Hot water extracts of edible Chrysanthemum morifolium Ramat. exert antidiabetic effects in obese diabetic KK-Ay mice

Abstract

In this study, the antidiabetic effects of a hot water extract of edible Chrysanthemum morifolium Ramat. (HW-ECM) were investigated in type 2 diabetic mice. HW-ECM improved blood glucose levels and insulin resistance and increased adiponectin mRNA expression in adipose tissues and protein concentrations in the plasma. Moreover, it increased adipose mRNA and protein expressions of peroxisome proliferator-activated receptor γ (PPARγ), a regulator of adiponectin transcription, and mRNA expression of its downstream target genes. It also reduced the adipose cell size and attenuated the mRNA expression of pro-inflammatory adipocytokines in adipose tissues. These data presumably indicate a hypoglycemic mechanism of HW-ECM, involving increased PPARγ expression, decreased the adipocyte sizes, and suppression of chronic inflammation in adipose tissues. Finally, elevated adiponectin levels lead to amelioration of insulin resistance and the corresponding hypoglycemic effects. Therefore, HW-ECM indicates its potential as a functional food for type 2 diabetes.

Chrysanthemum morifolium Flower Extract Inhibits Adipogenesis of 3T3-L1 Cells via AMPK/SIRT1 Pathway Activation

“…C. zawadskii extracts inhibited adipogenesis by suppressing the expression of transcriptional factors genes in 3T3-L1 adipocytes [27,28]. Chrysanthemum morifolium is reported to exert a variety of bioactive effects associated with its major components, notably flavonoids and phenolic acids [15][16][17]29]. Nevertheless, information on the anti-obesity effect of C. morifolium remains insufficient.…”

“…It contains major components, such as luteolin, apigenin, and chlorogenic acid [ 11 ], which have been shown to exhibit anti-obesity effects by suppressing weight gain [ 12 , 13 , 14 ]. In particular, extracts of C. morifolium Ramat flower (CF) have demonstrated bioactive properties, including anti-oxidant, anti-diabetic, and hypolipidemic effects [ 11 , 15 , 16 , 17 ], but few studies have evaluated its anti-obesity effects. In this study, we aim to investigate the anti-adipogenic effect of the hot water extract of CF (HCF) in 3T3-L1 adipocytes, and to understand its underlying regulatory mechanisms by focusing on AMPK/SIRT1 activation.…”

Chrysanthemum Leaf Ethanol Extract Prevents Obesity and Metabolic Disease in Diet-Induced Obese Mice via Lipid Mobilization in White Adipose Tissue

“…The flower of chrysanthemum ( Chrysanthemum morifolium Ramat.) is popular worldwide and has demonstrated potential effects against insulin resistance, inflammation, and cardiovascular disease [14,15] that have been associated with its flavonoids, such as luteolin (LU), chlorogenic acid, apigenin, and acacetin [16]. Research shows that LU supplements exert protective effects against obesity and its comorbidities via interplay between the liver and adipose tissue in diet-induced obese mice [17].…”

Extraction of flavonoids from Chrysanthemum morifolium and antitumor activity in vitro

“…The pharmacological activities of Chrysanthemum morifolium include reductive effects on blood lipid, blood sugar ( 38 ) and blood pressure, and anti-oxidative ( 39 ), antitumor ( 40 ), neuroprotective ( 41 ), hepatoprotective ( 42 ) and cardioprotective effects ( 43 ). Through an in vitro antitumor activity test, the present study observed that flavonoids extracted from Chrysanthemum morifolium inhibited the proliferation of MKN45 cells in a dose- and time-dependent manner.…”