HOTAIR/miR-1277-5p/ZEB1 axis mediates hypoxia-induced oxaliplatin resistance via regulating epithelial-mesenchymal transition in colorectal cancer

Weng, Xingyue; Líu, Hao; Ruan, Jian; Du, Miaoyan; Wang, Lingjie; Mao, Jian; Cheng, Ying; Lu, Xuemei; Chen, Wei; Huang, Yaqing; Zhi, Xiao; Shan, Jianzhen

doi:10.1038/s41420-022-01096-0

Cited by 22 publications

(20 citation statements)

References 41 publications

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“…CAFs transfer exosomes miR-92a-3p and lncRNA H19 into CRC cells, activate Wnt/β-catenin, mediate EMT, and promote CRC stemness and 5-FU/OXA resistance ( 135 , 155 ). The hypoxic HOTAIR/miR-1277-5p/ZEB1 axis mediated oxaliplatin resistance in CRC ( 156 , 157 ). Hypoxia can also interact with other mechanisms, such as activating cytochrome P450 subtype CYP3A6 and accelerating drug metabolism; it can also induce ABC transporter upregulation and promote drug efflux ( 158 ).…”

Section: Tcm Reverses the Chemoresistance Of Crc And Inhibits Tumor G...mentioning

confidence: 99%

“…TAM secretes IL-6 and MFG-E8, respectively, activates the IL-6R/ STAT3 and Hedgehog pathways, induces CSCs, and shields CSCs from the cytotoxic effects of 5-FU and cisplatin, resulting in treatment resistance and recurrence (152-154). CAFs transfer exosomes miR-92a-3p and lncRNA H19 into CRC cells, activate Wnt/b-catenin, mediate EMT, and promote CRC stemness and 5-FU/OXA resistance (135,155). The hypoxic HOTAIR/miR-1277-5p/ZEB1 axis mediated oxaliplatin resistance in CRC (156,157).…”

Section: Tumor Microenvironmentmentioning

confidence: 99%

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Research progress of traditional Chinese medicine as sensitizer in reversing chemoresistance of colorectal cancer

Lin

Yang

et al. 2023

Front. Oncol.

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In recent years, the incidences and mortalities from colorectal cancer (CRC) have been increasing; therefore, there is an urgent need to discover newer drugs that enhance drug sensitivity and reverse drug tolerance in CRC treatment. With this view, the current study focuses on understanding the mechanism of CRC chemoresistance to the drug as well as exploring the potential of different traditional Chinese medicine (TCM) in restoring the sensitivity of CRC to chemotherapeutic drugs. Moreover, the mechanism involved in restoring sensitivity, such as by acting on the target of traditional chemical drugs, assisting drug activation, increasing intracellular accumulation of anticancer drugs, improving tumor microenvironment, relieving immunosuppression, and erasing reversible modification like methylation, have been thoroughly discussed. Furthermore, the effect of TCM along with anticancer drugs in reducing toxicity, increasing efficiency, mediating new ways of cell death, and effectively blocking the drug resistance mechanism has been studied. We aimed to explore the potential of TCM as a sensitizer of anti-CRC drugs for the development of a new natural, less-toxic, and highly effective sensitizer to CRC chemoresistance.

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Section: Tcm Reverses the Chemoresistance Of Crc And Inhibits Tumor G...mentioning

confidence: 99%

Section: Tumor Microenvironmentmentioning

confidence: 99%

Research progress of traditional Chinese medicine as sensitizer in reversing chemoresistance of colorectal cancer

Lin

Yang

et al. 2023

Front. Oncol.

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“…Notably, emerging evidence has revealed that lncRNAs could target mRNAs to promote chemoresistance[ 84 ]. For instance, upregulation of the lncRNA HOTAIR has been reported to facilitate EMT in a ZEB1-dependent manner by negatively regulating miR-1277-5p, a process that is involved in hypoxia-induced oxaliplatin resistance[ 85 ]. We previously discovered that metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was overexpressed in CRC tissues compared to paired noncancerous tissues.…”

Section: Overview Of the Regulatory Roles Of Ncrnas In Crc Oxaliplati...mentioning

confidence: 99%

Emerging roles of non-coding RNAs in colorectal cancer oxaliplatin resistance and liquid biopsy potential

Luo¹,

Wang²,

Zhao³

et al. 2023

World J Gastroenterol

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Colorectal cancer (CRC) is one of the most common malignancies of the digestive tract, with the annual incidence and mortality increasing consistently. Oxaliplatin-based chemotherapy is a preferred therapeutic regimen for patients with advanced CRC. However, most patients will inevitably develop resistance to oxaliplatin. Many studies have reported that non-coding RNAs (ncRNAs), such as microRNAs, long non-coding RNAs, and circular RNAs, are extensively involved in cancer progression. Moreover, emerging evidence has revealed that ncRNAs mediate chemoresistance to oxaliplatin by transcriptional and post-transcriptional regulation, and by epigenetic modification. In this review, we summarize the mechanisms by which ncRNAs regulate the initiation and development of CRC chemoresistance to oxaliplatin. Furthermore, we investigate the clinical application of ncRNAs as promising biomarkers for liquid CRC biopsy. This review provides new insights into overcoming oxaliplatin resistance in CRC by targeting ncRNAs.

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“…LncRNAs change the therapeutic effects of multiple drugs on cancer. LncRNA-Hotair regulates the EMT-related signaling pathway by altering hypoxia-induced oxaliplatin resistance ( 37 ). Overexpression of lncRNA-NORAD affects the EMT process by interacting with hsa-miR-125a-3p, thus promoting the invasion and migration in vitro and in vivo ( 38 ).…”

Section: Lncrnas In Carcinogenesismentioning

confidence: 99%

The role of lncRNAs in the tumor microenvironment and immunotherapy of melanoma

Zhou

Cen

et al. 2022

Front. Immunol.

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Melanoma is one of the most lethal tumors with highly aggressive and metastatic properties. Although immunotherapy and targeted therapy have certain therapeutic effects in melanoma, a significant proportion of patients still have drug resistance after treatment. Recent studies have shown that long noncoding RNAs (lncRNAs) are widely recognized as regulatory factors in cancer. They can regulate numerous cellular processes, including cell proliferation, metastasis, epithelial-mesenchymal transition (EMT) progression and the immune microenvironment. The role of lncRNAs in malignant tumors has received much attention, whereas the relationship between lncRNAs and melanoma requires further investigation. Our review summarizes tumor suppressive and oncogenic lncRNAs closely related to the occurrence and development of melanoma. We summarize the role of lncRNAs in the immune microenvironment, immunotherapy and targeted therapy to provide new targets and therapeutic methods for clinical treatment.

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HOTAIR/miR-1277-5p/ZEB1 axis mediates hypoxia-induced oxaliplatin resistance via regulating epithelial-mesenchymal transition in colorectal cancer

Cited by 22 publications

References 41 publications

Research progress of traditional Chinese medicine as sensitizer in reversing chemoresistance of colorectal cancer

Research progress of traditional Chinese medicine as sensitizer in reversing chemoresistance of colorectal cancer

Emerging roles of non-coding RNAs in colorectal cancer oxaliplatin resistance and liquid biopsy potential

The role of lncRNAs in the tumor microenvironment and immunotherapy of melanoma

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