House dust mite sensitization in children and residential characteristics in a temperate region

Wickman, Magnus; Nordvall, S. L.; Pershagen, Göran; Sundell, Jan; Schwartz, B.

doi:10.1016/0091-6749(91)90305-8

Cited by 178 publications

(134 citation statements)

References 24 publications

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“…Pollen plants and furred animals were the major sources of sensitisation. The rather low percentage of mite allergy most likely reflects the moderate degree of mite infestation recorded in the Stockholm area (Wickman et al 1991).…”

Section: Discussionmentioning

confidence: 95%

Vernal keratoconjunctivitis in a Stockholm ophthalmic centre ‐ epidemiological, functional, and immunologic investigations

Montan

Ekström²,

Hedlin³

et al. 1999

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To classify a cohort of 62 patients with vernal keratoconjunctivitis (VKC) in immunologic, functional, and epidemiological terms. Methods: A retrospective chart review was conducted to establish the patients' ethnic origin and to ascertain the results of standard in vitro and in vivo testing for atopic allergy. The latter data were compared with tear Phadiatop A , an allergy screening test, in 31 subjects. Further subgroup analyses included methacholine bronchial provocations, serum screening for chlamydial antibodies and epidemiological calculations of the observed prevalence of VKC in the Stockholm area in 1994. Results: Thirty-seven subjects (59.7%) were sensitised to common allergens. No additional allergic subjects were diagnosed with the tear Phadiatop A test. The serology for ocular chlamydial disease was negative. Only 6 out of 17 subjects displayed bronchial reactivity to methacholine of whom 4 had a history of asthma. VKC was clearly more common in individuals with an Asian and African origin. Conclusions: Sensitivity to allergens is a strong determinant for the disease but in a large proportion of the subjects this immunologic abnormality is absent. The varying prevalence of the condition in different ethnic groups indicates a genetic predisposing factor.

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Section: Discussionmentioning

confidence: 95%

Vernal keratoconjunctivitis in a Stockholm ophthalmic centre ‐ epidemiological, functional, and immunologic investigations

Montan

Ekström²,

Hedlin³

et al. 1999

Acta Ophthalmologica Scandinavica

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“…The winters in most parts of Sweden are too cold and dry for mites to survive. Higher levels of mite allergens are therefore only found in homes with increased humidity, possibly as a result of poor ventilation?~, 26 In a German study the cumulative incidence of sensitization to HDMs up to the age 3 years was similar in children who were exposed to mite allergen levels below and above 1.2 ixg/gm. 27 Recently, in another German prospective population-based study of school children, Kuehr et al 2s reported that many of the HDM-sensitized children were exposed to mite allergen levels less than 0.3 ~g/gm dust.…”

Section: Discussionmentioning

confidence: 99%

Exposure to indoor allergens in early infancy and sensitization

Munir¹,

Kjellman²,

Björkstén³

1997

Journal of Allergy and Clinical Immunology

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“…Green et al measured the number of mites in a small sample of household dusl from homes in two Australian towns (one with a humid, coastal climate, and one with a drier, inland climate) on two occasions, 10 years apart, and found a large change (16). House-dust mite infestation has also been shown to have increased in Stockholm (17)(18)(19). It is known that in climates in which house-dust mites exist, dust-mite allergen exposure is the most important risk factor for the development of asthma, and the literature linking mites causally to the disease has been reviewed (20).…”

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confidence: 99%