House dust (1–3)‐<i>β</i>‐<scp>d</scp>‐glucan and wheezing in infants

Iossifova, Yulia; Reponen, Tiina; Bernstein, David I.; Levin, Linda; Kalra, H.; Campo, Paloma; Villareal, Manuel; Lockey, James E.; Hershey, Gurjit K. Khurana; LeMasters, Grace K.

doi:10.1111/j.1398-9995.2007.01340.x

Cited by 99 publications

(117 citation statements)

References 55 publications

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“…EPS are stable carbohydrates secreted or shed during fungal growth and have antigenic specificity at the genus level but cannot represent exposures to all of the fungal species in an indoor environment. Furthermore, it has been suggested that mould-derived components such as (1,3)-b-D-glucan or EPS can protect children from developing allergic disorders, as shown in recent longitudinal investigations [8,9,12]. A protective tendency of mould-derived components on allergic diseases was also confirmed by this study.…”

Section: Discussionsupporting

confidence: 71%

“…While there is a good correlation suggested between visible mould exposure and the concentration of fungal spores [73], recent literature indicated that exposure to mould-derived components might have a different impact on children's health and may not measure a single kind of exposure. This hypothesis was supported by a US cohort study that did not find a correlation between (1,3)-b-D-glucan exposure and visible mould [8,12]. This might be partly due to the fact that (1,3)-b-D-glucan is also part of the structure of plant materials, including pollen and cellulose, as well as soil bacteria; therefore, the level of mould exposure may be overestimated by using (1,3)-b-D-glucan as a surrogate [7].…”

Section: Discussionsupporting

confidence: 62%

“…Visible mould exposure Wheeze Of the nine publications evaluating the longitudinal effect of early exposure to visible mould at home and wheezing in the first 3 yrs of life, seven studies observed a significant positive association [8,12,36,41,42,48,49]. In one US birth cohort study (the Cincinnati Childhood Allergy and Air Pollution Study) from IOSSIFOVA et al [8], the reported increase in risk was persistent from 1-3 yrs of age.…”

Section: Resultsmentioning

confidence: 99%

“…Fungal EPS are stable carbohydrates secreted or shed during fungal growth and have antigenic specificity at the genus level. In contrast to the findings on visible mould, longitudinal studies have shown that exposure to (1,3)-b-D-glucan and EPS was inversely associated with the development of wheezing symptoms and reported physician-diagnosed asthma in children [8][9][10][11][12]. In addition, one case-control study reported that elevated levels of (1,3)-b-D-glucan and EPS exposure from mattress dust were associated with a lower prevalence of allergic sensitisation in 2-4-yr-old children [13].…”

mentioning

confidence: 81%

“…IOSSIFOVA et al [12] reported that exposure to low levels of (1,3)-b-D-glucan from children's primary activity room was associated with a higher risk of recurrent wheeze (OR 3.04 (95% CI 1.25-7.38)) in 1-yr-old children, high levels were protective (OR 0.39 (95% CI 0.16-0.93)). However, this could not be confirmed at 3 yrs of age in the same birth cohort [8].…”

Section: Other Health Outcomesmentioning

confidence: 99%

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Association between domestic mould and mould components, and asthma and allergy in children: a systematic review

Tischer¹,

Cm²,

Heinrich³

2011

European Respiratory Journal

136

108

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Critical reviews over the past 10 yrs have found increased respiratory and allergic health outcomes for children living in damp and mouldy environments. However, recent studies have suggested that early childhood exposure to specific mould components may actually protect children from developing allergy.We conducted a systematic review of observational studies published in English from January 1980 to July 2010. This review was conducted according to systematic guidelines for Metaanalyses of Observational Studies in Epidemiology (MOOSE). The literature was searched using a computerised bibliographic database, PubMed. In order to increase the quality of the reviewed studies, meta-analyses of the effects of visible mould exposure on allergic health outcomes were performed and we evaluated the findings according to the Bradford Hill criteria for evidence of causation.The literature search identified 1,398 peer-reviewed scientific publications, and 61 studies that fulfilled the inclusion criteria were included in this review. We observed increased risks of allergic respiratory health outcomes in children exposed to visible mould and mould spores. These findings were confirmed by the results of the meta-analysis and in line with the evaluation criteria according to Bradford Hill. Visible mould was positively associated with asthma (OR 1.49 (95% CI 1.28-1.72)), wheeze (OR 1.68 (95% CI 1.48-1.90)) and allergic rhinitis (OR 1.39 (95% CI 1.28-1.51)). However, there was a tendency of lower risk for allergic health outcomes in children exposed to mouldderived components such as (1,3)-b-D-glucan and extracellular polysaccharides.These findings suggest that home environments with visible mould and mould spore exposure increase the risk of allergic respiratory health outcomes in children. However, further investigations are needed to examine the effects of exposure to mould-derived components as the current literature is inconclusive. In order to disentangle the different effects of overall microbial exposure on children's health, research should focus on specific microbial markers in the home, in combination with new assessment techniques including molecular methods.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionsupporting

confidence: 62%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 81%

Section: Other Health Outcomesmentioning

confidence: 99%

See 3 more Smart Citations

Association between domestic mould and mould components, and asthma and allergy in children: a systematic review

Tischer¹,

Cm²,

Heinrich³

2011

European Respiratory Journal

136

108

View full text Add to dashboard Cite

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Occupational Microbiological Biohazards – Exposure, Detection, and Disease

Reponen

2021

Patty's Industrial Hygiene

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In this book chapter, sources and characteristics of airborne microbiological contaminants including, bacteria, viruses, and fungi, are discussed in relation to their detection and health effects associated with personal exposure in the occupational environment. The impacts of microorganisms including protists and protozoans and other botanically sourced bioaerosols such as pollen are not reviewed in this book chapter. The potential exposures to microbial bioaerosols and the aerodynamic behavior of these contaminants are reviewed as well as their respiratory and dermal health effects. Direct and indirect sampling methods are presented along with methods of analysis. Methods to prevent personal exposure are also provided.

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Microbial Bioaerosols in the Occupational Environment: Exposure, Detection, and Disease

Reponen¹,

Green²

2012

Patty's Toxicology

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In this chapter, sources and characteristics of airborne microbiological contaminants, including bacteria, viruses, and fungi, are discussed in relation to their detection and health effects associated with personal exposure in the occupational environment. The impacts of microorganisms including protists and protozoans and other botanically sourced bioaerosols such as pollen are not reviewed in this chapter. The potential exposures to microbial bioaerosols and the aerodynamic behavior of these contaminants are reviewed as well as their respiratory and dermal health effects. Direct and indirect sampling methods are presented along with methods of analysis. Methods to prevent personal exposure are also provided.

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House dust (1–3)‐β‐d‐glucan and wheezing in infants

Cited by 99 publications

References 55 publications

Association between domestic mould and mould components, and asthma and allergy in children: a systematic review

Association between domestic mould and mould components, and asthma and allergy in children: a systematic review

Occupational Microbiological Biohazards – Exposure, Detection, and Disease

Microbial Bioaerosols in the Occupational Environment: Exposure, Detection, and Disease

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