Host-microbe interactions in chronic rhinosinusitis biofilms and models for investigation

Vanderpool, Emily J.; Rumbaugh, Kendra P.

doi:10.1016/j.bioflm.2023.100160

Cited by 3 publications

(3 citation statements)

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“…A wide diversity of animals and procedures have been used to characterize different biofilm-associated infections in vivo, which complicates the translation of those results in the clinical context. However, there are some well-established models for certain infections such as chronic otitis media (Chaney et al, 2011), chronic wounds (Gurjala et al, 2011), chronic rhinosinusitis (Vanderpool & Rumbaugh, 2023) and osteomyelitis (Funao et al, 2012), among others (Anju et al, 2022;Guzm an-Soto et al, 2021).…”

Section: Biofilm Detection and Study: In Vitro And In Vivo Modelsmentioning

confidence: 99%

Nanomedicine against biofilm infections: A roadmap of challenges and limitations

Blanco‐Cabra,

Alcàcer‐Almansa,

Admella

et al. 2024

WIREs Nanomed Nanobiotechnol

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Microbial biofilms are complex three‐dimensional structures where sessile microbes are embedded in a polymeric extracellular matrix. Their resistance toward the host immune system as well as to a diverse range of antimicrobial treatments poses a serious health and development threat, being in the top 10 global public health threats declared by the World Health Organization. In an effort to combat biofilm‐related microbial infections, several strategies have been developed to independently eliminate biofilms or to complement conventional antibiotic therapies. However, their limitations leave room for other treatment alternatives, where the application of nanotechnology to biofilm eradication has gained significant relevance in recent years. Their small size, penetration efficiency, and the design flexibility that they present makes them a promising alternative for biofilm infection treatment, although they also present set‐backs. This review aims to describe the main possibilities and limitations of nanomedicine against biofilms, while covering the main aspects of biofilm formation and study, and the current therapies for biofilm treatment.This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials Toxicology and Regulatory Issues in Nanomedicine > Regulatory and Policy Issues in Nanomedicine

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Section: Biofilm Detection and Study: In Vitro And In Vivo Modelsmentioning

confidence: 99%

Nanomedicine against biofilm infections: A roadmap of challenges and limitations

Blanco‐Cabra,

Alcàcer‐Almansa,

Admella

et al. 2024

WIREs Nanomed Nanobiotechnol

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“…Host-microbe interactions are pivotal in shaping human health and disease across various conditions, ranging from chronic illnesses such as rhinosinusitis to prevalent pediatric ailments like otitis media (OM). These interactions entail a complex interplay between microorganisms and the human host, influencing disease pathogenesis and treatment outcomes [ 8 , 9 ]. Understanding these intricate dynamics is paramount for unraveling the underlying mechanisms of diseases and devising effective therapeutic interventions.…”

Section: Reviewmentioning

confidence: 99%

“…For instance, investigations have elucidated how microbial communities influence the colonization of pathogens in conditions such as OM, where specific bacteria contribute to disease susceptibility [ 8 ]. Similarly, biofilms observed in CRS serve as a valuable model for studying microbe-microbe and host-microbe interactions, providing insights into the altered physiological conditions associated with these disorders [ 9 ]. The field of host-microbe interactions encompasses diverse research areas, including genetics, microbiome studies, and the development of novel antimicrobial agents.…”

Section: Reviewmentioning

confidence: 99%

A Comprehensive Review on Biofilms in Otorhinolaryngology: Understanding the Pathogenesis, Diagnosis, and Treatment Strategies

Ghosh Moulic,

Deshmukh,

Gaurkar

2024

Cureus

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Biofilms, structured communities of microorganisms encased in a self-produced matrix, pose significant challenges in otorhinolaryngology due to their role in chronic and recurrent infections affecting the ear, nose, and throat (ENT) region. This review provides an overview of biofilms, emphasizing their formation, pathogenesis, diagnosis, and treatment strategies in otorhinolaryngological disorders. Biofilms are pivotal in chronic rhinosinusitis (CRS), otitis media, laryngopharyngeal reflux (LPR), and tonsillitis, contributing to treatment resistance and disease recurrence. Current diagnostic techniques, including imaging modalities, microbiological cultures, and molecular techniques, are discussed, alongside emerging technologies. Treatment strategies, ranging from conventional antibiotics to alternative therapies, such as biofilm disruptors, phage therapy, and immunomodulation, are evaluated in terms of their efficacy and potential clinical applications. The review underscores the significance of understanding biofilms in otorhinolaryngology and highlights the need for tailored approaches to diagnosis and management to improve patient outcomes.

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Towards improved biofilm models

Rumbaugh,

Whiteley

2024

Nat Rev Microbiol

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Host-microbe interactions in chronic rhinosinusitis biofilms and models for investigation

Cited by 3 publications

References 200 publications

Nanomedicine against biofilm infections: A roadmap of challenges and limitations

Nanomedicine against biofilm infections: A roadmap of challenges and limitations

A Comprehensive Review on Biofilms in Otorhinolaryngology: Understanding the Pathogenesis, Diagnosis, and Treatment Strategies

Towards improved biofilm models

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