HOTAIR LncRNA: A novel oncogenic propellant in human cancer

Rajagopal, Taruna; Talluri, Srikanth; Akshaya, R.L.; Dunna, Nageswara Rao

doi:10.1016/j.cca.2019.12.028

Cited by 120 publications

(89 citation statements)

References 207 publications

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“…7 However, in recent years, it is confirmed that lncRNA participates in various biological processes. 8 The abnormal expression of lncRNAs is closely related to various diseases including tumors. 9,10 LINC01094 is proved to be highly expressed in clear cell renal cell carcinoma (ccRCC); knocking down LINC01094 inhibits the growth and metastasis of ccRCC cells.…”

Section: Introductionmentioning

confidence: 99%

<p>LINC01094 Down-Regulates miR-330-3p and Enhances the Expression of MSI1 to Promote the Progression of Glioma</p>

Zhu¹,

Liu²,

Liu³

et al. 2020

CMAR

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Background: This study aims at probing into the expression, function, and mechanism of LINC01094 and miR-330-3p in glioma. Materials and Methods: qRT-PCR was employed to examine LINC01094 and miR-330-3p expressions in gliomas. After gain-of-function and loss-of-function models were constructed, CCK-8 and Transwell assays were used to detect the proliferation, migration and invasion of LN229 and U251 cells, respectively. Additionally, dual luciferase reporter gene assay was utilized to verify the binding site between m4iR-330-3p and LINC01094, miR-330-3p, and the 3ʹUTR of musashi RNA binding protein 1 (MSI1). Then, RNA pull-down, RIP, qRT-PCR and Western blot were employed to detect the regulatory relationships among LINC01094, miR-330-3p, and MSI1. Results: The expression of LINC01094 was elevated in glioma tissues and cell lines, and the high expression of LINC01094 was associated with high grade of glioma. In contrast, miR-330-3p was lowly expressed in glioma tissue. Overexpression of LINC01094 or downregulation of miR-330-3p promoted the proliferation, migration, and invasion of glioma cells, while LINC01094 knockdown or miR-330-3p up-regulation impeded these processes. miR-330-3p was identified as a target miRNA of LINC01094, and it could be negatively regulated by LINC01094. In addition, miR-330-3p antagonized the function of LINC01094 by negatively regulating MSI1. Conclusion: LINC01094 promotes the proliferation, migration, and invasion of glioma cells by adsorbing miR-330-3p and up-regulating the expression of MSI1.

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Section: Introductionmentioning

confidence: 99%

<p>LINC01094 Down-Regulates miR-330-3p and Enhances the Expression of MSI1 to Promote the Progression of Glioma</p>

Zhu¹,

Liu²,

Liu³

et al. 2020

CMAR

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“…Furthermore, HOTAIR induces selective re-targeting of PRC2 and trimethylated H3K27 genome-wide, thus promoting the invasion of breast cancer cells [34]. Consistently, high expression of HOTAIR is associated with a short duration of metastasis-free and overall survival in patients with breast cancer [34,35]. Moreover, the 3 side of HOTAIR binds to corepressor for element-1-silencing transcription factor (CoREST)/repressor element-1 silencing transcription factor (REST) complexes, including lysine-specific demethylase 1 (LSD1), which mediates the demethylation of dimethylated H3K4 (H3K4me2).…”

Section: Antisense Lncrnasmentioning

confidence: 89%

Long Noncoding RNAs Involved in the Endocrine Therapy Resistance of Breast Cancer

Takeiwa

Ikeda

Mitobe

et al. 2020

Cancers

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Long noncoding RNAs (lncRNAs) are defined as RNAs longer than 200 nucleotides that do not encode proteins. Recent studies have demonstrated that numerous lncRNAs are expressed in humans and play key roles in the development of various types of cancers. Intriguingly, some lncRNAs have been demonstrated to be involved in endocrine therapy resistance for breast cancer through their own mechanisms, suggesting that lncRNAs could be promising new biomarkers and therapeutic targets of breast cancer. Here, we summarize the functions and mechanisms of lncRNAs related to the endocrine therapy resistance of breast cancer.

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“…HOTAIR is a lncRNA that is widely studied in the cancer field as an important regulator of epigenetic modification; HOTAIR functions by recruiting chromatin modifying complexes [ 61 , 62 ]. The expression of HOTAIR is upregulated in the PBMCs and serum exosomes of patients with RA compared to those of healthy controls, this upregulated expression promotes the migration of macrophages and enhances the recruitment of macrophages to target tissues [ 51 ].…”

Section: Important Roles Of Lncrnas In Autoimmune Diseasesmentioning

confidence: 99%

Involvement of long noncoding RNAs in the pathogenesis of autoimmune diseases

Zou

2020

Journal of Translational Autoimmunity

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Autoimmune diseases are a group of heterogeneous disorders characterized by damage to various organs caused by abnormal innate and adaptive immune responses. The pathogenesis of autoimmune diseases is extremely complicated and has not yet been fully elucidated. Long noncoding RNAs (lncRNAs), which are defined as transcripts containing more than 200 nucleotides with no protein-coding capacity, are emerging as important regulators of gene expression via epigenetic modification, transcriptional regulation and posttranscriptional regulation. Accumulating evidence has demonstrated that lncRNAs play a key role in the regulation of immunological functions and autoimmunity. In this review, we discuss various molecular mechanisms by which lncRNAs regulate gene expression and recent findings regarding the involvement of lncRNAs in many human autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), idiopathic inflammatory myopathy (IIM), systemic sclerosis (SSc) and Sjögren’s syndrome (pSS).

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HOTAIR LncRNA: A novel oncogenic propellant in human cancer

Cited by 120 publications

References 207 publications

<p>LINC01094 Down-Regulates miR-330-3p and Enhances the Expression of MSI1 to Promote the Progression of Glioma</p>

<p>LINC01094 Down-Regulates miR-330-3p and Enhances the Expression of MSI1 to Promote the Progression of Glioma</p>

Long Noncoding RNAs Involved in the Endocrine Therapy Resistance of Breast Cancer

Involvement of long noncoding RNAs in the pathogenesis of autoimmune diseases

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