Host Markers and Prognosis in Recurrent Rectal Carcinomas Treated with Radiotherapy

Hannisdal, Einar; Theodorsen, L.; Høst, Herman

doi:10.3109/02841869409098438

Cited by 9 publications

(19 citation statements)

References 31 publications

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“…Only two [ 57 , 58 ] were negative. In another ten studies [ 26 , 59 – 66 ] CRP predicted prognosis by univariate analysis only; one of these was underpowered ( Table 2 , Fig 2 ). Elevated CRP independently predicted prognosis in thirty five of the 42 (71%) studies in gastroesophageal cancer.…”

Section: Resultsmentioning

confidence: 99%

C-Reactive Protein Is an Important Biomarker for Prognosis Tumor Recurrence and Treatment Response in Adult Solid Tumors: A Systematic Review

et al. 2015

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PurposeA systematic literature review was done to determine the relationship between elevated CRP and prognosis in people with solid tumors. C-reactive protein (CRP) is a serum acute phase reactant and a well-established inflammatory marker. We also examined the role of CRP to predict treatment response and tumor recurrence.MethodsMeSH (Medical Subject Heading) terms were used to search multiple electronic databases (PubMed, EMBASE, Web of Science, SCOPUS, EBM-Cochrane). Two independent reviewers selected research papers. We also included a quality Assessment (QA) score. Reports with QA scores <50% were excluded. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) methodology was utilized for this review (S1 PRISMA Checklist).Results271 articles were identified for final review. There were 45% prospective studies and 52% retrospective. 264 had intermediate QA score (≥50% but <80%); Seven were adequate (80% -100%); A high CRP was predictive of prognosis in 90% (245/271) of studies—80% of the 245 studies by multivariate analysis, 20% by univariate analysis. Many (52%) of the articles were about gastrointestinal malignancies (GI) or kidney malignancies. A high CRP was prognostic in 90% (127 of 141) of the reports in those groups of tumors. CRP was also prognostic in most reports in other solid tumors primary sites.ConclusionsA high CRP was associated with higher mortality in 90% of reports in people with solid tumors primary sites. This was particularly notable in GI malignancies and kidney malignancies. In other solid tumors (lung, pancreas, hepatocellular cancer, and bladder) an elevated CRP also predicted prognosis. In addition there is also evidence to support the use of CRP to help decide treatment response and identify tumor recurrence. Better designed large scale studies should be conducted to examine these issues more comprehensively.

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Section: Resultsmentioning

confidence: 99%

C-Reactive Protein Is an Important Biomarker for Prognosis Tumor Recurrence and Treatment Response in Adult Solid Tumors: A Systematic Review

et al. 2015

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“…Haptoglobin (P00738) has been associated with the implantation and angiogenesis of the carcinoma, and several authors have stated that haptoglobin is increased in CRC [28][29][30]. In fact, haptoglobin had been connected to CRC as a serum tumour marker, even together with carcinoembryonic antigen [28,29], and it was also described as a prognostic tumour marker for CRC [30]. The inter-alpha-trypsin inhibitor heavy chain H4 (Q14624) was shown to be involved in malignant transformation of lung tissue [31].…”

Section: Resultsmentioning

confidence: 99%

Concanavalin A chromatography coupled to two-dimensional gel electrophoresis improves protein expression studies of the serum proteome

Rodríguez-Piñeiro

Ayude

Rodrı́guez-Berrocal

et al. 2004

Journal of Chromatography B

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“…The association between increased ESR and malignant diseases is not understood, but several theories exist. Hannisdal et al (13) perceived ESR as a typical host marker, defined as a measurable parameter representing the body's reaction to the invading neoplasm in contrast to substances produced by the neoplasm. Furthermore, Johansson et al (9) found ESR to be of interest in tumor biology and the tumor-host relationship.…”

Section: Discussionmentioning

confidence: 99%

“…It is influenced by fluctuations in both acute-phase plasma proteins and hematocrit. It has been shown to be a powerful predictor of survival in human prostate carcinoma (8, 9), as well as in several other human cancers (10)(11)(12)(13)(14). It is well known that ESR is influenced by erythrocyte count, serum protein concentration, fibrinogen, a,globulin.…”

Section: Discussionmentioning

confidence: 99%

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Erythrocyte Sedimentation Rate—A Predictor of Malignant Potential in Early Prostate Cancer

1997

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Host Markers and Prognosis in Recurrent Rectal Carcinomas Treated with Radiotherapy

Cited by 9 publications

References 31 publications

C-Reactive Protein Is an Important Biomarker for Prognosis Tumor Recurrence and Treatment Response in Adult Solid Tumors: A Systematic Review

C-Reactive Protein Is an Important Biomarker for Prognosis Tumor Recurrence and Treatment Response in Adult Solid Tumors: A Systematic Review

Concanavalin A chromatography coupled to two-dimensional gel electrophoresis improves protein expression studies of the serum proteome

Erythrocyte Sedimentation Rate—A Predictor of Malignant Potential in Early Prostate Cancer

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