House Dust Mite-Induced Allergic Rhinitis: Is Prevention an Option?

Husain, Salina; Zahedi, Farah Dayana; Mohamad, Sakinah; Abdullah, Baharudin

doi:10.1007/s40521-019-00225-y

Cited by 4 publications

(6 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Allergic rhinitis (AR) is a major public respiratory problem affecting approximately 40% of the worldwide population [1,2]. In Indonesia, the prevalence of AR is 5%-45% of its population, which matches with the prevalence rate in Asia [3].…”

Section: Introductionmentioning

confidence: 83%

“…House dust mite is one of the persistent indoor allergens. Exposure of hypersensitive individuals to house dust mite allergenic protein through the nose can trigger allergic responses, such as AR [1,2,26]. HDM allergenic extracts have been prepared in some countries to help physicians create a precise diagnosis of a patient's allergy [9].…”

Section: Discussionmentioning

confidence: 99%

“…Fifty-six mice were used for the sensitivity test. The animals were divided into seven groups of eight mice each, as follows: (1) Normal group, with NaCl sensitization and challenge; (2)…”

Section: Animals and Groupingmentioning

confidence: 99%

“…Allergic rhinitis is a chronic upper respiratory disease, with inflammation in the nasal mucosa mediated by immunoglobulin E (IgE) [4,5]. House dust mite (HDM) is the characteristic allergic trigger for perennial AR, which occurs throughout the year [2]. The main species of mite is Dermatophagoides pteronyssinus, and Der p1 is its most allergenic protein with protease activity [6].…”

Section: Introductionmentioning

confidence: 99%

“…The early allergic reaction is characterized by sneezing, an itchy nose, and rhinorrhea. The late allergic response is characterized by an increased number of eosinophils, which causes nasal congestion, chronic wheeze, and inflammation [2,7].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Effectiveness of Indonesian house dust mite allergenic extract in triggering allergic rhinitis sensitivity in a mouse model: A preliminary study

et al. 2022

View full text Add to dashboard Cite

Background and Aim: Perennial allergic rhinitis (AR) is a chronic upper respiratory disease, with inflammation mediated by immunoglobulin E in the nasal mucosa caused by house dust mites. Recently, allergen immunotherapy showed promising allergic healing in patients with a definite history of sensitization. Based on this finding, a product was developed using Indonesian house dust mite (IHDM). This study aimed to optimize the allergenic rhinitis mouse model that was generated using IHDM to test the in vivo sensitivity and safety of this product. Materials and Methods: Seven groups of mice were used for effectiveness testing – normal, negative control with IHDM challenge, positive control with 0.1% histamine challenge, and AR group by both IHDM-induced sensitization at 12.5, 50, 250, or 500 μg and IHDM challenge. Mice were sensitized by intraperitoneal administration of IHDM once a week for 3 consecutive weeks. Thereafter, the challenge was given intranasally 5 times on alternate days. The number of nose rubbing and sneezing was noted. Eosinophil infiltration was assessed histologically using hematoxylin and eosin staining. The expression of interleukin-5 (IL-5) mRNA in the nasal mucosa was determined using semi-quantitative reverse transcription-polymerase chain reaction. Results: The induction of AR with IHDM significantly increased the number of nose rubbing and sneezing in the mouse model. Eosinophil infiltration was observed in the nasal mucosa; however, no significant change occurred in the expression of IL-5 mRNA. Conclusion: Overall, these data indicate that IHDM allergenic extract could be an effective sensitizing agent in a mouse model of AR. Although the use of IHDM is a limitation of this study because other sources of house dust mites might have different effects, this study provides a proper model for immunotherapy effectivity testing for in vivo pre-clinical studies.

show abstract

Section: Introductionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

“…Fifty-six mice were used for the sensitivity test. The animals were divided into seven groups of eight mice each, as follows: (1) Normal group, with NaCl sensitization and challenge; (2)…”

