Host Origin of Marrow Mesenchymal Stem Cells Following Allogeneic Cord-Blood Stem-Cell Transplantation

Hongeng, Suradej; Petvises, Sawang; Rerkamnuaychoke, Budsaba; Worapongpaiboon, Surapon; Tardtong, P; Apibal, S; Ungkanont, Artit

doi:10.1007/bf02982012

Cited by 6 publications

(2 citation statements)

References 4 publications

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“…IL‐6 and CNTF share a common receptor component, the glycoprotein 130 receptor complex (Hongeng et al, ), that activates the Janus‐activated kinase‐signal transducer activator of transcription (JAK‐STAT) and mitogen‐activated protein kinase (MAPK) signal transduction pathways (Bauer et al, ). In addition, IL‐6 acts directly on neurite regeneration and up‐regulation of the mRNA level of CNTF in rat dorsal ganglion culture (Shuto et al, ).…”

Section: Discussionmentioning

confidence: 99%

Intraperitoneal administration of adipose tissue‐derived stem cells for the rescue of retinal degeneration in a mouse model via indigenous CNTF up‐regulation by IL‐6

Heo

Yoon²,

Ahn

et al. 2017

J Tissue Eng Regen Med

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As the world's population begins to age, retinal degeneration is an increasing problem, and various treatment modalities are being developed. However, there have been no therapies for degenerative retinal conditions that are not characterized by neovascularization. We investigated whether transplantation of mouse adipose tissue-derived stem cells (mADSC) into the intraperitoneal space has a rescue effect on NaIO -induced retinal degeneration in mice. In this study, mADSC transplantation recovered visual function and preserved the retinal outer layer structure compared to the control group without any integration of mADSC into the retina. Moreover, endogenous ciliary neurotrophic factor (CNTF) was elevated in the retinas of mADSC-treated mice. We found that lipopolysaccharide (LPS) or LPS-stimulated monocyte supernatant induced the secretion of granulocyte colony stimulating factor (GCSF), CD54, CXCL10, interleukin-6 (IL-6), and CCL5 from the mADSC by cytokine array. Network inference was conducted to investigate signaling networks related to CNTF regulation. Based on bioinformatics data, the expression of IL-6 was related to the expression of CNTF. Additionally, intravitreal injection of IL-6 in rats produced up-regulation of endogenous CNTF in the retina. mADSC had a rescue effect on retinal degeneration through the up-regulation of endogenous CNTF by IL-6. Thus, transplantation of mADSC could be a potential treatment option for retinal degeneration.

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Section: Discussionmentioning

confidence: 99%

Intraperitoneal administration of adipose tissue‐derived stem cells for the rescue of retinal degeneration in a mouse model via indigenous CNTF up‐regulation by IL‐6

Heo

Yoon²,

Ahn

et al. 2017

J Tissue Eng Regen Med

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“…However, numerous studies of bone marrow (BM) chimeras demonstrate that BM stromal cells, including mesenchymal stem cells (MSCs), are host derived after BM transplantation. 1,[4][5][6][7][8][9][10] Multipotent adult progenitor cells (MAPCs) are stem cells obtained from BM that can differentiate into mesodermal (eg, osteoblast, chondrocytes, adipocytes, myoblasts, and endothelial cells), endodermal (eg, hepatocytes), and ectodermal (eg, neurons, oligodendrocytes, and astrocytes) cells. [11][12][13][14][15] MAPCs are isolated within the BM adherent cell component, but their origin is still unknown.…”

Section: Introductionmentioning

confidence: 99%

Donor origin of multipotent adult progenitor cells in radiation chimeras

Reyes

Foraker

et al. 2005

Blood

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Mesenchymal stem cells obtained after bone marrow transplantation or peripheral blood stem cell transplantation originate from host tissue

et al. 2005

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Mesenchymal stem cells (MSC) obtained from human bone marrow have been described as adult stem cells with the ability of extensive self-renewal and clonal expansion, as well as the capacity to differentiate into various tissue types and to modulate the immune system. Some data indicate that leukapheresis products may also contain non-hematopoietic stem cells, as they occur in whole bone marrow transplantation (BMT). However, there is still controversy whether MSC expand in the host after transplantation like blood progenitor cells do. Therefore, we were interested in finding out if graft MSC can be detected in leukapheresis products and in bone marrow after BMT and peripheral blood stem cell transplantation (PBSCT). Every sample from total bone marrow transplants exhibited growth of MSC after in vitro culture, but not one of nine leukapheresis products did. In addition, bone marrow aspirates of 9 patients receiving BMT and of 18 patients after PBSCT were examined for origin of MSC. Almost all MSC samples exhibited a complete host profile, whereas peripheral blood cells were of donor origin. We conclude that even if trace amounts of MSC are co-transplanted during PBSCT or BMT, they do not expand significantly in the host bone marrow.

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Host Origin of Marrow Mesenchymal Stem Cells Following Allogeneic Cord-Blood Stem-Cell Transplantation

Cited by 6 publications

References 4 publications

Intraperitoneal administration of adipose tissue‐derived stem cells for the rescue of retinal degeneration in a mouse model via indigenous CNTF up‐regulation by IL‐6

Intraperitoneal administration of adipose tissue‐derived stem cells for the rescue of retinal degeneration in a mouse model via indigenous CNTF up‐regulation by IL‐6

Donor origin of multipotent adult progenitor cells in radiation chimeras

Mesenchymal stem cells obtained after bone marrow transplantation or peripheral blood stem cell transplantation originate from host tissue

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