House dust mite allergen immunotherapy for monosensitized versus polysensitized patients with allergic rhinitis: A systematic review and meta-analysis

Phinyo, Phichayut; Krikeerati, Thanachit; Lao-Araya, Mongkol; Thongngarm, Torpong

doi:10.12932/ap-190822-1440

Cited by 2 publications

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“…This trend of polysensitization among dust allergy patients undergoing immunotherapy is consistent with previous studies indicating a shift from monosensitization to polysensitization over time. Notably, polysensitization correlates with increased allergic disease severity, affecting 27.5-74.3% of allergic patients in the US and Europe [17,18]. Despite polysensitization's prevalence, it shouldn't impede immunotherapy, as it has shown beneficial outcomes in both monosensitized and polysensitized patients [17,19].…”

Section: Discussionmentioning

confidence: 99%

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Deciphering Barriers to Immunotherapy: A Comparative Study of Patient Choices in Dust Mite Allergy Management

Ismu Reihan,

Endaryanto,

Umiastuti

et al. 2024

IJRP

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Background: Immunotherapy is still underutilized as an etiologic treatment for house dust mite allergic patients. The reason behind it needs to be explored to improve its availability and effectiveness in treating allergic children.Objective: This study aims to determine the differences in non-clinical and clinical characteristics between pediatric dust allergy patients who received immunotherapy and those who did not receive immunotherapy. Method: This research is a cross-sectional analytical study that aims to compare specific variables that have been determined between HDM allergy patients who underwent immunotherapy and pediatric patients with HDM allergy who did not get immunotherapy. The study involved a total of 180 pediatrics patients with HDM allergies who visited the allergy outpatient clinic at the Department of Pediatrics, Dr. Soetomo General Hospital during the period of January 2018 to December 2021. Data for the study were collected from the existing medical records, followed by data processing and comparative analysis. Result: The total sample was collected as many as 180 pediatric dust allergy patients with 90 patients receiving immunotherapy and 90 patients not receiving immunotherapy. The data analysis using Chi-square test found a significant difference (p < 0.05) between the two groups regarding the clinical diagnosis of rhinitis, clinical diagnosis of sinusitis, skin prick test results for pet and food allergen, local side effects and systemic side effects. However, no significant differences (p > 0.05) were found in the non-clinical characteristics between two sample groups. Conclusion: There were significant differences in the clinical diagnosis of rhinitis, clinical diagnosis of sinusitis, skin prick test result, local side effects and systemic side effects among pediatric patients with HDM allergy who undergo immunotherapy compared to those who only received standard treatment.

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Section: Discussionmentioning

confidence: 99%

“…Notably, polysensitization correlates with increased allergic disease severity, affecting 27.5-74.3% of allergic patients in the US and Europe [17,18]. Despite polysensitization's prevalence, it shouldn't impede immunotherapy, as it has shown beneficial outcomes in both monosensitized and polysensitized patients [17,19].…”

Section: Discussionmentioning

confidence: 99%

Deciphering Barriers to Immunotherapy: A Comparative Study of Patient Choices in Dust Mite Allergy Management

Ismu Reihan,

Endaryanto,

Umiastuti

et al. 2024

IJRP

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“…В отношении влияния АСИТ на объем требуемой медикаментозной терапии БА: получены предположительные данные эффективности (не убедительные) как для моносенсибилизированных, так и для полисенсибилизированных пациентов. В рамках этого метаанализа не оцени-вали закономерности при различных видах сенсибилизации (КДП или иное), а также не проводили анализ эффекта АСИТ на динамику комбинированных индексов, учитывающих симптомы БА и потребность в терапии одновременно [11]. Таким образом, проблема прогнозирования эффективности АСИТ у полисенсибилизированных пациентов с БА требует новых практических данных и клинического осмысления.…”

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The feasibility of allergen-specific immunotherapy for bronchial asthma in children with polysensitization

Trusova,

Kamaev,

Korostovtsev

2024

jour

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Relevance. There is a shortage of studies that would evaluate the effectiveness of allergen immunotherapy (AIT) in children with bronchial asthma (BA) and polysensitization.The aim of the study: to evaluate AIT effectiveness with house dust mite (HDM) allergens in the treatment of BA in children polysensitized to perennial allergens, based on the dynamics of the symptoms and medications score.Materials and methods. The open prospective controlled study included 36 children aged 9,6 [6,9; 12,3] years (from 6 years 1 months to 14 years 3 months) with moderate atopic asthma (21 children (58%) and mild asthma (15 children (42%) and polysensitization to household allergens. Each patient was observed in the study for 4 years: 1 year of preliminary observation and 3 years of sublingual AIT with D. pteronyssinus and D. farinae (Staloral, Stallergenes Greer, France). For each year of observation, asthma symptoms and medications used were assessed, and the combined Score was calculated. To confirm sensitization, a prick test was performed using a standard method with allergens: house dust, D. pteronyssinus, D. farinae, cat, dog, horse, pillow feather (Biomed, Russia).Results. Over 2 years of AIT, the decrease in the symptom and medication Score was 46,9%, and at the end of 3rd year of therapy, 59,8% (р = 0,0001 from baseline). A decrease in the combined Score exceeding 34.9% compared to baseline was noted in all patients in the study.Conclusion. Sublingual AIT with HDM allergens is highly effective in the treatment of asthma in children with domestic polysensitization, in terms of reducing symptoms of the disease, the need for pharmacotherapy and the combined Score of symptoms and medications. A significant positive effect was registered already from the first year of AIT and continues to increase over subsequent years of therapy.

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House dust mite allergen immunotherapy for monosensitized versus polysensitized patients with allergic rhinitis: A systematic review and meta-analysis

Cited by 2 publications

References 0 publications

Deciphering Barriers to Immunotherapy: A Comparative Study of Patient Choices in Dust Mite Allergy Management

Deciphering Barriers to Immunotherapy: A Comparative Study of Patient Choices in Dust Mite Allergy Management

The feasibility of allergen-specific immunotherapy for bronchial asthma in children with polysensitization

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