Hot and Cold Theory: Evidence in Systems Biology

Bahari, F.; Yavari, Maryam

doi:10.1007/978-3-030-80983-6_9

Cited by 1 publication

(1 citation statement)

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“…One of the main characteristics of TCM is that it considers the human body as a holistic system to achieve maximal synergistic effects and minimal side effects (Wang et al, 2012;Zhou et al, 2017;Ramsay et al, 2018). The holistic concepts proposed by the TCM theories thousands of years ago coincide with the system biology concepts in modern medicine (Bahari and Yavari, 2021). As an essential branch of system biology, network pharmacology approaches have attracted considerable attention because of their potential for understanding drug interactions in many complex diseases.…”

Section: Open Accessmentioning

confidence: 99%

A critical assessment of Traditional Chinese Medicine databases as a source for drug discovery

Wang,

Liu,

Jafari

et al. 2024

Front. Pharmacol.

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Traditional Chinese Medicine (TCM) has been used for thousands of years to treat human diseases. Recently, many databases have been devoted to studying TCM pharmacology. Most of these databases include information about the active ingredients of TCM herbs and their disease indications. These databases enable researchers to interrogate the mechanisms of action of TCM systematically. However, there is a need for comparative studies of these databases, as they are derived from various resources with different data processing methods. In this review, we provide a comprehensive analysis of the existing TCM databases. We found that the information complements each other by comparing herbs, ingredients, and herb-ingredient pairs in these databases. Therefore, data harmonization is vital to use all the available information fully. Moreover, different TCM databases may contain various annotation types for herbs or ingredients, notably for the chemical structure of ingredients, making it challenging to integrate data from them. We also highlight the latest TCM databases on symptoms or gene expressions, suggesting that using multi-omics data and advanced bioinformatics approaches may provide new insights for drug discovery in TCM. In summary, such a comparative study would help improve the understanding of data complexity that may ultimately motivate more efficient and more standardized strategies towards the digitalization of TCM.

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