Host Resistance to Malaria

Brown, K. N.

doi:10.1007/978-1-4613-3424-8_6

Cited by 3 publications

(1 citation statement)

References 88 publications

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“…In terms of the pathophysiology of lung disease, the CF-specific CDS may serve to counterbalance or block the action of some of the chemoattractants produced in carriers, thus preventing excessive infiltration of PMN (with subsequent tissue damage by lysosomal enzymes released from PMN and other related problems) as is observed in the lungs of CF patients (1). Thus, the CF-specific CDS in the heterozygote may produce a selective biological advantage (protection against obstructive pulmonary disease) analogous to that of carriers of the sickle cell trait (protection against malaria due to the presence of high levels of fetal hemoglobin [27]); this could explain why the CF gene has been maintained at such a high frequency in the Caucasian population. On the other hand, too much CF-specific CDS could be detrimental (i.e., in CF homozygotes).…”

Section: Discussionmentioning

confidence: 99%

Cystic fibrosis ciliary dyskinesia substances and pulmonary disease. Effects of ciliary dyskinesia substances on neutrophil movement in vitro.

Wilson¹,

Fudenberg²,

Parise³

et al. 1981

J. Clin. Invest.

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A B S T R A C T Cultured mononuclear cells (MNC) from individuals homozygous or heterozygous for the defective gene causing the inherited disease cystic fibrosis (CF) synthesize three unusual "mediators" termed ciliary dyskinesia substances (CDS), which markedly affect tracheal mucociliary systems in vitro. MNC cultures from normal healthy controls do not accumulate any CDS, whereas MNC cultures from non-CF patient controls with pulmonary disease synthesize at least one CDS. The possible involvement of the CDS in pulmonary disease is being investigated. In this study, we sought to determine whether the CDS could be chemoattractants for polymorphonuclear neutrophils (PMN), since they have characteristics in common with known chemoattractants generated by alveolar macrophages. Our

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Section: Discussionmentioning

confidence: 99%

Cystic fibrosis ciliary dyskinesia substances and pulmonary disease. Effects of ciliary dyskinesia substances on neutrophil movement in vitro.

Wilson¹,

Fudenberg²,

Parise³

et al. 1981

J. Clin. Invest.

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Maturation of the Intracellular Parasite and Antigenicity

Brown¹,

Boyle²,

Newbold³

1983

Ciba Foundation Symposium 94 ‐ Malaria and the Red Cell

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Protective immunity to malaria. Studies with cloned lines of Plasmodium chabaudi chabaudi and P. berghei in CBA/Ca mice. II. The effectiveness and inter‐ or intra‐species specificity of the passive transfer of immunity with serum

Jarra¹,

Hills²,

March³

et al. 1986

Parasite Immunology

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Serum was obtained from CBA/Ca mice infected, reinfected or superinfected with parasites taken one or two syringe passages from cryopreserved reference stabilates derived from cloned lines of the AS or CB isolates of P.c. chabaudi. Serum was also collected from mice superinfected with parasites derived from a cloned line of P. berghei KSP-11. When injected into normal syngeneic recipients subsequently challenged with homologous or heterologous parasites, these sera mediated some or all of the following modifications to the breakthrough parasitaemias which invariably occurred (i) an extension of the pre-patent period (ii) an extension of the time taken for the parasitaemia to reach 2% (iii) a reduction of peak parasitaemia (iv) protraction of the initial peak of parasitaemia. These modifications were particularly evident with serum from superinfected mice and to a lesser extent with serum from animals reinfected once after recovery from a primary infection. Serum taken during the course of such a primary infection produced extended pre-2% periods, other effects being only marginal. Serum mediated modifications produced by reinfection and superinfection serum appeared largely species-specific with a limited degree of cross-reactivity. Intraspecific specificity was also apparent with serum from P.c. chabaudi AS or CB reinfected or superinfected mice, although marginal cross-immunity was again observed. When analysed by the fluorescent antibody technique on smears of methanol fixed parasitized erythrocytes, reinfection and superinfection sera were almost totally cross-reactive both within and across species. Preliminary evidence that parasites breaking through the effects of these sera may constitute a phenotypic antigenic variant is presented and possible mechanisms for the parasitaemia modifying effects of the various sera discussed.

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Host Resistance to Malaria

Cited by 3 publications

References 88 publications

Cystic fibrosis ciliary dyskinesia substances and pulmonary disease. Effects of ciliary dyskinesia substances on neutrophil movement in vitro.

Cystic fibrosis ciliary dyskinesia substances and pulmonary disease. Effects of ciliary dyskinesia substances on neutrophil movement in vitro.

Maturation of the Intracellular Parasite and Antigenicity

Protective immunity to malaria. Studies with cloned lines of Plasmodium chabaudi chabaudi and P. berghei in CBA/Ca mice. II. The effectiveness and inter‐ or intra‐species specificity of the passive transfer of immunity with serum

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