Host macrocyclic acylcarnitines mediate symbiotic interactions between frogs and their skin microbiome

Brunetti, Andrés E.; Lyra, Mariana L.; Bauermeister, Anelize; Bunk, Boyke; Boedeker, Christian; Müsken, Mathias; Neto, Fausto Carnevale; Mendonça, Jacqueline Nakau; Caraballo-Rodríguez, Andrés Mauricio; Melo, Weilan G.P.; Pupo, Mônica T.; Haddad, Célio F.B.; Cabrera, Gabriela M.; Overmann, Jörg; Lopes, Norberto P.

doi:10.1016/j.isci.2023.108109

Cited by 3 publications

(2 citation statements)

References 64 publications

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“…However, amphibian populations worldwide are declining mainly due to multiple environmental and anthropogenic stressors such as habitat fragmentation, environmental pollution, invasive alien species, climate change impacts, and the emergence of pathogenic fungi. − Significantly, and in contrast to the case of other extant terrestrial clades (i.e., squamates, birds, and mammals), amphibians’ skin is highly dynamic, contributing to essential functions such as respiration and the body’s osmotic balance . In addition, it is considered a natural laboratory of organic chemistry because of the enormous diversity of compounds produced by the dermal glands, which act against predators but also are essential elements of the innate immune system against pathogens ,, and as regulatory mechanisms of the microbiome. , …”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Review of Patented Antimicrobial Peptides from Amphibian Anurans

García,

Fuentes,

Alonso

et al. 2024

J. Nat. Prod.

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Since the 1980s, studies of antimicrobial peptides (AMPs) derived from anuran skin secretions have unveiled remarkable structural diversity and a wide range of activities. This study explores the potential of these peptides for drug development by examining granted patents, amino acid modifications related to patented peptides, and recent amphibians' taxonomic updates influencing AMP names. A total of 188 granted patents related to different anuran peptides were found, with Asia and North America being the predominant regions, contributing 65.4% and 15.4%, respectively. Conversely, although the Neotropical region is the world's most diversified region for amphibians, it holds only 3.7% of the identified patents. The antimicrobial activities of the peptides are claimed in 118 of these 188 patents. Additionally, for 160 of these peptides, 66 patents were registered for the natural sequence, 69 for both natural and derivative sequences, and 20 exclusively for sequence derivatives. Notably, common modifications include alterations in the side chains of amino acids and modifications to the peptides' N-and C-termini. This review underscores the biomedical potential of anuran-derived AMPs, emphasizing the need to bridge the gap between AMP description and practical drug development while highlighting the urgency of biodiversity conservation to facilitate biomedical discoveries.

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Section: Introductionmentioning

confidence: 99%

A Comprehensive Review of Patented Antimicrobial Peptides from Amphibian Anurans

García,

Fuentes,

Alonso

et al. 2024

J. Nat. Prod.

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“…However, multiple animal studies have demonstrated that host associated microbial symbionts indeed mediate signals synthesis. 4 , 5 , 6 , 7 A variety of chemical components are associated with potential pheromones, including volatile fatty acids, hydrocarbons, peptides, phenols, ketones, and others. These studies strongly support the fermentative hypothesis and underscore the irreplaceable role of microbes.…”

Section: Introductionmentioning

confidence: 99%

Characterizing the metabolome and microbiome at giant panda scent marking sites during the mating season

Hou,

Hull,

Fujimoto

et al. 2024

iScience

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Environmental factors and host sex influence the skin microbiota structure of Hong Kong newt (Paramesotriton hongkongensis) in a coldspot of chytridiomycosis in subtropical East Asia

WAN,

CHEN,

POON

et al. 2024

Integr. Zool.

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Chytridiomycosis, an infectious skin disease caused by the chytrid fungi, Batrachochytrium dendrobatidis and B. salamandrivorans, poses a significant threat to amphibian biodiversity worldwide. Antifungal bacteria found on the skin of chytrid‐resistant amphibians could potentially provide defense against chytridiomycosis and lower mortality rates among resistant individuals. The Hong Kong newt (Paramesotriton hongkongensis) is native to East Asia, a region suspected to be the origin of chytrids, and has exhibited asymptomatic infection, suggesting a long‐term coexistence with the chytrids. Therefore, the skin microbiota of this resistant species warrant investigation, along with other factors that can affect the microbiota. Among the 149 newts sampled in their natural habitats in Hong Kong, China, putative antifungal bacteria were found in all individuals. There were 314 amplicon sequence variants distributed over 25 genera of putative antifungal bacteria; abundant ones included Acinetobacter, Flavobacterium, and Novosphingobium spp. The skin microbiota compositions were strongly influenced by the inter‐site geographical distances. Despite inter‐site differences, we identified some core skin microbes across sites that could be vital to P. hongkongensis. The dominant cores included the family Comamonadaceae, family Chitinophagaceae, and class Betaproteobacteria. Moreover, habitat elevation and host sex also exhibited significant effects on skin microbiota compositions. The antifungal bacteria found on these newts offer an important resource for conservation against chytridiomycosis, such as developing probiotic treatments for susceptible species.

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Host macrocyclic acylcarnitines mediate symbiotic interactions between frogs and their skin microbiome

Cited by 3 publications

References 64 publications

A Comprehensive Review of Patented Antimicrobial Peptides from Amphibian Anurans

A Comprehensive Review of Patented Antimicrobial Peptides from Amphibian Anurans

Characterizing the metabolome and microbiome at giant panda scent marking sites during the mating season

Environmental factors and host sex influence the skin microbiota structure of Hong Kong newt (Paramesotriton hongkongensis) in a coldspot of chytridiomycosis in subtropical East Asia

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