Section: Animals and Groupingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effectiveness of Indonesian house dust mite allergenic extract in triggering allergic rhinitis sensitivity in a mouse model: A preliminary study

et al. 2022

View full text Add to dashboard Cite

show abstract

Integrating 16S rRNA Sequencing, Microflora Metabolism, and Network Pharmacology to Investigate the Mechanism of SBL in Alleviating HDM-Induced Allergic Rhinitis

Li,

Hon,

Tsang

et al. 2024

IJMS

View full text Add to dashboard Cite

Allergic rhinitis (AR) is a series of allergic reactions to allergens in the nasal mucosa and is one of the most common allergic diseases that affect both children and adults. Shi-Bi-Lin (SBL) is the modified formula of Cang Er Zi San (CEZS), a traditional Chinese herbal formula used for treating AR. Our study aims to elucidate the anti-inflammatory effects and mechanisms of SBL in house dust mite-induced AR by regulating gut microflora metabolism. In vivo studies showed that nasal allergies and the infiltration of inflammatory cells in the nasal epithelium were significantly suppressed by SBL. Moreover, SBL restored the impaired nasal epithelial barrier function with an increased tight junction protein expression and reduced the endothelial nitric oxide synthase (eNOS). Interestingly, SBL significantly reconstituted the abundance and composition of gut microbiota in AR mice; it increased the relative abundance of potentially beneficial genera and decreased the relative abundance of harmful genera. SBL also restored immune-related metabolisms, which were significantly increased and correlated with suppressing inflammatory cytokines. Furthermore, a network analysis and molecular docking indicated IL-6 was a possible target drug candidate for the SBL treatment. SBL dramatically reduced the IL-6 level in the nasal lavage fluid (NALF), suppressing the IL-6 downstream Erk1/2 and AKT/PI3K signaling pathways. In conclusion, our study integrates 16S rRNA sequencing, microflora metabolism, and network pharmacology to explain the immune mechanism of SBL in alleviating HDM-induced allergic rhinitis.

show abstract

Allergic rhinitis behavioral changes after Indonesian house dust mites allergenic extract administration as immunotherapy

Pratama

Marhaeny

Rohmah

et al. 2023

J. Public Health Afr.

View full text Add to dashboard Cite

Background: Allergy is a hypersensitivity reaction that is generally mediated by Immunoglobulin E (IgE). More than 25% of the world’s population is suspected of having these various diseases, and the prevalence and progression of these diseases have continued to increase significantly in recent years. Among these allergy-related diseases, allergic rhinitis and food allergy are the types of allergies with the highest prevalence. Clinical manifestations of allergic rhinitis include sneezing, rhinorrhea, nasal itching, and nasal congestion. Objective: This study aimed to determine the behavioral changes of allergic rhinitis after Indonesian House Dust Mites (IHDM) allergenic extract administration as an immunotherapy. Methods: Eight male BALB/c mice aged 6-8 weeks in each group were treated for seven groups. The sensitization phase is given intraperitoneal, the desensitization phase is given by subcutaneous, and the challenge phase is given intranasal. The allergic parameters were observed, such as nose rubbing and sneezing. The parameters were observed for 15 minutes after the challenge administration. Results: The results showed that the administration of Indonesian House Dust Mites as immunotherapy decreased the frequency of nose rubbing and sneezing after the administration of immunotherapy compared to the allergic rhinitis model. Conclusions: The administration of the Indonesia House Dust Mites as immunotherapy decreased the allergic rhinitis immune response by altering the behavioral parameter.

show abstract

House Dust Mite-Induced Allergic Rhinitis: Is Prevention an Option?

Cited by 4 publications

References 65 publications

Effectiveness of Indonesian house dust mite allergenic extract in triggering allergic rhinitis sensitivity in a mouse model: A preliminary study

Effectiveness of Indonesian house dust mite allergenic extract in triggering allergic rhinitis sensitivity in a mouse model: A preliminary study

Integrating 16S rRNA Sequencing, Microflora Metabolism, and Network Pharmacology to Investigate the Mechanism of SBL in Alleviating HDM-Induced Allergic Rhinitis

Allergic rhinitis behavioral changes after Indonesian house dust mites allergenic extract administration as immunotherapy

Contact Info

Product

Resources

About