Host-Tumor Interactions in the SJL Lymphoma Model

Abstract

A. HISTORYSpontaneous reticulum cell sarcomas (RCS) in SJL mice derived their name from the first histological description by Murphy [ 1 , 21, who categorized them using the Dunn classification [ 3 ] as Dunn Type I1 neoplasms. The primary RCS tumors appear in >90% of SJL mice at the age of approximately 13 months [I] or older and with a slightly lower incidence in males than in females [4-81. They can be transplanted in the majority of cases [4, 9; Ponzio and Thorbecke, unpublished observations], but some laboratories report a lower degree of transplantability [2, 4, 51. Around the same time as tumors arise, paraproteins also appear in serum which are predominantly of the IgGl , IgG2a and IgC2b isotype [9]. Wanebo et al. [4] did not detect paraproteins in sera of mice receiving transplants of primary tumors, but others [9] found that about 65% of transplanted primary tumors that were associated with paraproteinemia in the primary host also caused the appearance of paraproteins in recipients. In some cases these paraproteins persisted through 3-5 transplant generations [9]. Nevertheless, although plasma cells represent the predominant cell type in many of the spontaneous tumors of SJL mice (48%), it has not been established that either the plasma cells or the paraproteins represent the tumor cells or their products, respectively, rather than a response of the host. 273Int Rev Immunol Downloaded from informahealthcare.com by Freie Universitaet Berlin on 12/04/14For personal use only.

Spontaneous myopathy in the SJL/J mouse: Pathology and strength loss

“…The majority of SJL/J mice in this study developed lymphoma between 10 and 14 months of age, as has been extensively studied in this strain (reviewed in Ref. 19). Muscle disease parameters were correlated with the development of lymphoma and extent of tumor burden in 14-month-old SJL/J mice (Table 1).…”

“…In this report we will describe the natural history, pathology and ''clinical'' effects on mouse strength of this spontaneous myopathy in SJL/J mice aged 2-16 months. Because the majority of SJL/J mice spontaneously develop B-cell lymphomas around 1 year of age, 19 we will discuss the relationship between spontaneous myopathy and lymphoma.…”

Mutagenesis associated with nitric oxide production in transgenic SJL mice

“…When injected into immunologically compatible mice, RcsX cells localize to the spleen and lymphatic tissues of the host (22)(23)(24). In these target tissues, the superantigen presented on the surface of the RcsX cells induces a potent inflammatory response by stimulating V␤16 ϩ T cells (12).…”

Dependence of Lymphoma Growth on ‘Reversed Immunological Surveillance’

“…The RCS of SJL mice have been the subject of recent review articles [3,4] and readers are referred to these sources for additional information on this tumor model. In this article, we wish to present both an overview of the model sys tem and the results of some of our current investigations, involving immunotherapy of RCS-injected mice, based on the data re ferred to above, which suggests a require ment of the host immune system for optimal tumor growth in vivo.…”