Host-Guest Interaction between Herbicide Oxadiargyl and Hydroxypropyl-β-Cyclodextrin

Abstract

In the face of a growing human population and increased urbanization, the demand for pesticides will simply rise. Farmers must escalate yields on increasingly fewer farm acres. However, the risks of pesticides, whether real or perceived, may force changes in the way these chemicals are used. Scientists are working toward pest control plans that are environmentally sound, effective, and profitable. In this context the development of new pesticide formulations which may improve application effectiveness, safety, handling, and storage can be pointed out as a solution. As a contribution to the area, the microencapsulation of the herbicide oxadiargyl (OXA) in (2-hydroxypropyl)-β-cyclodextrin (HP-β-CD) was performed. The study was conducted in different aqueous media (ultrapure water and in different pH buffer solutions). In all cases an increment of the oxadiargyl solubility as a function of the HP-β-CD concentration that has been related to the formation of an inclusion complex was verified. UV-Vis and NMR experiments allowed concluding that the stoichiometry of the OXA/HP-β-CD complex formed is 1 : 1. The gathered results can be regarded as an important step for its removal from industrial effluents and/or to increase the stabilizing action, encapsulation, and adsorption in water treatment plants.

Analytical and in silico study of the inclusion complexes between tropane alkaloids atropine and scopolamine with cyclodextrins

“…Hydroxypropyl-β-cyclodextrin (HPβCD) is widely used as a solubilizing agent and carrier with rapid dissolution for much poorly water-soluble ACs (Perchyonok et al 2014). Several inclusion complexes with CDs have been reported in the promising field of environmental friendly pesticides (Benfeito et al 2013;Gao et al 2019b;Geng et al 2018;Kim et al 2019;Villaverde 2007;Villaverde et al 2004Villaverde et al , 2005Yanez et al 2012).…”

Molecular Encapsulation of Herbicide Terbuthylazine in Native and Modifiedβ-Cyclodextrin

“…Among the advantages of cyclodextrin complexes of pesticides are enhanced stabilization, increased solubility and bioavailability, and controlled release properties [12][13][14][15][16][17][18]. Continuing our investigation on the complexation of pesticides with cyclodextrins [15][16][17][18], herein we report the preparation and characterization of some water-soluble inclusion complexes formed by the herbicide terbuthylazine and -cyclodextrin ( -CD). Furthermore, another modified cyclodextrin, 2-hydroxypropyl--cyclodextrin (HP--CD), was used in a comparative way to ascertain the interested in exploring the solubilization effect of CDs on terbuthylazine and the binding ability of the resulting inclusion complexes, which would provide a useful approach for obtaining novel terbuthylazine-based formulations with increased water solubility, high bioavailability, and low toxicity.…”

Stability and spatial arrangement of the 2,4-dichlorophenoxyacetic acid and β-cyclodextrin inclusion compound: A theoretical study

“…However, the existence of these compounds in the environment and ecosystems causes adverse impacts by contaminating soil, surface and groundwater, thus contributing to a loss in biodiversity [5]. In this sense, CDs can be employed in remediation [5][6][7][8][9] or in the formulation of new herbicides [10,11].…”