House Dust Mite Allergy Under Changing Environments

Acevedo, Nathalie; Zakzuk, Josefina; Caraballo, Luis

doi:10.4168/aair.2019.11.4.450

Cited by 110 publications

(82 citation statements)

References 125 publications

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“…Not only due to outdoor pollution such as fine dust, harmful solids, liquids, or gases [228], but also due to indoor molds as result of insufficient ventilation in energy efficient homes [229]. Finally, there is a clear increase in the allergen production of house dust mites and pollen leading to more exposure and sensitization in susceptible individuals [230]. All together it must be clear that there is much more known about other causes of increasing allergies worldwide than simply excessive cleanliness as suggested in the hygiene hypothesis.…”

Section: Discussionmentioning

confidence: 99%

A One Health Perspective on the Human–Companion Animal Relationship with Emphasis on Zoonotic Aspects

Overgaauw

Vinke

Hagen

et al. 2020

IJERPH

168

137

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Over time the human–animal bond has been changed. For instance, the role of pets has changed from work animals (protecting houses, catching mice) to animals with a social function, giving companionship. Pets can be important for the physical and mental health of their owners but may also transmit zoonotic infections. The One Health initiative is a worldwide strategy for expanding collaborations in all aspects of health care for humans, animals, and the environment. However, in One Health communications the role of particularly dogs and cats is often underestimated. Objective: Evaluation of positive and negative One Health issues of the human–companion animal relationship with a focus on zoonotic aspects of cats and dogs in industrialized countries. Method: Literature review. Results: Pets undoubtedly have a positive effect on human health, while owners are increasing aware of pet’s health and welfare. The changing attitude of humans with regard to pets and their environment can also lead to negative effects such as changes in feeding practices, extreme breeding, and behavioral problems, and anthropozoonoses. For the human, there may be a higher risk of the transmission of zoonotic infections due to trends such as sleeping with pets, allowing pets to lick the face or wounds, bite accidents, keeping exotic animals, the importation of rescue dogs, and soil contact. Conclusions: One Health issues need frequently re-evaluated as the close human–animal relationship with pet animals can totally differ compared to decennia ago. Because of the changed human–companion animal bond, recommendations regarding responsible pet-ownership, including normal hygienic practices, responsible breeding, feeding, housing, and mental and physical challenges conforming the biology of the animal are required. Education can be performed by vets and physicians as part of the One Health concept.

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Section: Discussionmentioning

confidence: 99%

A One Health Perspective on the Human–Companion Animal Relationship with Emphasis on Zoonotic Aspects

Overgaauw

Vinke

Hagen

et al. 2020

IJERPH

168

137

View full text Add to dashboard Cite

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“…HDMs are major allergens known to induce allergic rhinitis, asthma, and atopic dermatitis. 28 Sensitization to HDM, particularly toDermatophagoides , has increased greatly with rapid industrialization in many countries, [29][30][31][32] as has the prevalence of CU. 3,17 There are several reports on the relationships between HDMs and CU.…”

Section: Discussionmentioning

confidence: 99%

Clustering the clinical course of chronic urticaria using a longitudinal database: Effects on chronic urticaria remission

Yoon

Woo

et al. 2020

Preprint

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Background: Little is known about the clinical course of chronic urticaria (CU) and predictors of its prognosis. We evaluated CU patient clusters based on medication scores for the initial 3 months of treatment to investigate time to remission and relapse rates and to identify predictors for CU remission. Methods: In total, 4552 patients (57.9% female; mean age of 38.6 years) with CU were included in this retrospective cohort study. The K-medoids algorithm was used for clustering CU patients. Kaplan-Meier survival analysis with Cox regression was applied to identify predictors of CU remission. Results: Four distinct clusters were identified: patients with consistently low disease activity (cluster 1, n = 1786), with medium-to-low disease activity (cluster 2, n = 1031), with consistently medium disease activity (cluster 3, n = 1332), or with consistently high disease activity (cluster 4, n = 403). Mean age, treatment duration, peripheral neutrophil counts, total IgE, and complements levels were significantly higher for cluster 4 than the other three clusters. Median times to remission were also different among the four clusters (2.1 vs 3.3 vs 6.4 vs 9.4 years, respectively, P < .001). Sensitization to house dust mites ([?] class 3) and female sex were identified as significant predictors of CU remission. Around 20% of patients who achieved CU remission experienced relapse. Conclusion: In this study, we identified four CU patient clusters by analyzing medication scores during the first 3 months of treatment and found that sensitization to house dust mites and female sex can affect CU prognosis.

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“…Reducing PM2.5 and other air pollution, which increases the inflammatory properties of some allergens, is of great urgency in today's society because it will reduce childhood asthma and even make great contributions to the whole society. [ 66 ] Moreover, education campaigns to teach children about the dangers of smoking have significantly reduced passive and active exposure to tobacco and raised awareness of disease prevention. [ 27 ]…”

Section: The Possibility Of Adjusting the Microbiome To Prevent Asthmmentioning

confidence: 99%

Microecology research: a new target for the prevention of asthma

Shi

Lan

et al. 2020

Chinese Medical Journal

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The incidence and prevalence of asthma have increased remarkably in recent years. There are lots of factors contributing to the occurrence and development of asthma. With the improvement of sequencing technology, it has been found that the microbiome plays an important role in the formation of asthma in early life. The roles of the microbial environment and human microbiome in the occurrence and development of asthma have attracted more and more attention. The environmental microbiome influences the occurrence of asthma by shaping the human microbiome. The specific mechanism may be related to the immune regulation of Toll-like receptors and T cells (special Tregs). Intestinal microbiome is formed and changed by regulating diet and lifestyle in early life, which may affect the development and maturation of the pulmonary immune system through the intestinal-pulmonary axis. It is well-recognized that both environmental microbiomes and human microbiomes can influence the onset of asthma. This review aims to summarize the recent advances in the research of microbiome, its relationship with asthma, and the possible mechanism of the microbiome in the occurrence and development of asthma. The research of the microbial environment and human microbiome may provide a new target for the prevention of asthma in children who have high-risk factors to allergy. However, further study of “when and how” to regulate microbiome is still needed.

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House Dust Mite Allergy Under Changing Environments

Cited by 110 publications

References 125 publications

A One Health Perspective on the Human–Companion Animal Relationship with Emphasis on Zoonotic Aspects

A One Health Perspective on the Human–Companion Animal Relationship with Emphasis on Zoonotic Aspects

Clustering the clinical course of chronic urticaria using a longitudinal database: Effects on chronic urticaria remission

Microecology research: a new target for the prevention of asthma

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