the suppression of lactate dehydrogenase, α-amylase, and myeloperoxidase concentrations. Levels of maternal and embryo-fetal toxicities and fertility were improved in the group of the larval extract with Triton. Concisely, the extract of housefly larvae could attenuate the reproductive and ovarian disorders via retrieving the activities of associated parameters, and that extract can potentially be a promising candidate for human therapeutic development.

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Housefly (Musca domestica) larvae powder, preventing oxidative stress injuryviaregulation of UCP4 and CyclinD1 and modulation of JNK and P38 signaling in APP/PS1 mice

Abstract: Housefly (Musca domestica) Larvae powder (HL) is rich in antioxidants.

Cited by 8 publications

References 40 publications

Unravelling the potential of insects for medicinal purposes – A comprehensive review

Unravelling the potential of insects for medicinal purposes – A comprehensive review

Insects as Feed for Companion and Exotic Pets: A Current Trend

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