House dust mite–induced asthma causes oxidative damage and DNA double-strand breaks in the lungs

Abstract

This work calls attention to reactive oxygen and nitrogen species and HDM-induced cytotoxicity and to a potential role for DNA repair as a modulator of asthma-associated pathophysiology.

Oxidized CaMKII promotes asthma through the activation of mast cells

“…ROS plays a significant role in pollen-induced (7) or HDM-induced (8) allergic sensitization and asthma. Very recent studies have suggested that HDM can directly induce ROS generation, causing oxidative DNA damage and asthma-associated pathophysiology (8,43). Environmental allergens can either directly induce ROS production or promote local inflammatory processes that lead to the secondary production of ROS (6)(7)(8).…”

“…Very recent studies have suggested that HDM can directly induce ROS generation, causing oxidative DNA damage and asthma-associated pathophysiology (8,43). Environmental allergens can either directly induce ROS production or promote local inflammatory processes that lead to the secondary production of ROS (6)(7)(8). Here, we demonstrated that CRE can induce ROS production and that the production was suppressed in ROS-resistant MMVVδ mice, suggesting that ox-CaMKII may participate in a feed forward circuit to increase ROS production in mast cells.…”

“…Exposure of the airway epithelium to environmental pollutants or allergens is known to induce oxidative stress either directly or through the induction of local inflammatory processes that lead to the secondary production of ROS (6)(7)(8). Previous studies suggest that the multifunctional Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) is within one of the downstream signaling pathways activated by ROS (9).…”

The influence of house dust extract on normal lung cell Mrc5 and non-small lung carcinoma A549

“…Exposure to allergens may also cause a runny nose, fever, or rash. It has also been shown that dust in people with allergic asthma induces an inflammatory response and increases the production of free radicals, leading to oxidative DNA damage and lipid peroxidation [7].…”

Mite allergens

“…They are also risk factors for rhinitis [2] and food-induced anaphylaxis [3]. Some other potential activities have been suggested for HDM or their components, for example, oxidative damage to proteins, lipids, and DNA in lung cells [4] or induction of gastrointestinal inflammation by the enzymatic properties of Der p 1 [5]. Molecular studies have been improved by the production of HDM allergens as recombinant molecules, now available for component resolved diagnosis (CDR) and the designing of potential allergy vaccines.…”