Host-Parasite Relationship in Cystic Echinococcosis: An Evolving Story

Siracusano, Alessandra; Delunardo, Federica; Teggi, Antonella; Ortona, Elena

doi:10.1155/2012/639362

Cited by 118 publications

(106 citation statements)

References 99 publications

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, the chemical composition of cyst fluid was discussed in some detail (Neisser, 1877). Recent developments of the immunobiology of the Echinococcus infection are described in previous reviews (e.g., Heath, 1995;Lightowlers and Gottstein, 1995;Gottstein and Hemphill, 2008;Mejri et al, 2010;Siracusano et al, 2012;Zhang et al, 2012) and in Chapter "Immunology...".…”

Section: Echinococcosis In Humansmentioning

confidence: 99%

Historical Aspects of Echinococcosis

Eckert

Thompson

2017

Echinococcus and Echinococcosis, Part A

View full text Add to dashboard Cite

Section: Echinococcosis In Humansmentioning

confidence: 99%

Historical Aspects of Echinococcosis

Eckert

Thompson

2017

Echinococcus and Echinococcosis, Part A

View full text Add to dashboard Cite

“…Cystic echinococcosis (CE), a chronic helminthic disease that is caused by infection with metacestodes of the tapeworm Echinococcus granulosus, is one of the most widespread zoonotic diseases in humans in developing and developed countries (1). CE is prevalent in temperate zone countries, including South America, the entire Mediterranean region, Russia, central Asia, China and parts of Africa (2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

Role of soluble programmed death-1 (sPD-1) and sPD-ligand 1 in patients with cystic echinococcosis

Lǐ

Xiao

et al. 2015

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. The programmed death-1 (PD-1)/PD-ligand 1 (PD-L1) signaling pathway is a negative regulatory mechanism that inhibits T cell proliferation and cytokine production. Soluble PD-1 (sPD-1) and soluble PD-L1 (sPD-L1), are also involved in regulation of the PD-1/PD-L1 signaling pathway. In the present study, the expression levels of sPD-1 and sPD-L1, as well as those of T helper (Th)1 [including interleukin (IL)-2 and interferon gamma], Th2 (including IL-4, IL-6 and IL-10) and Th17 (including interleukin 17) cell cytokines, were measured in the sera of patients with cystic echinococcosis (CE). Measurements were performed prior to and following after surgery and treatment with cyclic albendazole to investigate the effects of sPD-1 and sPD-L1 in patients with CE. Cytokine expression levels were measured using cytokine bead array and the expression levels of sPD-1 and sPD-L1 were measured using ELISA. In addition, in vitro stimulation was used to detect whether sPD-L1 has a negative regulatory effect on cytokine secretion or homeostasis. The present study observed significantly higher levels of sPD-L1 in patients with CE compared with healthy controls. Significantly elevated levels of Th2 cytokines in the sera of patients with CE were also observed. The results also suggest that there is an imbalanced expression of Th1 and Th2 cells during CE. In addition, it was demonstrated that sPD-1 and sPD-L1 are regulatory factors to the PD-1/PD-L1 signaling pathway, each having opposite effect, suggesting that they regulate the immune response to CE infection by creating a dynamic balance. In conclusion, sPD-L1 may play an important role in maintaining homeostasis in hosts with CE.

show abstract

“…It causes 1 million disability-adjusted life years in humans and an annual loss of 2 billion US dollars in livestock (Budke et al, 2006). Recently, the World Health Organization has included CE as part of a neglected zoonosis subgroup for its strategic plans for the control of neglected tropical diseases (Siracusano et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Molecular identification of Echinococcus granulosus on the Tibetan Plateau using mitochondrial DNA markers

Hu¹,

Song²,

Wang³

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Cystic echinococcosis (CE) is an important worldwide zoonotic disease that causes large economic losses and human suffering. Echinococcus granulosus, the causative agent of CE, exhibits different genotypes in different locations. In order to identify its genotypes and analyze its genetic structure on the Tibetan Plateau, we collected 72 hydatid cysts from different intermediate hosts and amplified and sequenced their mitochondrial cytochrome c oxidase subunit 2 (cox2) genes. Seventy isolates were identified as the E. granulosus G1 genotype, while two isolates belonged to the G6 genotype. There were 18 haplotypes among the 70 E. granulosus isolates, which exhibited a star-like network pattern and shared a common haplotype (H 1 ). There was little difference between geographical sub-populations. Our results suggest that a recent E. granulosus population expansion occurred 13915-13923 (2015) on the Tibetan Plateau, suggesting that E. granulosus was introduced into China. This study increases the basic molecular data needed for the molecular diagnosis, epidemiology, prevention, and control of Echinococcus diseases.

show abstract

Host-Parasite Relationship in Cystic Echinococcosis: An Evolving Story

Cited by 118 publications

References 99 publications

Historical Aspects of Echinococcosis

Historical Aspects of Echinococcosis

Role of soluble programmed death-1 (sPD-1) and sPD-ligand 1 in patients with cystic echinococcosis

Molecular identification of Echinococcus granulosus on the Tibetan Plateau using mitochondrial DNA markers

Contact Info

Product

Resources

About