volume 13, issue 12, Pe1006800 2017
DOI: 10.1371/journal.ppat.1006800
View full text
|
Sign up to set email alerts
|
Share

Abstract: Intracellular infection and multi-organ colonization by the protozoan parasite, Trypanosoma cruzi, underlie the complex etiology of human Chagas disease. While T. cruzi can establish cytosolic residence in a broad range of mammalian cell types, the molecular mechanisms governing this process remain poorly understood. Despite the anticipated capacity for fatty acid synthesis in this parasite, recent observations suggest that intracellular T. cruzi amastigotes may rely on host fatty acid metabolism to support in…

Expand abstract