Host Range and Genetic Diversity of Arenaviruses in Rodents, United Kingdom

Blasdell, Kim R.; Becker, S.; Hurst, Jane L.; Begon, Michael; Bennett, Malcolm J.

doi:10.3201/eid1409.080209

Cited by 22 publications

(18 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Those results are consistent with the genetic heterogeneity seen in other arenaviruses [83]. Comparison of nucleic acid and protein sequences within specific arenaviruses showed identities ranging from 90–95% [84], even if they were isolated in the same region [85,86]; and viruses isolated from different regions ranged from 78 to 86% [85,86]. Sequence comparison of all proteins of seven pathogenic arenaviruses showed identities ranging from 44 to 63% [84].…”

Section: Arenavirus Plasticitysupporting

confidence: 69%

“…The genetic diversity within and between isolated arenavirus groups, suggests that the spatial heterogeneity may be reflected in host range and pathogenicity. Consequently, sequence analysis of new virus isolates could be useful for tracking the source of arenaviruses outbreaks [86]. …”

Section: Arenavirus Plasticitymentioning

confidence: 99%

“…Some of them are refractory to disease [14,86,137,138,139,140,141,142,143,144]. Arenaviruses co-evolved with their natural host but little is known about those processes in other animals and the implication for pathogenesis.…”

Section: Arenavirus Plasticitymentioning

confidence: 99%

See 2 more Smart Citations

Arenavirus Variations Due to Host-Specific Adaptation

Zapata

Salvato

2013

Viruses

View full text Add to dashboard Cite

Arenavirus particles are enveloped and contain two single-strand RNA genomic segments with ambisense coding. Genetic plasticity of the arenaviruses comes from transcription errors, segment reassortment, and permissive genomic packaging, and results in their remarkable ability, as a group, to infect a wide variety of hosts. In this review, we discuss some in vitro studies of virus genetic and phenotypic variation after exposure to selective pressures such as high viral dose, mutagens and antivirals. Additionally, we discuss the variation in vivo of selected isolates of Old World arenaviruses, particularly after infection of different animal species. We also discuss the recent emergence of new arenaviruses in the context of our observations of sequence variations that appear to be host-specific.

show abstract

Section: Arenavirus Plasticitysupporting

confidence: 69%

Section: Arenavirus Plasticitymentioning

confidence: 99%

See 1 more Smart Citation

Arenavirus Variations Due to Host-Specific Adaptation

Zapata

Salvato

2013

Viruses

View full text Add to dashboard Cite

show abstract

“…LCMV was thought to be the only arenavirus in Europe and to reside primarily in the house mouse (Mus musculus) (Blasdell et al 2008). However, high seroprevalence in other mice and vole species (including field voles) , Blasdell et al 2008, Tagliapietra et al 2009), and the identification of an independent genetic lineage in wood mice (Ledesma et al 2009), has led to the suggestion of spillover and/or the circulation of multiple related and cross-reactive arenaviruses.…”

Section: Introductionmentioning

confidence: 99%

Food resources and intestinal parasites as limiting factors for boreal vole populations during winter

Forbes

Stuart

Mappes

et al. 2014

Ecology

View full text Add to dashboard Cite

Processes limiting the growth of cyclic vole populations have stimulated considerable research and debate over several decades. In Fennoscandia, the peak density of cyclic vole populations occurs in fall, and is followed by a severe winter decline. Food availability and intestinal parasites have been demonstrated to independently and synergistically limit wildlife populations. The purpose of this study was to directly compare competing food and parasite hypotheses on the limitation of overwintering high‐density vole populations. Moreover, we evaluated the ability of food limitation and nematode infection to interact and thereby intensify population declines. A two‐factor experiment with food supplementation and antihelminthic medication was conducted on replicated, enclosed field vole (Microtus agrestis) populations in central Finland over one full boreal winter. Population abundance, survival, and demographic attributes were monitored through live trapping. Vole feces were concurrently examined for the eggs of Heligmosomidae nemadotes and oocysts of eimerian coccidians. We found that vole density declined in all treatment groups throughout winter. However, food supplementation mitigated this decline through positive effects on reproduction, and voles in food‐supplemented populations were generally in better physiological condition than non‐supplemented voles. Food supplementation and antihelminthic treatment reduced the prevalence of Heligmosomidae nematodes, while neither food nor medication affected the prevalence of eimerians, or infection intensity of either parasite group. Although food supplementation and antihelminthic medication aided in the clearance of Heligmosomidae nematodes, their prevalence did not influence vole population growth, and this parasite group is therefore unlikely to contribute to the cyclic winter decline of boreal vole populations. Instead food resources acting alone were the primary factor limiting vole population growth.

show abstract

“…However, high seroprevalence in other mice and vole species (including field voles) , Blasdell et al 2008, Tagliapietra et al 2009), and the identification of an independent genetic lineage in wood mice (Ledesma et al 2009), has led to the suggestion of spillover and/or the circulation of multiple related and cross-reactive arenaviruses.…”

Section: Introductionmentioning

confidence: 99%

Serological Survey of Rodent-Borne Viruses in Finnish Field Voles

Forbes

Voutilainen

Jääskeläinen

et al. 2014

Vector-Borne and Zoonotic Diseases

View full text Add to dashboard Cite

In northern Europe, rodent populations display cyclic density fluctuations that can be correlated with the human incidence of zoonotic diseases they spread. During density peaks, field voles (Microtus agrestis) become one of the most abundant rodent species in northern Europe, yet little is known of the viruses they host. We screened 709 field voles, trapped from 14 sites over 3 years, for antibodies against four rodent-borne, potentially zoonotic viruses or virus groups-hantaviruses, lymphocytic choriomeningitis virus (LCMV), Ljungan virus (LV), and orthopoxviruses (OPV). Antibodies against all four viruses were detected. However, seroprevalence of hantaviruses, LV, and LCMV was low. OPV antibodies (most likely cowpox) were more common but restricted geographically to southeastern Finland. Within these sites, antibody prevalence showed delayed density dependence in spring and direct density dependence in fall. Higher seroprevalence was found in spring than fall. These results substantially increase knowledge of the presence and distribution of viruses of field voles in Finland, as well as CPXV infection dynamics.

show abstract

Host Range and Genetic Diversity of Arenaviruses in Rodents, United Kingdom

Cited by 22 publications

References 13 publications

Arenavirus Variations Due to Host-Specific Adaptation

Arenavirus Variations Due to Host-Specific Adaptation

Food resources and intestinal parasites as limiting factors for boreal vole populations during winter

Serological Survey of Rodent-Borne Viruses in Finnish Field Voles

Contact Info

Product

Resources

About