Abstract:Wolbachia bacteria are among the most successful endosymbionts in nature, carried by half of all insect species. Unlike human bacterial pathogens that kill host cells and tissues, Wolbachia endosymbionts are generally carried by insects with little adverse effect. The striking difference in outcome raises a basic question of what aspects of infection mechanisms are conserved across systems. In this study, 37 small molecule inhibitors were used to test whether 14 candidate host processes that affect the abundan… Show more
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