HOTAIR contributes to cell proliferation and metastasis of cervical cancer via targetting <i>miR-23b</i>/MAPK1 axis

Li, Qin; Feng, Yuping; Chen, Xu; Shi, Shuai; Liang, Man; Qiao, Yansong; Wang, Bin; Wang, Pin; Zhu, Zhenggang

doi:10.1042/bsr20171563

Cited by 40 publications

(38 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…*p < 0.05, ***p < 0.001 compared to the negative control. The reduced expression of miR-23b-3p in C33A and CaSki cells observed in the present study is a finding that concurs with that reported by Lui et al 22 and Li et al 23 . Au-Yeung et al 13 found that, in SiHa cells, the silencing of the E6 oncoprotein of HPV16 induces the increased expression of miR-23b-3p and observed that p53 binds to the promoter region of miRNA.…”

Section: Discussionsupporting

confidence: 94%

MiR-23b-3p reduces the proliferation, migration and invasion of cervical cancer cell lines via the reduction of c-Met expression

Campos-Viguri

Peralta‐Zaragoza

Jiménez‐Wences

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Malignant transformation and progression in cancer is associated with the altered expression of multiple miRNAs, which are considered as post-transcriptional regulators of genes participating in various cellular processes. Although, it has been proposed that miR-23b-3p acts as a tumor suppressor in cervical cancer (CC), not all the pathways through which it alters the cellular processes have been described. The present study examines whether miR-23b-3p directly represses the c-Met expression and that consequently modifies the proliferation, migration and invasion of C33A and CaSki cells. c-Met has five microRNA response elements (MREs) for miR-23b-3p in the 3′-UTR region. The ectopic overexpression of miR-23b-3p significantly reduces c-Met expression in C33A and CaSki cells. The overexpression of miR-23b-3p reduces proliferation, migration and invasion of CaSki cells and the proliferation and invasion in C33A cells. In CaSki cells, the activation of Gab1 and Fak, downstream of c-Met, is reduced in response to the overexpression of miR-23b-3p. Together, the results in the present study indicate that miR-23b-3p is a tumor suppressor that modulates the progression of CC via posttranscriptional regulation of the c-Met oncogene. Cervical cancer (CC) is the fourth most common malignancy in women around the world, with 569,847 newly diagnosed cases and 311,365 deaths registered in 2018 1. The late detection of CC increases the risk of metastasis and death, with a third of CC patients diagnosed in the advanced stages of the disease 2. This has driven the search for progression and prognosis markers which enable the improvement of treatment scheme selection. While persistent high-risk human papillomavirus (HR HPV) infection plays a central role in the genesis of CC 3 , other factors also contribute to the origin and progression of this malignancy. Some mutations, modifications in specific and global DNA methylation, changes to the expression profiles of chromatin-modifying enzymes and the aberrant expression of microRNAs (miRNAs) are events frequently detected in CC 4,5. Regulating gene

show abstract

Section: Discussionsupporting

confidence: 94%

MiR-23b-3p reduces the proliferation, migration and invasion of cervical cancer cell lines via the reduction of c-Met expression

Campos-Viguri

Peralta‐Zaragoza

Jiménez‐Wences

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Some of the miRNAs that could influence this pathway in the HPV infected organisms are miR-23b, miR329-3p and miR200c. MiR-23b acts as an inhibitor of metastasis in cervical cancer (Li et al, 2018), while miR-329-3p (Li et al, 2017) and miR-200c (Mei et al, 2018) are known for suppressing the migration of the cells and further invasion by targeting MAPK1 and MAPK4. miR-23b exerts its tumor suppressor function by downregulating the MAPK1 expression, through direct binding to the 3 UTR end of MAPK1.…”

Section: Microrna Modulation Of Mapk/erk Signaling In Hpv Infectionmentioning

confidence: 99%

MicroRNA Involvement in Signaling Pathways During Viral Infection

Barbu

Condrat

Thompson

et al. 2020

Front. Cell Dev. Biol.

107

View full text Add to dashboard Cite

“…CI: confidence interval F I G U R E 3 Forest plot describing the association between homeobox transcript antisense intergenic RNA expression and overall survival in gastric cancer (a), esophageal squamous cell carcinoma (b), colorectal cancer (c), and hepatocellular carcinoma patients (d). CI: confidence interval F I G U R E 4 Funnel plot describing the association between homeobox transcript antisense intergenic RNA expression and overall survival of all patients with digestive system carcinoma Wnt/β-catenin, and PI3K/AKT signaling pathways (H. J Kim et al, 2015;Lee et al, 2016;Q. Li et al, 2018)…”

mentioning

confidence: 99%

The prognostic potential of long noncoding RNA HOTAIR expression in human digestive system carcinomas: A meta‐analysis

Abdeahad

Rezayi

Pashirzad

et al. 2018

Journal Cellular Physiology

View full text Add to dashboard Cite

Homeobox transcript antisense intergenic RNA (HOTAIR), one of the well‐known long noncoding RNAs (lncRNAs), plays an important role in initiation and development of various tumors. Elevated level of HOTAIR is associated with metastatic behavior of primary tumor and poor outcome in several cancers. Therefore, we conducted a meta‐analysis to clearly measure the prognostic impact of HOTAIR in patients with digestive system carcinomas. Fourteen studies including 2,666 patients with five different type of digestive system cancers were selected to be entered in meta‐analysis. Finding demonstrated that HOTAIR overexpression could predict unfavorable outcome in digestive system carcinomas (hazard ratio [HR] = 2.4, 95% confidence interval [CI]: 2.0–2.9; p < 0.001; fixed‐effect model). In stratified analysis, increased level of HOTAIR predicted poor overall survival in gastric cancer (HR = 2.1, 95% CI: 1.6–2.9; p < 0.001), colorectal cancer (HR = 4.1, 95% CI: 1.6–10.2; p = 0.002), esophageal squamous cell carcinoma (HR = 2.3, 95% CI: 1.7–3.0; p < 0.001), and hepatocellular carcinoma (HR = 3.4, 95% CI: 1.9–6.1; p < 0.001). Our meta‐analysis results clearly support the prognostic value of HOTAIR to predict unfavorable prognostic outcomes in diverse digestive system carcinomas.

show abstract

HOTAIR contributes to cell proliferation and metastasis of cervical cancer via targetting miR-23b/MAPK1 axis

Cited by 40 publications

References 47 publications

MiR-23b-3p reduces the proliferation, migration and invasion of cervical cancer cell lines via the reduction of c-Met expression

MiR-23b-3p reduces the proliferation, migration and invasion of cervical cancer cell lines via the reduction of c-Met expression

MicroRNA Involvement in Signaling Pathways During Viral Infection

The prognostic potential of long noncoding RNA HOTAIR expression in human digestive system carcinomas: A meta‐analysis

Contact Info

Product

Resources

About