HOTAIR Is a Potential Novel Biomarker in Patients with Congenital Heart Diseases

Yu, Jingquan; Mo, Hongdan; Zhao, Suhong; Liang, Shuang; Zhang, Maomao; Yuan, Jie

doi:10.1155/2018/2850657

Cited by 34 publications

(24 citation statements)

References 20 publications

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“…In non-end stage heart failure patients HOTAIR was among a panel of lncRNAs that were significantly modulated ( Greco et al, 2016 ). A protective role of HOTAIR in cardiomyocytes ( Gao et al, 2017 ) and as a circulating biomarker for acute myocardial infarction and congenital heart diseases were also proposed ( Jiang et al, 2018 ). Hotair is 2,148 nucleotides long making the structural determination extremely challenging.…”

Section: Lncrna Structure Determinationmentioning

confidence: 99%

Long Non-coding RNA Structure and Function: Is There a Link?

2018

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RNA has emerged as the prime target for diagnostics, therapeutics and the development of personalized medicine. In particular, the non-coding RNAs (ncRNAs) that do not encode proteins, display remarkable biochemical versatility. They can fold into complex structures and interact with proteins, DNA and other RNAs, modulating the activity, DNA targets or partners of multiprotein complexes. Thus, ncRNAs confer regulatory plasticity and represent a new layer of epigenetic control that is dysregulated in disease. Intriguingly, for long non-coding RNAs (lncRNAs, >200 nucleotides length) structural conservation rather than nucleotide sequence conservation seems to be crucial for maintaining their function. LncRNAs tend to acquire complex secondary and tertiary structures and their functions only impose very subtle sequence constraints. In the present review we will discuss the biochemical assays that can be employed to determine the lncRNA structural configurations. The implications and challenges of linking function and lncRNA structure to design novel RNA therapeutic approaches will also be analyzed.

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Section: Lncrna Structure Determinationmentioning

confidence: 99%

Long Non-coding RNA Structure and Function: Is There a Link?

2018

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“…LncRNA HOX transcript antisense RNA (HOTAIR) is a highly conserved and abundant lncRNA associated with various essential biological processes involved in different diseases. Increased expression of HOTAIR was observed in both plasma and cardiac tissues of patients with cardiac hypertrophy (92,93). In contrast, diabetic mice showed a significant decrease in the expression of HOTAIR in heart tissues.…”

Section: Lncrnas and Circrnas That Sponge Mirna-34 Familymentioning

confidence: 95%

Molecular therapies delaying cardiovascular aging: disease- or health-oriented approaches

et al. 2020

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Regenerative medicine is a new therapeutic modality that aims to mend tissue damage by encouraging the reconstitution of physiological integrity. It represents an advancement over conventional therapies that allow reducing the damage but result in disease chronicization. Age-related decline in spontaneous capacity of repair, especially in organs like the heart that have very limited proliferative capacity, contributes in reducing the benefit of conventional therapy. ncRNAs are emerging as key epigenetic regulators of cardiovascular regeneration. Inhibition or replacement of miRNAs may offer reparative solutions to cardiovascular disease. The first part of this review article is devoted to illustrating novel therapies emerging from research on miRNAs. In the second part, we develop new therapeutic concepts emerging from genetics of longevity. Prolonged survival, as in supercentenarians, denotes an exceptional capacity to repair and cope with risk factors and diseases. These characteristics are shared with offspring, suggesting that the regenerative phenotype is heritable. New evidence indicates that genetic traits responsible for prolongation of health span in humans can be passed to and benefit the outcomes of animal models of cardiovascular disease. Genetic studies have also focused on determinants of accelerated senescence and related druggable targets. Evolutionary genetics assessing the genetic basis of adaptation and comparing successful and unsuccessful genetic changes in response to selection within populations represent a powerful basis to develop novel therapies aiming to prolong cardiovascular and whole organism health.

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“…HOTAIR is another lncRNA known to have prominent roles in PD and heart diseases. It is highly expressed in cardiac tissues and is regulated in plasma and serum samples of patients with congenital heart diseases and acute myocardial infarction [ 188 , 189 ]. HOTAIR supports the stability of LRRK2 expression in PD, and its knockdown in MPP-treated SH-SY5Y cells conferred a protective effect against neuroinflammation [ 190 ].…”

Section: Non-coding Rnas In the Brain-heart Axis In Pdmentioning

confidence: 99%

Non-Coding RNAs in the Brain-Heart Axis: The Case of Parkinson’s Disease

Acharya

Salgado-Somoza

Stefanizzi

et al. 2020

IJMS

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Parkinson’s disease (PD) is a complex and heterogeneous disorder involving multiple genetic and environmental influences. Although a wide range of PD risk factors and clinical markers for the symptomatic motor stage of the disease have been identified, there are still no reliable biomarkers available for the early pre-motor phase of PD and for predicting disease progression. High-throughput RNA-based biomarker profiling and modeling may provide a means to exploit the joint information content from a multitude of markers to derive diagnostic and prognostic signatures. In the field of PD biomarker research, currently, no clinically validated RNA-based biomarker models are available, but previous studies reported several significantly disease-associated changes in RNA abundances and activities in multiple human tissues and body fluids. Here, we review the current knowledge of the regulation and function of non-coding RNAs in PD, focusing on microRNAs, long non-coding RNAs, and circular RNAs. Since there is growing evidence for functional interactions between the heart and the brain, we discuss the benefits of studying the role of non-coding RNAs in organ interactions when deciphering the complex regulatory networks involved in PD progression. We finally review important concepts of harmonization and curation of high throughput datasets, and we discuss the potential of systems biomedicine to derive and evaluate RNA biomarker signatures from high-throughput expression data.

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HOTAIR Is a Potential Novel Biomarker in Patients with Congenital Heart Diseases

Cited by 34 publications

References 20 publications

Long Non-coding RNA Structure and Function: Is There a Link?

Long Non-coding RNA Structure and Function: Is There a Link?

Molecular therapies delaying cardiovascular aging: disease- or health-oriented approaches

Non-Coding RNAs in the Brain-Heart Axis: The Case of Parkinson’s Disease

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