Host susceptibility genes of asymptomatic malaria from South Central Timor, Eastern Indonesia

Fitri, Nyoman; Na‐Bangchang, Kesara; Tjitra, Emiliana; Hutagalung, Jontari; Sunarno, Sunarno; Dewi, Rita Marleta; Handayani, Sarwo; Chai่jaroenkul, Wanna

doi:10.1007/s00436-022-07696-0

Parasitol Res

2022

DOI: 10.1007/s00436-022-07696-0

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Host susceptibility genes of asymptomatic malaria from South Central Timor, Eastern Indonesia

Nyoman Fitri

Kesara Na‐Bangchang²,

Emiliana Tjitra³

et al.

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2023

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Profiles of global mutations in the human intercellular adhesion molecule-1 (ICAM-1) shed light on population-specific malaria susceptibility

Gill,

Singh,

Sharma

2023

BMC Genomics

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Plasmodium falciparum is responsible for malaria-related morbidity and mortality. PfEMP1 (P. falciparum erythrocyte membrane protein 1) mediates infected erythrocytes adhesion to various surface vascular receptors, including intercellular adhesion molecule-1 (ICAM-1), associating this interaction with severe malaria in several studies. Genetic variation in host ICAM-1 plays a significant role in determining susceptibility to malaria infection via clinical phenotypes such as the ICAM-1Kilifi variant which has been reported to be associated with susceptibility in populations. Our genomic and structural analysis of single nucleotide polymorphisms (SNPs) in ICAM-1 revealed 9 unique mutations each in its distinct A-type and BC-type PfEMP1 DBLβ-interacting regions. These mutations are noted in only a few field isolates and mainly in the African/African American population. The ICAM-1Kilifi variant lies in a flexible loop proximal to the DBLβ-interacting region. This analysis will assist in establishing functional correlations of reported global mutations via experimental and clinical studies and in the tailored design of population-specific genetic surveillance studies. Understanding host polymorphism as an evolutionary force in diverse populations can help to predict predisposition to disease severity and will contribute towards laying the framework for designing population-specific personalized medicines for severe malaria.

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Profiles of global mutations in the human intercellular adhesion molecule-1 (ICAM-1) shed light on population-specific malaria susceptibility

Gill,

Singh,

Sharma

2023

BMC Genomics

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show abstract

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Host susceptibility genes of asymptomatic malaria from South Central Timor, Eastern Indonesia

Cited by 1 publication

References 60 publications

Profiles of global mutations in the human intercellular adhesion molecule-1 (ICAM-1) shed light on population-specific malaria susceptibility

Profiles of global mutations in the human intercellular adhesion molecule-1 (ICAM-1) shed light on population-specific malaria susceptibility

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