Host-Guest Chemistry in Supramolecular Theranostics

Yu, Guocan; Chen, Xiaoyuan

doi:10.7150/thno.31653

Cited by 158 publications

(124 citation statements)

References 257 publications

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“…Inclusion of the toluene molecule does not affect the crystal parameters of ε-phase, and the framework arrangement, identical to that observed in experiments using DCM, is maintained (see Table 1). Guest molecules mainly interact with the host frameworks through noncovalent binding [28]. Intermolecular interactions of toluene and γ-CD molecules in ε•tol-phase were quantified using Hirshfeld surface analysis.…”

Section: Crystal Structure Analysis Of the New Phases Of γ-Cd-mof-1mentioning

confidence: 99%

Stability and Phase Transitions of Nontoxic γ-Cyclodextrin-K+ Metal-Organic Framework in Various Solvents

et al. 2020

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Cyclodextrin (CD) has been used to prepare biocompatible and nontoxic metal-organic frameworks (MOFs) suitable for biomedical applications as drug carriers. In this study, γ-CD/K-based MOF (γ-CD-MOF-1-α) was synthesized and its stability in various solvents was explored by single-crystal X-ray diffractometry (SCXRD) and powder X-ray diffractometry (PXRD). As a result of solvent-induced phase transformations, two novel crystalline phases of γ-CD-MOF-1 were discovered. The newly formed ε- and δ-phases crystallize in orthorhombic and tetragonal symmetry, respectively. In ε-phase, toluene was determined as a guest molecule by SCXRD. Interactions between γ-cyclodextrin and solvent molecules in ε-phase were evaluated using Hirshfeld surface analysis. The thermal stability of the new crystal forms of γ-CD-MOF-1 was analyzed by differential scanning calorimetry and thermogravimetric analysis.

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Section: Crystal Structure Analysis Of the New Phases Of γ-Cd-mof-1mentioning

confidence: 99%

Stability and Phase Transitions of Nontoxic γ-Cyclodextrin-K+ Metal-Organic Framework in Various Solvents

et al. 2020

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“…The host generally has a cavity-like space or a suitable space to hold another molecule, which is then called the guest. Such systems are also recognised in biology [3], where they are denoted as enzyme-receptor systems and/or lock-key system. Protein folding processes involve excellent examples of host-guest systems in biology [4].…”

Section: Introductionmentioning

confidence: 99%

“…Currently, a main driving force for the interest in host-guest systems is their potential role in cutting-edge advances in fields such Ogoshi et al in 2008 [19]. The progress in host-guest chemistry of pillar [n]arenes is well documented in a recent review by Guo et al [3].…”

Section: Introductionmentioning

confidence: 99%

Two-photon absorption in host-guest complexes

Alam

Ruud

2020

Molecular Physics

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We present an extensive analysis of one-and two-photon absorption processes in some organic hostguest (H-G) complexes using linear and quadratic response theory within the framework of timedependent density functional theory. For this purpose, we have considered all possible 20 host-guest complexes constructed from 4 host and 5 guest molecules. We have analysed how the one-and two-photon activity of the host and guest molecules are transferred to the respective host-guest complexes and how the electron donating and electron accepting ability of host-guest complexes affect their two-photon activity. Based on an analysis using the concept of channel interference, we have performed an in-depth analysis of the two-photon absorption processes in all these systems and provided a microscopic explanation for their variation among different complexes.

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“…During the past decades, numerous supramolecular host molecules have been developed as artificial receptors, and their host-guest interactions as well as their derived supramolecular materials have shown significant potentials in biomedical applications 25-31. Based on host-guest interactions, supramolecular host molecules may influence the physiochemical and biological properties of guest species, such as solubility, stability, toxicity and therapeutic efficacy 32-35. As one of the most prominent example in this area, Sugammadex, a γ-cyclodextrin derivative, has been approved by more than 50 countries, including the European countries and the U.S.A., as a specific reversal agent for some of the non-depolarizing steroidal NMBAs including rocuronium and vecuronium 36, 37.…”

Section: Introductionmentioning

confidence: 99%

Supramolecular therapeutics to treat the side effects induced by a depolarizing neuromuscular blocking agent

Zhang

Qian

et al. 2019

Theranostics

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Succinylcholine (Sch) is the only depolarizing neuromuscular blocking agent widely used for rapid sequence induction in emergency rooms. Unfortunately, a variety of (sometimes lethal) adverse effects, such as hyperkalemia and cardiac arrest, are associated with its use, and currently there are no specific antidotes to reverse Sch or to treat these side-effects. Methods: The binding behaviors of Sch and several synthetic receptors, including cucurbit[7]uril, sulfo-calix[4]arene and water-soluble carboxylatopillar[6]arene (WP[6]), were first investigated. With a mouse model, a leathal dose of Sch was selected for evaluation of the antidotal effects of these synthetic receptors on Sch induced mortality. The antidotal effects of a selected synthetic receptor, WP[6], on Sch induced cardiac arrhythmias, hyperkalemia, rhabdomyolysis and paralysis were subsequently evaluated with rat and mouse models. The reversal mechanism was also investigated at a cellular level. Results: All of these macrocyclic molecules exhibited relatively high binding affinities with Sch in vitro . In a Sch-overdosed mouse model, immediate injection of these synthetic receptors right after Sch administration increased the overall survival rate, with WP[6] standing out with the most effective antidotal effects. In addition, administration of WP[6] also reversed the paralysis induced by Sch in a mouse model. Moreover, infusion of WP[6] to Sch-overdosed rats reduced the incidence of cardiac arrhythmia, inhibited the otherwise abnormally high serum potassium levels, and relieved the muscular damage. At the cellular level, WP[6] reversed the Sch induced depolarization and reduced the efflux of intracellular potassium. Conclusion: Synthetic receptors, particularly WP[6], exhibited high binding affinities towards Sch, and presented a significant potential as supramolecular therapeutics to treat the various side effects of Sch by specifically sequestering Sch in vivo .

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Host-Guest Chemistry in Supramolecular Theranostics

Cited by 158 publications

References 257 publications

Stability and Phase Transitions of Nontoxic γ-Cyclodextrin-K+ Metal-Organic Framework in Various Solvents

Stability and Phase Transitions of Nontoxic γ-Cyclodextrin-K+ Metal-Organic Framework in Various Solvents

Two-photon absorption in host-guest complexes

Supramolecular therapeutics to treat the side effects induced by a depolarizing neuromuscular blocking agent

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