HOTAIR as a Prognostic Predictor for Diverse Human Cancers: A Meta- and Bioinformatics Analysis

Abstract

Several studies suggest that upregulated expression of the long non-coding RNA HOX transcript antisense RNA (HOTAIR) is a negative predictive biomarker for numerous cancers. Herein, we performed a meta-analysis to further investigate the prognostic value of HOTAIR expression in diverse human cancers. To this end, a systematic literature review was conducted in order to select scientific studies relevant to the association between HOTAIR expression and clinical outcomes, including overall survival (OS), recurrence-free survival (RFS)/disease-free survival (DFS), and progression-free survival (PFS)/metastasis-free survival (MFS) of cancer patients. Collectively, 53 eligible studies including a total of 4873 patients were enrolled in the current meta-analysis. Pooled hazard ratios (HRs) with their corresponding 95% confidence intervals (CIs) were calculated to assess the relationship between HOTAIR and cancer patients’ survival. Elevated HOTAIR expression was found to be significantly associated with OS, RFS/DFS and PFS/MFS in diverse types of cancers. These findings were also corroborated by the results of bioinformatics analysis on overall survival. Therefore, based on our findings, HOTAIR could serve as a potential biomarker for the prediction of cancer patient survival in many different types of human cancers.

Genome-Wide Analysis of the FOXA1 Transcriptional Network Identifies Novel Protein-Coding and Long Noncoding RNA Targets in Colorectal Cancer Cells

“…Not much is known about the 9 noncoding genes we identified as FOXA1 targets, with the exception of the lncRNA HOTAIR. Similar to our findings on FOXA1's role in inhibiting anoikis, which, in turn, would promote metastasis, three of the nine identified targets, LINC00365, HNF1A-AS1, and HOTAIR, were previously implicated in promoting metastasis (50,61,62). In contrast, RPLP0P2 and LINC00589 have been shown to inhibit metastasis in lung cancer (59,63), although their role in CRC remains unknown.…”

The Impact of lncRNAs in Diabetes Mellitus: A Systematic Review and In Silico Analyses

“…Accordingly, Li et al reported this lncRNA was upregulated in liver of two T2DM murine models (db/db and C57BL/6J mice) treated with high-fat diet ( 49 ). Hotair is located within the HOMEOBOX C ( HOXC ) gene cluster on chromosome 12q13.13 and is involved in cellular proliferation, inhibition of apoptosis, genomic instability, angiogenesis, and metastasis ( 90 – 92 ). Moreover, Hotair upregulation promotes hepatic insulin resistance via the Akt/GSK pathway ( 38 ), which might partially explain its association with T2DM.…”

Prognostic value of lncRNA HOTAIR in colorectal cancer : a meta-analysis

“…Liu et al reported that HOTAIR expression was significantly increased in cancer tissues compared with that in normal tissues, and its expression level was a risk factor for OS in patients with cervical cancer [37]. Several other studies also found similar results [38][39][40]. Moreover, there was an obvious relationship between high expression of HOTAIR and clinicopathological parameters, such as venous invasion, advanced tumor infiltration and distant metastasis.…”