Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation—Where Are We Now?
Hemlata Patil,
Sateesh Kumar Vemula,
Sagar Narala
et al.
Abstract:Hot-melt extrusion (HME) is a globally recognized, robust, effective technology that enhances the bioavailability of poorly soluble active pharmaceutical ingredients and offers an efficient continuous manufacturing process. The twin-screw extruder (TSE) offers an extremely resourceful customizable mixer that is used for continuous compounding and granulation by using different combinations of conveying elements, kneading elements (forward and reverse configuration), and distributive mixing elements. TSE is thu… Show more
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