House Dust Mite Related Allergic Rhinitis and REM Sleep Disturbances

Berson, Shelley R.; Klimczak, Jaclyn; Prezio, Elizabeth A.; Abraham, Manoj T.

doi:10.1016/j.amjoto.2020.102709

Cited by 13 publications

(10 citation statements)

References 45 publications

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“…When considering perennial AR, it is suspected that greater exposure loads to mites and their associated antigens at night, when in contact with mattress and pillows, clearly account for a substantial proportion of the nocturnal symptomatic severity increases 20 with effects on sleep. 22 …”

Section: Diurnal Variation In Ar Symptomsmentioning

confidence: 99%

Allergic rhinitis and sleep disorders in children – coexistence and reciprocal interactions

D’Elia

Gozal

Bruni

et al. 2022

Jornal de Pediatria

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Section: Diurnal Variation In Ar Symptomsmentioning

confidence: 99%

Allergic rhinitis and sleep disorders in children – coexistence and reciprocal interactions

D’Elia

Gozal

Bruni

et al. 2022

Jornal de Pediatria

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“…The epithelial cell-derived cytokines can influence immune cells like dendritic cells and T cells, thus functioning as “master switches” in AR [31]. HDM is an allergen for allergic diseases, including AR [32, 33]. Moreover, in AR mice, this allergen exposure can promote allergic inflammation [25, 34].…”

Section: Discussionmentioning

confidence: 99%

CircARF3 Mitigates Allergic Rhinitis through Targeting microRNA-205-5p/Sirtuin 5 Axis

Zheng

Chen

Zhan

et al. 2023

Int Arch Allergy Immunol

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Introduction: Circular RNAs (circRNAs) are essential in the progression of allergic rhinitis (AR). The purpose of this research was to examine the role of circRNA ADP-ribosylation factor 3 (circARF3) in the pathogenesis of AR. Methods: To generate an animal model of AR, mice were treated with house dust mite (HDM), and mice nasal epithelial cells (NEpCs) were treated with IL-4/IL-13 to imitate the inflammatory damage of AR in vitro. Sanger sequencing, qRT-PCR, and RNAse R digestion assays all validated the circularization structure of circARF3. The levels of circARF3, miR-205-5p, and sirtuin 5 (SIRT5) were determined by qRT-PCR or Western blotting. Luciferase reporter, RNA immunoprecipitation, and pull-down experiments were used to investigate the regulatory network. Flow cytometry was used to investigate the rate of cell apoptosis, and Western blotting was used to determine the levels of apoptotic-related proteins (cleaved caspase 3, cleaved polyadenosine-diphosphate-ribose polymerase) and HMGB1, TLR4, and MyD88. Enzyme-linked immunosorbent assay was used to assess the inflammatory response. Hematoxylin-eosin staining and TUNEL were used to detect the histology of injury and apoptosis of nasal mucosa tissues. Results: CircARF3 and SIRT5 levels were reduced in HDM-treated animals and IL-4/IL-13-treated NEpCs, while miR-205-5p expression was increased. CircARF3 was generated by back-splicing exons 3–5 with a stable circular shape. CircARF3 overexpression mitigated IL-4/IL-13-induced apoptosis in NEpCs by inhibiting miR-205-5p. SIRT5 upregulation attenuated IL-4/IL-13-induced inflammatory injury in NEpCs, and SIRT5 knockdown induced opposite effects. miR-205-5p silencing reversed the effects of SIRT5 knockdown on IL-4/IL-13-induced inflammatory injury. Furthermore, circARF3 overexpression alleviated histological abnormalities, apoptosis, inflammatory response, and HMGB1/TLR4 signaling activation in HDM-treated animals. Conclusion: CircARF3 inhibited cell apoptosis and inflammation via the miR-205-5p/SIRT5 axis in IL-4/IL-13-treated NEpCs and HDM-treated mice.

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“…The data on PSG parameters in adults is mixed. Most studies that perform PSG found that AR worsens PSG parameters 1103,1113–1122 ; however, two studies found either no difference or a modest change 1123,1124 …”

Section: Allergic Rhinitis Disease Burdenmentioning

confidence: 99%

“…However, as the diagnosis of SDB typically relies upon the measurement of all‐night AHI and RDI via polysomnography, many patients with AR and SDB have normal indices by this method. By considering respiratory effort‐related arousals, as well as AHI and RDI measured specifically in REM sleep (REM‐AHI, REM‐RDI), sleep disorders in AR patients will be detected more often 1121 …”

Section: Associated Conditionsmentioning

confidence: 99%

International consensus statement on allergy and rhinology: Allergic rhinitis – 2023

Wise

Damask

Roland

et al. 2023

Int Forum Allergy Rhinol

113

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Background In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR‐Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR‐Allergic Rhinitis 2023 update presents 144 individual topics on allergic rhinitis (AR), expanded by over 40 topics from the 2018 document. Originally presented topics from 2018 have also been reviewed and updated. The executive summary highlights key evidence‐based findings and recommendation from the full document. Methods ICAR‐Allergic Rhinitis 2023 employed established evidence‐based review with recommendation (EBRR) methodology to individually evaluate each topic. Stepwise iterative peer review and consensus was performed for each topic. The final document was then collated and includes the results of this work. Results ICAR‐Allergic Rhinitis 2023 includes 10 major content areas and 144 individual topics related to AR. For a substantial proportion of topics included, an aggregate grade of evidence is presented, which is determined by collating the levels of evidence for each available study identified in the literature. For topics in which a diagnostic or therapeutic intervention is considered, a recommendation summary is presented, which considers the aggregate grade of evidence, benefit, harm, and cost. Conclusion The ICAR‐Allergic Rhinitis 2023 update provides a comprehensive evaluation of AR and the currently available evidence. It is this evidence that contributes to our current knowledge base and recommendations for patient evaluation and treatment.

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House Dust Mite Related Allergic Rhinitis and REM Sleep Disturbances

Cited by 13 publications

References 45 publications

Allergic rhinitis and sleep disorders in children – coexistence and reciprocal interactions

Allergic rhinitis and sleep disorders in children – coexistence and reciprocal interactions

CircARF3 Mitigates Allergic Rhinitis through Targeting microRNA-205-5p/Sirtuin 5 Axis

International consensus statement on allergy and rhinology: Allergic rhinitis – 2023

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