We have carried out a theoretical investigation of hot electron power loss P , involving electronacoustic phonon interaction, as a function of twist angle θ, electron temperature Te and electron density ns in twisted bilayer graphene (tBLG). It is found that as θ decreases closer to magic angle θm, P enhances strongly and θ acts as an important tunable parameter, apart from Te and ns. In the range of Te =1-50 K, this enhancement is ∼ 250-450 times the P in monolayer graphene (MLG), which is manifestation of the great suppression of Fermi velocity vF * of electrons in moiré flat band. As θ increases away from θm, the impact of θ on P decreases, tending to that of MLG at θ ∼ 3 • . In the Bloch-Grüneisen (BG) regime, P ∼ Te 4 , ns −1/2 and vF * −2 . In the higher temperature region (∼10-50 K), P ∼ Te δ , with δ ∼ 2.0, and the behavior is still super linear in Te, unlike the phonon limited linear-in-T ( lattice temperature) resistivity ρp. P is weakly, decreasing (increasing) with increasing ns at lower (higher) Te, as found in MLG. The energy relaxation time τe is also discussed as a function of θ and Te. Expressing the power loss P = Fe(Te) − Fe(T ), in the BG regime, we have obtained a simple and useful relation Fe(T )µp(T ) = (evs 2 /2) i.e. F e(T ) = (nse 2 vs 2 /2)ρp, where µp is the acoustic phonon limited mobility and vs is the acoustic phonon velocity. The ρp estimated from this relation using our calculated Fe(T ) is nearly agreeing with the ρp of Wu et al (Phys. Rev. B 99, 165112 (2019)).