Hot Glue Gun Releasing Biocompatible Tissue Adhesive

Abstract

Tissue bioadhesives are widely used in dermatology, surgery rooms, and in the field. Despite their advantages over sutures and staples, currently available tissue glues are limited by their mechanical properties and toxicity. Here, a new approach is described for wound closure that is based on a biocompatible, low melting point four-armed N-hydroxy succinimide-modified polycaprolactone (star-PCL-NHS). Star-PCL-NHS is inserted into a hot melt glue gun, melts upon minimal pressure, and is extruded directly onto the wound, where it solidifies, bonding strongly with both edges of the wound. Changes in molecular weight allow control of adhesive strength, melting point, and elasticity properties. In vitro and in vivo evaluations confirm the biocompatibility of this system. The straightforward synthetic scheme and the simple delivery method, combined with the desirable mechanical properties, tunability, and tissue compatibility, are desirable traits in wound management.

Injectable Self‐Healing Natural Biopolymer‐Based Hydrogel Adhesive with Thermoresponsive Reversible Adhesion for Minimally Invasive Surgery

“…[ 6 ] Synthetic‐based adhesives, particularly the commonly used cyanoacrylates, exhibit stronger adhesion strength with respect to tissues; however, they have low biocompatibility and biodegradability and trigger excessive host inflammatory response due to the toxic degraded products. [ 7,8 ] Due to the limitations of these clinically used adhesives/sealants, the adoption of substitutive and more effective surgical adhesive or sealant is still anticipated.…”

A Janus Hydrogel Wet Adhesive for Internal Tissue Repair and Anti‐Postoperative Adhesion

“…However, stitching suffers several disadvantages such as time-consuming and difficult operation, secondary damage to the tissues during the sewing process. [1] Recently, tissue adhesives have gained great attention as promising alternatives to surgical suture due to simple deployment, time-saving operation and avoidance of suture related complications. [2,3] Although numerous bioadhesives have been reported thus far, they are almost designed tissue, [1,41] introduction of hydrophobic groups into the gel surface, [42] absorbance of interfacial water combined with chemical coupling by dry gel.…”

“…[1] Recently, tissue adhesives have gained great attention as promising alternatives to surgical suture due to simple deployment, time-saving operation and avoidance of suture related complications. [2,3] Although numerous bioadhesives have been reported thus far, they are almost designed tissue, [1,41] introduction of hydrophobic groups into the gel surface, [42] absorbance of interfacial water combined with chemical coupling by dry gel. [43,44] However, as aforementioned, a Janus hydrogel with single-sided wet adhesion has been rarely reported.…”

“…When situated in a wet environment, the hydration overlayer on the substrate surface hinders intermolecular interactions between adhesive hydrogel and substrate, causing the adhesion failure. [ 37–40 ] To overcome the limitations of the hydration overlayer, several strategies have been developed to enhance wet adhesive strength of hydrogels, such as formation of chemical bond between gel surface and tissue, [ 1,41 ] introduction of hydrophobic groups into the gel surface, [ 42 ] absorbance of interfacial water combined with chemical coupling by dry gel. [ 43,44 ] However, as aforementioned, a Janus hydrogel with single‐sided wet adhesion has been rarely reported.…”

Injectable Drug Delivery System Based on In Situ Self‐Assembly of Liquid Star Polyethylene Glycol–Poly(lactic‐co‐glycolic acid)

“…For example, the viscosity of starPEG–PLGA2000 was 18 Pa s, whereas that of starPEG–PLGA6000 was around 1200 Pa s. A similar relationship between M w and viscosity values was observed for other polymers of similar composition as well. [ 18 ] Viscosity increased with the increase in molecular weight, probably due to a higher degree of entanglement between polymer chains. [ 19 ] The ability to inject the neat starPEG–PLGAs through needles in a range of gauges (G) was examined (Figure S2, Supporting Information).…”