Abstract:The viral capsid is a macromolecular complex formed by self-assembled proteins (CPs) which, in many cases, are biopolymers with an identical amino acid sequence. Specific CP-CP interactions drive the capsid self-assembly process. However, it is believed that only a small set of protein-protein interface residues significantly contribute to the formation of the capsid; the so-called "hot-spots". Here, we investigate the effect of in-vitro point-mutations on the Bromoviridae family structure-conserved interface … Show more
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