Hot-Melt 3D Extrusion for the Fabrication of Customizable Modified-Release Solid Dosage Forms

Abstract

In this work, modified-release solid dosage forms were fabricated by adjusting geometrical properties of solid dosage forms through hot-melt 3D extrusion (3D HME). Using a 3D printer with air pressure driving HME system, solid dosage forms containing ibuprofen (IBF), polyvinyl pyrrolidone (PVP), and polyethylene glycol (PEG) were printed by simultaneous HME and 3D deposition. Printed solid dosage forms were evaluated for their physicochemical properties, dissolution rates, and floatable behavior. Results revealed that IBF content in the solid dosage form could be individualized by adjusting the volume of solid dosage form. IBF was dispersed as amorphous state with enhanced solubility and dissolution rate in a polymer solid dosage form matrix. Due to absence of a disintegrant, sustained release of IBF from printed solid dosage forms was observed in phosphate buffer at pH 6.8. The dissolution rate of IBF was dependent on geometric properties of the solid dosage form. The dissolution rate of IBF could be modified by merging two different geometries into one solid dosage form. In this study, the 3D HME process showed high reproducibility and accuracy for preparing dosage forms. API dosage and release profile were found to be customizable by modifying or combining 3D modeling.

Effects of porosity on drug release kinetics of swellable and erodible porous pharmaceutical solid dosage forms fabricated by hot melt droplet deposition 3D printing

“…The most reported thermal-based ME-AM operations in the pharmaceutical literature are hot melt filament-based extrusion printing (e.g. fused deposition modelling (FDM)) [1][2][3][4][5][6][7][8][9][10][11] and recently developed direct powder extrusion [12][13][14][15] . ME-AM allows for the rapid fabrication of highly tailored, bespoke objects with specific geometries that can fit the purpose of personalised medicines [16][17][18][19][20][21][22] .…”

3D Printing Direct Powder Extrusion in the Production of Drug Delivery Systems: State of the Art and Future Perspectives

“…This bioprinter has also been used to produce raloxifene hydrochloride-loaded implants [ 19 ]. Other 3D printers based on this mechanism are the RegenHU Bioprinter (RegenHU, Villaz-St-Pierre, Switzerland) and the ROKIT INVIVO (ROKIT Healthcare, Seoul, Republic of Korea) ( Figure 3 d), both used in the preparation of different drug delivery systems [ 25 , 39 , 40 , 41 ]. Table 1 summarizes the main characteristics of the 3D printers used in the literature reviewed.…”

Advances in Multifunctional Bioactive Coatings for Metallic Bone Implants

“…Although not extensively explored for the production of bioactive coatings, 3D printing technologies are promising candidates for the development of personalized shelled systems for orthopedic applications or porous scaffolds for controlled drug release [163,164].…”