Hosts and Heterologous Expression Strategies of Recombinant Toxins for Therapeutic Purposes
Luana di Leandro,
Martina Colasante,
Giuseppina Pitari
et al.
Abstract:The production of therapeutic recombinant toxins requires careful host cell selection. Bacteria, yeast, and mammalian cells are common choices, but no universal solution exists. Achieving the delicate balance in toxin production is crucial due to potential self-intoxication. Recombinant toxins from various sources find applications in antimicrobials, biotechnology, cancer drugs, and vaccines. “Toxin-based therapy” targets diseased cells using three strategies. Targeted cancer therapy, like antibody–toxin conju… Show more
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