Host/Guest Simulation of Fluorescent Probes Adsorbed into Low-Density Polyethylene, 1. Excimer Formation of 1,3-Di(1-pyrenyl)propane

Pozuelo, Javier; Atvars, Teresa Dib Zambon; Bravo, Julio; Baselga, Juan

doi:10.1002/1521-3919(20011101)10:9<808::aid-mats808>3.0.co;2-i

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…According to the excellent stability of SPIO-loading micelles, effect of SPIO improved DLE on drug loading and release. Further study, DPP is exposed in viscous or glassy environment, excimer form of DPP signi cantly decreases, resulting in a lower value of I e /I m [27].…”

Section: Discussionmentioning

confidence: 94%

Enhanced Thermodynamic, Pharmacokinetic and Theranostic Properties of Polymeric Micelles via Hydrophobic Core-clustering of Superparamagnetic Iron Oxide Nanoparticles

Jiang

Lee

Park

et al. 2021

Preprint

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Background: Superparamagnetic iron oxide nanoparticles (SPIO) have been applied for decades to design theranostic polymeric micelles for targeted cancer therapy and diagnostic MR imaging. However, the effects of SPIO on the physicochemical, and biological properties of polymeric micelles have not yet been fully elucidated. Therefore, we investigated potential effect of SPIO on the physical and biological properties of theranostic polymeric micelles using representative cancer drug (doxorubicin; Doxo) and polymer carrier (i.e., poly (ethylene glycol)-co-poly(D,L-lactide), PEG-PLA).Methods: SPIO were synthesized from Fe(acetyl acetonate)3 in an aryl ether. SPIO and Doxo were loaded into the polymeric micelles by a solvent-evaporation method. We observed the effect of SPIO-clustering on drug loading, micelle size, thermodynamic stability, and theranostic property of PEG-PLA polymeric micelles. In addition, cellular uptake behaviors, pharmacokinetic and biodistribution study were performed.Results: SPIO formed hydrophobic geometric cavity in the micelle core and significantly affected the integrity of micelles in terms of micelle size, Doxo loading, critical micelle concentration (CMC) and in vitro dissociation. In vivo pharmacokinetic studies also showed the enhanced Area Under Curve (AUC) and elongated the half-life of Doxo.Conclusions: Clustered SPIO in micelles largely affects not only MR imaging properties but also biological and physical properties of polymeric micelles.

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Section: Discussionmentioning

confidence: 94%

Enhanced Thermodynamic, Pharmacokinetic and Theranostic Properties of Polymeric Micelles via Hydrophobic Core-clustering of Superparamagnetic Iron Oxide Nanoparticles

Jiang

Lee

Park

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…According to the excellent stability of SPIO-loading micelles, effect of SPIO improved DLE on drug loading and release. Further study, DPP is exposed in viscous or glassy environment, excimer form of DPP significantly decreases, resulting in a lower value of I e /I m [26]. We consider this reflects the glass transition temperature (T g ) of the PLA micelle core in aqueous solution.…”

Section: Discussionmentioning

confidence: 99%

Enhanced thermodynamic, pharmacokinetic and theranostic properties of polymeric micelles via hydrophobic core-clustering of superparamagnetic iron oxide nanoparticles

et al. 2022

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Background Superparamagnetic iron oxide nanoparticles (SPIO) have been applied for decades to design theranostic polymeric micelles for targeted cancer therapy and diagnostic MR imaging. However, the effects of SPIO on the physicochemical, and biological properties of polymeric micelles have not yet been fully elucidated. Therefore, we investigated potential effect of SPIO on the physical and biological properties of theranostic polymeric micelles using representative cancer drug (doxorubicin; Doxo) and polymer carrier (i.e., poly (ethylene glycol)-co-poly(D,L-lactide), PEG-PLA). Methods SPIO were synthesized from Fe(acetyl acetonate)3 in an aryl ether. SPIO and Doxo were loaded into the polymeric micelles by a solvent-evaporation method. We observed the effect of SPIO-clustering on drug loading, micelle size, thermodynamic stability, and theranostic property of PEG-PLA polymeric micelles. In addition, cellular uptake behaviors, pharmacokinetic and biodistribution study were performed. Results SPIO formed hydrophobic geometric cavity in the micelle core and significantly affected the integrity of micelles in terms of micelle size, Doxo loading, critical micelle concentration (CMC) and in vitro dissociation. In vivo pharmacokinetic studies also showed the enhanced Area Under Curve (AUC) and elongated the half-life of Doxo. Conclusions Clustered SPIO in micelles largely affects not only MR imaging properties but also biological and physical properties of polymeric micelles.

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Dependence of relaxation processes in a low-density polyethylene with different crosslink densities investigated by fluorescence spectroscopy

Martins¹,

Gulmine²,

Akcelrud³

et al. 2006

Polymer

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Host/Guest Simulation of Fluorescent Probes Adsorbed into Low-Density Polyethylene, 1. Excimer Formation of 1,3-Di(1-pyrenyl)propane

Cited by 4 publications

References 17 publications

Enhanced Thermodynamic, Pharmacokinetic and Theranostic Properties of Polymeric Micelles via Hydrophobic Core-clustering of Superparamagnetic Iron Oxide Nanoparticles

Enhanced Thermodynamic, Pharmacokinetic and Theranostic Properties of Polymeric Micelles via Hydrophobic Core-clustering of Superparamagnetic Iron Oxide Nanoparticles

Enhanced thermodynamic, pharmacokinetic and theranostic properties of polymeric micelles via hydrophobic core-clustering of superparamagnetic iron oxide nanoparticles

Dependence of relaxation processes in a low-density polyethylene with different crosslink densities investigated by fluorescence spectroscopy

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